• Read the whole issue
• EDITORIAL
  Hypertension: what’s up?
  Michael Marber
  Read the editorial
   
  ORIGINAL ARTICLES
  Blood pressure classification and values to treat
  Giuseppe Mancia
  
  Keywords: antihypertensive drug; blood pressure; cardiovascular risk; hypertension
  
  
  
  
   
  Diagnosing hypertension
  Richard Hobbs
  
  Keywords: ABPM; blood pressure threshold; diagnosis; HBP; hypertension
  
  
  
  
   
  The 2018 European guidelines: tailoring treatment to new hypertension goals
  Krzysztof Narkiewicz
  
  Keywords: guideline; hypertension; treatment
  
  
  
  
   
  Tailoring treatment to comorbidities
  Claudio Borghi; Crescenzio Bentivenga; Eugenio Cosentino; Matteo Landolfo
  
  Keywords: ACE inhibitor; hypertension; lipid; risk factor
  
  
  
  
   
  Global interventions in hypertension
  Charalambos Vlachopoulos; Dimitrios Terentes Printzios
  
  Keywords: arterial stiffness; global; hypertension; intervention; organ damage; vascular aging
  
  
  
  
  CASE REPORT
  Primary hyperaldosteronism—seek and you may find
  Albert Ferro; Elizabeth Adeyeye
  
  Keywords: metomidate; PET-CT; primary hyperaldosteronism
  
  
  
  
  REFRESHER CORNER
  Doctors and patients: improving partnership, treatment, and outcomes in hypertension
  Chris Arden
  
  Keywords: adherence; hypertension; persistence
  
  
  
  
  HOT TOPICS
  Will the polypill be the solution?
  Michael Marber
  
  Keywords: cardiovascular risk; polypill
  
  
  
  
  GLOSSARY
  G. D. Lopaschuk

• EDITORIAL
  Stable angina: to stent or not to sent ?
  Luis Henrique Wolff Gowdak
  Read the editorial
   
  ORIGINAL ARTICLES
  ORBITA and ISCHEMIA: what’s the message?
  William E. Boden
  
  Keywords: ISCHEMIA; ORBITA; percutaneous coronary intervention; stable ischemic heart disease
  
  
  
  
   
  Fractional flow reserve: current evidence base in stable coronary artery disease
  Ozan M. Demir; Matt Ryan; Haseeb Rahman; Divaka Perera
  
  Keywords: coronary physiology; fractional flow reserve; percutaneous coronary intervention
  
  
  
  
   
  Post-PCI angina: should I worry?
  Luis Henrique Wolff Gowdak; Mario Marzilli
  
  Keywords: angina; myocardial ischemia; percutaneous coronary intervention; prognosis
  
  
  
  
   
  What is optimal medical therapy?
  Mario Marzilli; Maria Chiara Scali
  
  Keywords: guideline dictated medical therapy (GDMT); optimal medical therapy (OMT); trimetazidine
  
  
  
  
   
  Trimetazidine in the era of PCI
  Olímpio R. França Neto
  
  Keywords: ischemic heart disease; metabolic protection; percutaneous coronary intervention; trimetazidine
  
  
  
  
  CASE REPORT
  A patient with stable angina and mild ischemia: do I have the COURAGE not to stent the lesion?
  Luis Henrique Wolff Gowdak
  
  Keywords: angina; treatment; coronary artery disease; trimetazidine; myocardial revascularization; angioplasty
  
  
  
  
  REFRESHER CORNER
  Composite end points in cardiovascular clinical trials
  Otavio Berwanger, M. Julia Machline-Carrion
  
  Keywords: cardiovascular clinical trial; composite end point; critical appraisal
  
  
  
  
  HOT TOPICS
  Choosing between functional and anatomical imaging for stable angina
  Aida Soufiani
  
  diagnostic strategy; stable angina; coronary artery disease; functional testing; anatomical imaging;
  guideline; prognosis
  
  
  diagnostic strategy; stable angina; coronary artery disease; functional testing; anatomical imaging;
  guideline; prognosis
  
  GLOSSARY
  G. D. Lopaschuk

• EDITORIAL
  The complexity of heart failure
  G. D. Lopaschuk
  Read the editorial
   
  ORIGINAL ARTICLES
  The interplay between peripheral organs and the heart in heart failure
  A. Bielecka-Dabrowa, B. Godoy, M. Banach, S. von Haehling
  
