Heart failure in patients with diabetes

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ISSN 1566-0338


Diabetes and heart failure – a challenging combination


Derek J. Hausenloy , MBChB, PhD, FACC, FESC
Hatter Cardiovascular Institute, University College London, London, UK; Cardiovascular & Metabolic Disorders Duke-NUS Medical School, Singapore

  • Diabetes mellitus and heart failure (HF) often coexist, and together, their effects on clinical outcomes are compounded. On the one hand, diabetes is an independent risk factor for developing heart failure, with a twofold increased risk in men, and a fivefold increased risk in women. On the other hand, in patients with heart failure, diabetes mellitus is highly prevalent, being present in 25% of chronic heart failure cases, and 40% of acute heart failure cases. The latter is especially so in heart failure with preserved ejection fraction. Individually, heart failure has a poorer prognosis than diabetes mellitus, and should therefore be the priority in terms of treatment. In this issue of Heart & Metabolism, the intimate relationship between diabetes and heart failure is explored, with a special focus on their changing epidemiology, the mechanisms underlying diabetes with concomitant heart failure, the effect of antidiabetic drugs on heart failure risk and other cardiovascular outcomes, and the diagnosis and management of patients with diabetes and HF.
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