EDITORIAL Is heart failure a metabolic disease? René Lerch
	BASIC ARTICLE Myocardial energy metabolism in heart failure: unanswered questions and therapeutic opportunities William C. Stanley
	MAIN CLINICAL ARTICLE Prevalence, increase and costs of heart failure Paul Mohacsi, Giorgio Moschovitis, Hildegard Tanner, Otto M. Hess
	METABOLIC IMAGING Metabolic imaging of heart failure F.C. Visser
	FOCUS ON VASTAREL Latest trends in the treatment of ischemic heart failure: new perspectives using a metabolic approach P. Meurin
	CASE REPORT Tachyarrhythmia induced cardiomyopathy P.T. Trindade, R. Lerch
	FEATURED RESEARCH Role of AMP-activated protein kinase in mechanism of metformin action
	REFRESHER CORNER Left ventricular pressure-volume relations and myocardial dysfunction in pressure or volume overload Walter J. Paulus
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The transthoracic echocardiogram in the parasternal long-axis view depicts moderate mitral regurgitation (panel A) during atrial fibrillation, which disappears after cardioversion to sinus rhythm (panel B).