  Keywords: comorbidities; heart failure; peripheral organs
  
  
  
  
   
  Cardio-oncology: preventing cardiac damage from mandatory cancer therapy?
  O. J. Müller, L. Lehmann
  
  Keywords: cardio-oncology; heart failure
  
  
  
  
   
  New kids on the block to treat heart failure
  E. Bertero, C. Maack
  
  Keywords: mitochondria-targeted drug; myosin activator; soluble guanylate cyclase activator
  
  
  
  
   
  A metabolism-based, right ventricle-specific mechanism of heart failure
  G. Sutendra, E. D. Michelakis
  
  Keywords: Mef2c; miR208; pulmonary hypertension; right ventricle
  
  
  
  
   
  Heart failure: a metabolic issue?
  M. Marzilli
  
  Keywords: heart failure; New York Heart Association; trimetazidine
  
  
  
  
  CASE REPORT
  Exercise training in chronic heart failure? A case report
  M. F. Piepoli
  
  Keywords: exercise testing; heart failure; prognosis
  
  
  
  
  REFRESHER CORNER
  What fuels the failing heart?
  G. D. Lopaschuk
  
  Keywords: fatty acid oxidation; glycolysis; glucose oxidation; ketone oxidation
  
  
  
  
  HOT TOPICS
  Super cool imaging of energy metabolism in the heart
  C. H. Cunningham
  
  Keywords: cardiomyocytes; dynamic nuclear polarization; heart failure; MRI
  
  
  
  
  GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Acute coronary syndromes: changing face
  M. Marzilli
  Read the editorial
• ORIGINAL ARTICLES
  The changing face of acute coronary syndromes
  S. Al Yaseen, A. Al Badri, J. Wei, C.Shufelt, N. Bairey Merz
  
  Keywords: acute coronary syndrome; non–ST-segment elevation myocardial infarction; stable ischemic heart disease; sex differences; ST-segment elevation myocardial infarction
  
  
  
• ORIGINAL ARTICLES
  Acute coronary syndrome without coronary obstructions: diagnosis and treatment
  G. Niccoli, G. Scalone, F. Crea
  
  Keywords: acute myocardial infarction; microcirculation; no obstructive coronary atherosclerosis
  
  
  
• ORIGINAL ARTICLES
  Does unstable angina still exist?
  C. A. Rambarat, I. Y. Elgendy, C. J. Pepine
  
  Keywords: myocardial infarction; troponin; unstable angina
  
  
  
• ORIGINAL ARTICLES
  Acute coronary syndrome: the illusion of treatment!
  M. Marzilli
  
  Keywords: acute coronary syndrome; percutaneous coronary intervention; therapeutic illusion
  
  
  
• ORIGINAL ARTICLES
  Focus on trimetazidine in acute coronary syndrome
  L. H. W. Gowdak
  
  Keywords: arrhythmia; myocardial infarction; prognosis; treatment; trimetazidine
  
  
  
• CASE REPORT
  From atropine eye drops to takotsubo syndrome in an 89-year-old lady
  M. C. Scali, M. Marzilli
  
  Keywords: acute microvascular dysfunction; atropine; takotsubo syndrome
  
  
  
• REFRESHER CORNER
  Cardiac energy metabolism in mild and severe ischemia
  G. D. Lopaschuk
  
  Keywords: fatty acid oxidation; glucose oxidation; glycolysis
  
  
  
• HOT TOPICS
  False positive troponins
  M. Marber
  
  Keywords: acute coronary syndrome; biomarker; necrosis; troponin
  
  
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Heart failure in real life
  M. Marber
  Read the editorial
• ORIGINAL ARTICLES
  Assessing the breathless patient
  M. R. Cowie
  
  Keywords: diagnosis, heart failure; natriuretic peptide
  
• ORIGINAL ARTICLES
  Heart failure with mid-range EF (HFmrEF): a mildly reduced EF does not imply a mild
  disease
  C. Tschöpe, B. Pieske
  
  Keywords: diagnostic, HFmrEF, pathophysiology, treatment
  
• ORIGINAL ARTICLES
  Renal function in acute heart failure: what can go wrong and what we can do about it
  S. R. Goldsmith
  
  Keywords: acute heart failure, kidney, afterload/preload
  
• ORIGINAL ARTICLES
  Preventing heart failure hospital readmissions: challenges and opportunities
  B. Ziaeian, G. C. Fonarow
  
