EDITORIAL Obesity and heart disease Gary D. Lopaschuk BASIC ARTICLE Free fatty acid oxidation in insulin resistance and obesity E. Dale Abel MAIN CLINICAL ARTICLE Obesity and mortality: summary of best evidence with explanations for the obesity paradox Jennifer Logue, [...]

EDITORIAL The cardiac cell: its survival and performance Mario Marzilli Evolution of the metabolic approach to heart disease Vaninder K. Sidhu, Gary D. Lopaschuk Cardiac metabolism in the diabetic patient Danielle Feuvray Cardiomyopathies and heart failure Lionel H. Opie The [...]

EDITORIAL Diabetes and cardiovascular disease Gary D. Lopaschuk BASIC ARTICLE Non ischemic heart failure in diabetes mellitus: still incompletely understood Romain Harmancey, Heinrich Taegtmeyer MAIN CLINICAL ARTICLE Clinical manifestations of diabetic cardiomyopathy Sihem Boudina METABOLIC IMAGING Nuclear magnetic resonance for [...]

EDITORIAL Circadian rhythms and cardiovascular disease Danielle Feuvray BASIC ARTICLE Diurnal variations in myocardial metabolism Ju-Yun Tsai, Martin E. Young MAIN CLINICAL ARTICLE Disruption of normal circadian rhythms and cardiovascular events Alberto Dominguez-Rodrigueza, Pedro Abreu-Gonzalezb, Juan Carlos Kaskic METABOLIC IMAGING [...]

EDITORIAL Chronic ischemic heart disease Mario Marzilli BASIC ARTICLE Genomics, transcriptomics, and proteomics of the ischemic heart Marcus C. Schauba, Eliana Lucchinettib, Michael Zauggb MAIN CLINICAL ARTICLE Identifying patients at risk of progressive left ventricular dysfunction Florence Pinet METABOLIC IMAGING [...]

EDITORIAL Measuring cardiac efficiency: is it clinically useful? Frans Visser BASIC ARTICLE Molecular basis of cardiac efficiency Heiko Bugger, E. Dale Abel MAIN CLINICAL ARTICLE Assessment and clinical applications of myocardial efficiency Olakunle Akinboboye METABOLIC IMAGING Myocardial efficiency in heart [...]

EDITORIAL Stable angina – taking time Graham Jackson BASIC ARTICLE Optimizing cardiac energy substrate metabolism: a novel therapeutic intervention for ischemic heart disease Jagdip S. Jaswal, Virgilio J.J. Cadete, Gary D. Lopaschuk MAIN CLINICAL ARTICLE Stable angina: a balanced approach [...]

EDITORIAL Cardiac toxicity Danielle Feuvray BASIC ARTICLE Molecular basis of anthracycline-induced cardiotoxicity Richard S. Vander Heide and Thomas J. L’Ecuyer Anthracycline, cardiotoxicity, cardiac muscle, oxidative stress, apoptosis, mechanism MAIN CLINICAL ARTICLE Mechanisms, manifestations, and management of digoxin toxicity Lionel G. [...]

EDITORIAL Arrhythmia and metabolism Danielle Feuvray BASIC ARTICLE Metabolic signals of arrhythmia Jason R.B.Dyck and Peter E. Light Arrhythmia, cardiac energy metabolism, ion channels, AMPK, PRKAG2 MAIN CLINICAL ARTICLE Metabolic gene defects and risk of arrhythmia Patrick T. Ellinor, David [...]