  Keywords: heart failure, prevention, process measures, quality of care, readmission
  
• ORIGINAL ARTICLES
  Clinical benefits of trimetazidine in heart failure
  G. M. C. Rosano
  
  Keywords: cardiac energy metabolism, heart failure, trimetazidine
  
• CASE REPORT
  Team-based management to improve real-world outcomes in heart failure
  M. Ryan
  
  Keywords: Team-based management in heart failure
  
• REFRESHER CORNER
  Cellular metabolic and structural changes in heart failure
  G. D. Lopaschuk
  
  Keywords: apoptosis, autophagy, excitation-contraction coupling, mitochondria, mitofission, mitofusion,mitophagy
  
• HOT TOPICS
  Identifying heart failure in the emergency room
  M. C. Scali
  
  Keywords: B-line, emergency room, heart failure, lung comet
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Diabetes: getting to the heart of the matter.
  G. D. Lopaschuk
  Read the editorial
• ORIGINAL ARTICLES
  Diabetes: the cost of globalization
  P. M. Nilsson, L. Bennet
  
  Keywords: costs, diabetes, global, lifestyle, migration, obesity
  
• ORIGINAL ARTICLES
  Better glycemic control and cardiovascular outcomes
  G. D. Lopaschuk
  
  Keywords: antihyperglycemic agent, cardiovascular outcome, heart failure, type 2 diabetes mellitus
  
• ORIGINAL ARTICLES
  Treating myocardial ischemia in diabetics: drugs, surgery, and stents
  R. Belardinelli
  
  Keywords: chronic angina, diabetes mellitus, therapeutic strategy
  
• ORIGINAL ARTICLES
  Early detection of left ventricular dysfunction in diabetes
  D. Y. Leung, M. Leung
  
  Keywords: cardiomyopathy, diabetes, echocardiography
  
• ORIGINAL ARTICLES
  Clinical benefits of targeting cardiac cells directly with trimetazidine in patients with coronary disease and diabetes
  G. Fragasso, G. Anastasia, G. Monaca, G. Pinto
  
  Keywords: CAD, diabetes, myocardial metabolism, trimetazidine
  
• CASE REPORT
  Managing chest pain in a diabetic patient
  M. C. Scali
  
  Keywords: B-lines, risk, stress-echo
  
• REFRESHER CORNER
  Cardiac energy metabolism in diabetes
  K. L. Ho, J. R. Ussher
  
  Keywords: energy metabolism, fatty acid oxidation, glucose oxidation, type 1 diabetes, type 2 diabetes
  
• HOT TOPICS
  Cardiovascular diseases and diabetes: causes and cures
  J. E. Salles
  
  Keywords:  
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Living with pain
  L. H. W. Gowdak
  Read the editorial
• ORIGINAL ARTICLES
  Refractory angina or inappropriate antianginal therapy?
  A. Huqi, M. Marzilli
  
  Keywords: CAD, guideline-directed medical therapy, persistent angina
  
• ORIGINAL ARTICLES
  Prevalence of refractory angina in clinical practice
  L. H. W. Gowdak
  
  Keywords: optimal medical therapy, prevalence, refractory angina
  
• ORIGINAL ARTICLES
  Prognostic implications of refractory angina
  P. G. Steg
  
  Keywords: angina, ischemia, prognosis
  
• ORIGINAL ARTICLES
  Nonpharmacological approaches to refractory angina.
  R. Cheng, T. D. Henry
  
  Keywords: enhanced external counterpulsation, neuromodulation, PCI, refractory angina
  
• ORIGINAL ARTICLES
  Clinical benefits of treating angina directly at the cardiac cell level with
  trimetazidine.
  I. Milinković, A. J. Coats, G. Rosano, Y. Lopatin, P. M. Seferović
  
  Keywords: antianginal, cardiomyocyte, trimetazidine
  
• CASE REPORT
  The role of optimal medical therapy in patients with refractory angina
  L. H. W. Gowdak
  
  Keywords: angina, coronary artery disease, treatment
  
• REFRESHER CORNER
  Estimating ischemic burden
  V. Agarwal, M. F. Di Carli
  
  Keywords: coronary flow reserve (CFR), ischemic burden, multimodality cardiac imaging
  
• HOT TOPICS
  Errare humanum est, perseverare autem diabolicum
  A. Huqi
  
  Keywords: comparative effectiveness of noninvasive diagnostic strategies, coronary artery disease, ischemic heart disease, percutaneous coronary intervention
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  HFpEF, is it more than just the sum of its parts?
  M. Marber
  Read the editorial
• ORIGINAL ARTICLES
  Heart failure with preserved ejection fraction (HFpEF): a basic and clinical perspective.
  A. Shah, P. C. Chowienczyk
  
  Keywords: diastolic dysfunction, HFpEF, ventricular-vascular coupling
  
• ORIGINAL ARTICLES
  How to diagnose heart failure with preserved ejection fraction.
  T. H. Marwick
  
  Keywords: diagnosis, diastolic dysfunction, heart failure with preserved ejection fraction
  
• ORIGINAL ARTICLES
  Treatment of HFpEF: why we have no evidence.
  M. Marber
  
  Keywords: HFpEF, left ventricular ejection fraction
  
• ORIGINAL ARTICLES
  Imaging fibrosis in heart failure with preserved ejection fraction.
  A. N. Bhuva, R. Schofield, R. T. Lumbers, C. H. Manisty, J. C. Moon
  
  Keywords: HFpEF, myocardial fibrosis, T1 mapping
  
• ORIGINAL ARTICLES
  Trimetazidine in the new 2016 European guidelines on heart failure and beyond.
  Y. Lopatin
  
  Keywords: heart failure, guidelines, myocardial metabolism, trimetazidine
  
• CASE REPORT
  HFpEF or just multiple comorbidities? The challenges of making a definitive diagnosis.
  J. Webb
  
  Keywords: cardiac magnetic resonance imaging, HFpEF, pressure-volume loop analysis
  
• REFRESHER CORNER
  Heart failure with preserved ejection fraction–where is the problem: heart or arteries?
  S. Ewen, M. Böhm
  
  Keywords: chronic heart failure, ESC guidelines, heart failure with preserved ejection fraction
  
• HOT TOPICS
  The failing heart: an engine operating on “bad” fuel.
  V. Sequeira, J. van der Velden
  
  Keywords: ADP elevation, cardiac contractility and energetics, cardiomyocyte contractile reserve, diastolic dysfunction
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Burning fat to increase metabolic rates size: myth or reality
  Derek J. Hausenloy, MD, PhD, FACC, FESC
  Read the editorial
• ORIGINAL ARTICLES
  Reperfusion – the good, the bad, and the ugly
  Gerd Heusch, FACC, FESC, FRCP
  Institute for Pathophysiology, West German Heart and Vascular Center,
  University of Essen Medical School, Essen, Germany
  
  Keywords: cardioprotection, myocardial ischemia, reperfusion
  
• ORIGINAL ARTICLES
  Mechanical interventions to reduce myocardial infarct size
  Michael Rahbek Schmidt, MD, PhD; Nichlas Riise Jespersen, MD; Hans Erik Bøtker, MD, PhD, DMSc
  Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
  
  Keywords: ischemic preconditioning, myocardial infarction, reperfusion injury
  
• ORIGINAL ARTICLES
  How to measure myocardial infarct size by cardiac magnetic resonance imaging
  David Corcoran, BMedSci MRCP; Colin Berry, PhD, FACC, FESC, FRCP
  BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow
  Golden Jubilee National Hospital, Clydebank, UK
  
  Keywords: acute myocardial infarction, CMR imaging, infarct size
  
• ORIGINAL ARTICLES
  Pharmacological agents for reducing myocardial infarct size in ST-segment elevation myocardial infarction
  Thomas Bochaton, MD; François Derimay, MD; Michel Ovize, MD, PhD
  Louis Pradel Hospital, Cardiovascular Functional Exploration Service,
  Clinical Investigation Center & UMR1060 (CarMeN), Claude Bernard University Lyon 1, Lyon, France
  
  Keywords: ischemia-reperfusion, ST-segment elevation myocardial infarction, treatment of reperfusion injury
  
• ORIGINAL ARTICLES
  The cardioprotective effects of trimetazidine
  Petr Widimsky, MD, DrSc, FESC, FACC
  Cardiocenter, Third Faculty of Medicine, Charles University Prague, Czech Republic
  
  Keywords: angina, cardioprotection; trimetazidine
  
• CASE REPORT
  Assessing myocardial salvage in reperfused STEMI patients by hybrid cardiac PET-MR imaging
  Heerajnarain Bulluck, MBBS, MRCP
  The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK;
  The National Institute of Health Research University College London Hospitals Biomedical Research Center, UK
  
  Keywords: myocardial salvage, PET-MR, ST-segment elevation myocardial infarction
  
• REFRESHER CORNER
  Metabolic changes in the acutely ischemic heart
  Gary D. Lopaschuk, PhD
  Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
  
  Keywords: glycolysis; ischemia, reperfusion
  glycolysis; ischemia, reperfusion
  
• HOT TOPICS
  Reducing myocardial infarct size by remote ischemic conditioning
  Luciano Candilio, MD(Res)
  The Hatter Cardiovascular Institute, University College London, London, UK
  
  Keywords: cardioprotection, myocardial infarction, remote ischemic conditioning
  
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Burning fat to increase metabolic rates
  G. D. Lopaschuk
  Read the editorial
• ORIGINAL ARTICLES
  Brown adipose tissue and the genetics of obesity
  Ande Satyanarayana, PhD
  Department of Biochemistry and Molecular Biology, Molecular Oncology & Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia, USA
  
  Keywords: beige cells, brown fat, genetic mouse models, oxidative metabolism, PGC1α, thermogenesis; UCP1
  
• ORIGINAL ARTICLES
  Integrated control of brown adipose tissue
  Emanuele Marzetti, MD, PhD1; Emanuela D’Angelo, MD1; Giulia Savera, BS1; Christiaan Leeuwenburgh, PhD2; Riccardo Calvani, PhD1
  1Department of Geriatrics, Neurosciences and Orthopedics, Teaching Hospital “Agostino Gemelli,” Rome, Italy 2Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, USA
  
  Keywords: adiposity, beige cells, diabetes mellitus, energy metabolism, inflammation, mitochondrial respiration, positron emission tomography (PET), sympathomimetics, weight loss
  
• ORIGINAL ARTICLES
  Assessing brown adipose tissue in humans
  Yu-Shin Ding, PhD New York University School of Medicine, Departments of Radiology and Psychiatry, New York, NY, USA
  
  Keywords: brown adipose tissue, [11C]MRB, obesity, norepinephrine transporter, positron emission tomography (PET), sympathetic nervous system
  
• ORIGINAL ARTICLES
  Brown adipose tissue as a potential therapeutic target in obesity therapy
  Niels Jessen, MD, PhD Research Laboratory for Biochemical Pathology, Department for Clinical Medicine, Aarhus University, Denmark
  
  Keywords: activators of thermogenesis, brown adipose tissue, obesity
  
• ORIGINAL ARTICLES
  Benefits of trimetazidine (TMZ) in obese patients
  Fausto J. Pinto, FESC, FACC Lisbon University Medical School, University of Lisbon, Lisbon, Portugal
  
  Keywords: ischemic heart disease, obesity; trimetazidine
  
• CASE REPORT
  Obesity and cardiovascular disease
  Giacinta Guarini, MD, PhD Cardiovascular Medicine Division, Cardio Thoracic and Vascular Department, University of Pisa, Italy
  
  Keywords: heart failure, obesity cardiomyopathy, obesity paradox
  
• REFRESHER CORNER
  Uncoupling proteins as mediators of mitochondrial metabolic rates
  Gary D. Lopaschuk, PhD Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
  
  Keywords: mitochondria, mitochondrial membrane potential, thermogenesis, uncoupling protein 1, uncoupling protein 3
  
• HOT TOPICS
  Will PCSK9 inhibitors stand up to statins till the end?
  Alda Huqi, MD, PhD
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Cardiovascular events in diabetics: a great challenge and an unsolved problem
  M. Marzilli
  Read the editorial
• ORIGINAL ARTICLES
  Diabetes and ischemia: similarities in cardiac energy metabolism
  Tariq R. Altamimi, BSc and Gary D. Lopaschuk, PhD Cardiovascular Translational Science Institute and Department of Pediatrics, University of Alberta, Edmonton, Canada
  
  Keywords: cardiac efficiency; diabetes; energy metabolism; heart; ischemia
  
• ORIGINAL ARTICLES
  Stents, surgery, and optimal medical therapy in diabetes
  Sonya N. Burgess, BSc, MBChB, FRACP; John K. French, BMedSc, MBChB, MSc, PhD Department of Cardiology, Liverpool Hospital and SWS Clinical School, The University of New South Wales, Sydney, NSW, Australia
  
  Keywords: coronary artery bypass graft surgery, coronary heart disease, diabetes mellitus, optimal medical therapy, percutaneous coronary intervention
  
• ORIGINAL ARTICLES
  Strain, perfusion, and fat in the diabetic heart
  Grigorios Korosoglou1, Prof. Dr. med. and Hugo A. Katus2, Prof. Dr. med. 1GRN Hospital Weinheim, Weinheim, Germany 2Department of Cardiology, University of Heidelberg, Heidelberg, Germany
  
  Keywords: cardiac magnetic resonance, diabetes mellitus, diastolic dysfunction, echocardiography, late gadolinium enhancement, metabolism, myocardial perfusion, spectroscopy
  
• ORIGINAL ARTICLES
  Is glycemic control relevant to cardiovascular clinical outcomes?
  Angelo Avogaro, MD, PhD Department of Medicine, University of Padova, Padova, Italy
  
  Keywords: cardiovascular disease, diabetes mellitus, microvascular complications, risk factors
  
• ORIGINAL ARTICLES
  Trimetazidine effects on preventing cardiovascular events in diabetic patients
  Luis Henrique Wolff Gowdak, MD, PhD, FESC Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
  
  Keywords: diabetes; metabolism; myocardial ischemia; prognosis; trimetazidine
  
• CASE REPORT
  Preventing cardiovascular events in diabetic patients: the case of the patient with poor distal coronary targets
  Elisabetta Salutini, MD; Cristina Bianchi, MD; Roberto Miccoli, MD; Stefano Del Prato, MD, PhD Department of Clinical and Experimental Medicine, Section of Diabetes and Metabolic Diseases, University of Pisa, Italy
  
  Keywords: coronary artery disease, diabetes, glucagon-like peptide-1 agonists, hypoglycemia, incretin, microvascular coronary dysfunction
  
• REFRESHER CORNER
  Diabetic cardiomyopathy, does it exist?
  Heiko Bugger, MD, PhD Heart Center Freiburg University, Freiburg, Germany
  
  Keywords: diabetic cardiomyopathy, diabetes mellitus, heart
  
• HOT TOPICS
  Antidiabetic treatment and cardiovascular events: all a matter of perspective!
  Alda Huqi, MD
  GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  The sensitivity versus specificity trade-off
  Michael Marber, PhD, FRCP
  Read the editorial
  ORIGINAL ARTICLES
  Using biomarkers to obtain mechanistic insight and guide management in acute coronary syndrome
  Kai C. Wollert, MD
  
  Keywords: acute coronary syndrome, acute myocardial infarction, biomarker, cardiac troponin, diagnosis, patient management, prognosis
  
  
  ORIGINAL ARTICLES
  Incorporating high-sensitivity cardiac troponin assays into clinical practice: these assays are your friend
  Sara Love, PhD, Yader Sandoval, MD, Fred S. Apple, PhD
  
  Keywords: biomarkers, cardiac troponin, diagnostic accuracy, high-sensitivity assays, myocardial infarction, outcomes
  
  
  ORIGINAL ARTICLES
  High biomarkers, but normal angiogram: what next?
  Sebastiaan C. A. M. Bekkers, MD, PhD, Martijn W. Smulders, MD
  
  Keywords: acute myocardial infarction, angiography, cardiovascular magnetic resonance imaging, computed tomography, nonobstructed coronary arteries, normal coronary arteries
  
  
  ORIGINAL ARTICLES
  What can we learn from metabolomics?
  Ferheen Baig, MSc, BSc, Manuel Mayr, MD, PhD
  
  Keywords: biomarker, cardiovascular, diabetes, lipidomics, metabolomics
  
  
  ORIGINAL ARTICLES
  Trimetazidine effects on cardiac biomarkers in acute coronary syndrome
  Dr Jamshed Jal Dalal, MD, PhD
  
  Keywords: acute coronary syndrome, cardiac biomarker, metabolic management, trimetazidine
  
  
  CASE REPORT
  Elevated cardiac troponin in a patient with coronary artery disease: why look harder?
  Annette Maznyczka, BSc, MBChB, MRCP, Niharika Varma, BSc, MBBS, Lucy Foote, MBBS, Rupert Williams,
  BSc, MBChB, MRCP, David D’Cruz, MD, FRCP, Valentina O. Puntmann, MD, PhD, MRCP
  
  Keywords: chest pain, magnetic resonance imaging, systemic lupus erythematosus, troponin
  
  
  REFRESHER CORNER
  Defining acute myocardial infarction
  Kai M. Eggers, MD, PhD
  
  Keywords: definition criteria, diagnosis, myocardial infarction, troponin
  
  
  HOT TOPICS
  Metabolic markers in predicting acute cardiovascular events
  Alda Huqi, MD
  GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Hormones and the heart
  G. Jackson
  Read the editorial
• ORIGINAL ARTICLES
  Thyroid, aldosterone, and cardiovascular disease
  C. Vlachopoulos, D. Terentes-Printzios
  
  Keywords: aldosterone, cardiovascular disease, heart failure, hormone, thyroid
  
• ORIGINAL ARTICLES
  Testosterone and cardiovascular disease
  T. Hugh Jones
  
  Keywords: cardiovascular, diabetes, heart, testosterone
  
• ORIGINAL ARTICLES
  Measuring myocardial salvage: hormone cardioprotection
  D. J. Hausenloy
  
  Keywords: acute myocardial infarction, cardiac MRI, cardioprotection, myocardial reperfusion injury, myocardial salvage, PET/MRI
  
• ORIGINAL ARTICLES
  Testosterone and the heart
  C. C. K. Ho, H. M. Tan
  
  Keywords: cardiovascular, metabolic syndrome, testosterone
  
• ORIGINAL ARTICLES
  Effects of trimetazidine on hormones and the heart
  V. Sansoy, K. Kılıçkesmez
  
  Keywords: angina pectoris, cardiac metabolism, coronary artery disease, heart failure, natriuretic peptides
  
• CASE REPORT
  Erectile dysfunction and lower urinary tract symptoms should trigger a metabolic
  screen and cardiovascular risk estimation
  M. Kirby
  
  Keywords: cardiovascular disease, erectile dysfunction, lower urinary tract symptoms, metabolic syndrome, lifestyle
  
• REFRESHER CORNER
  Evaluation of metabolic syndrome and male sexual dysfunction
  J. J. Heidelbaugh, M. M. Miner
  
  Keywords: cardiometabolic risk, erectile dysfunction, male sexual dysfunction, metabolic syndrome
  
• HOT TOPICS
  Testosterone replacement therapy: cardiovascular benefits and possible risks
  G. Hackett
  
  Keywords: cardiovascular disease, elderly, European Male Ageing Study, hypogonadism, men, testosterone, testosterone deficiency syndrome
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  The rapid emergence of microRNAs as a therapeutic target to treat cardiovascular disease
  G. D. Lopaschuk
  Read the editorial
• ORIGINAL ARTICLES
  MicroRNA therapeutics for cardiovascular disease
  E. van Rooij
  
  Keywords: anti-miR, cardiovascular disease, microRNA; miRNA mimic, therapeutics
  
• ORIGINAL ARTICLES
  Targeting microRNAs to promote cardiac repair and cardiomyocyte proliferation as a potential regenerative therapeutic approach
  P. Jakob, U. Landmesser
  
  Keywords: dyspnea; exercise, heart failure, skeletal musculature
  
• ORIGINAL ARTICLES
  Evaluation of microRNAs by molecular imaging for novel diagnostics and therapeutics
  W. Kloos, A. Keller, H. A. Katus, B. Meder
  
  Keywords: biomarker, cardiovascular disease, microRNA, molecular imaging, therapeutic target
  
• ORIGINAL ARTICLES
  The therapeutic potential of microRNAs in heart and vascular diseases
  A. Zampetaki, B. Fanshawe, M. Mayr
  
  Keywords: cardiovascular disease, microRNA, therapeutic application
  
• ORIGINAL ARTICLES
  Nonmetabolic effects of trimetazidine and ventricular remodeling: role in regulatory gene expression
  P. Di Napoli
  
  Keywords: heart failure, mRNA, remodeling, trimetazidine
  
• CLINICAL APPLICATION
  MicroRNA therapy of heart failure
  L. R. Rodino-Klapac
  
  Keywords: antagomiRs, biomarkers, heart failure, microRNAs, miR mimics
  
• REFRESHER CORNER
  What are microRNAs?
  T. Thum
  
  Keywords: cardiac remodeling, cardiovascular disease, heart failure, microRNA
  
• HOT TOPICS
  MicroRNAs as therapeutics for heart disease
  J. R. Ussher
  
  Keywords: cardiovascular disease, heart, heart failure, ischemic heart disease, microRNA, pulmonary arterial hypertension
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Heart failure: a cardiac or a systemic disease?
  M. Marzilli
  Read the editorial
• ORIGINAL ARTICLES
  Heart and muscle, cut from the same striated cloth
  S. von Haehling
  
  Keywords: Heart failure, skeletal muscle, wasting, cachexia
  
• ORIGINAL ARTICLES
  The symptoms of heart failure
  M. Marzilli
  
  Keywords: Dyspnea, exercise, heart failure, skeletal musculature
  
• ORIGINAL ARTICLES
  Imaging of skeletal muscle metabolism in heart failure
  P. Iozzo
  
  Keywords: Exercise, oxidative metabolism, insulin resistance, positron emission tomography, magnetic resonance imaging, muscle composition
  
• ORIGINAL ARTICLES
  Benefits of exercise training for the failing heart
  R. Belardinelli
  
  Keywords: Exercise training, chronic heart failure, outcome
  
• ORIGINAL ARTICLES
  Effects on global metabolism by regulation of substrate utilization in heart failure
  F. Loiacono, C. Silipigni, M. Pagnesi, G. Fragasso
  
  Keywords: heart failure, trimetazidine, left ventricular function, global metabolism, diabetes
  
• CASE REPORT
  Skeletal muscle myopathy in advanced heart failure: a case report
  F. L. Dini, M. C. Scali, A. Simioniuc
  
  Keywords: Heart Failure, Echocardiography, Cardiopulmonary Exercise Test, Skeletal Muscle myopathy, Cardiac Output
  
• REFRESHER CORNER
  How to interpret cardiopulmonary exercise tests
  M. Guazzi
  
  Keywords: cardiopulmonary exercise, oxygen consumption, ventilation inefficiency
  
• HOT TOPICS
  The “skeletal muscle—fat” interplay in heart failure
  A. Huqi
  
  Keywords: heart failure, obesity, skeletal muscle, obesity paradox
  
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  EAT your heart out!
  Michael Marber
  Read the editorial
• ORIGINAL ARTICLES
  Nutrient signaling and cardiovascular aging
  Anna Planavila, Francesc Villarroya, Manlio Vinciguerra
  
  Keywords: Aging, cardiac hypertrophy, cardiomyocytes, cardiomyopathy, cell signaling, growth factors, heart, laminin, mice models, nutrients
  
• ORIGINAL ARTICLES
  Does diet alter cardiovascular risk?
  Ramon Estruch, Gemma Chiva-Blanch
  
  Keywords: Atherosclerosis, cardiovascular disease, cardiovascular risk, diet, infl ammation, Mediterranean diet, olive oil, polyphenols, salt, vegetables, wine
  
• ORIGINAL ARTICLES
  Epicardial adipose tissue: a simple marker of obesity or a complex mediator of cardiovascular disease?
  Ronak Rajani
  
  Keywords: Atherosclerosis, cardiovascular disease, epicardial adipose tissue, pathophysiology
• ORIGINAL ARTICLES
  Gut microbes and cardiometabolic risk
  Max Nieuwdorp
  
  Keywords: Cardiovascular disease, gut microbiota, insulin resistance, obesity
  
• ORIGINAL ARTICLES
  Focus on trimetazidine: effects on diet and the heart
  Roberto Ferrari
  
  Keywords: Adenosine triphosphate, angina, ATP, ATP/O2, β-oxidation, cardiac metabolism, fatty acid oxidation, ischemia, trimetazidine
  
• CASE REPORT
  Resolution of metabolic syndrome after bariatric surgery: a case report
  Rahul K. Mukherjee
  
  Keywords: Angina, breathlessness, diet, gastric bypass, metabolic syndrome, obesity
  
• REFRESHER CORNER
  Basic food composition: is it just sugar and fat?
  Thomas A. B. Sanders
  
  Keywords: Blood pressure, cardiovascular risk, fat, salt, sugar
  
• HOT TOPICS
  The effects of bariatric surgery on the heart
  Oliver J. Rider
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Myocarditis
  Graham Jackson
  Read the editorial
• BASIC ARTICLE
  Myocarditis: the causes
  Uwe Külh
  
  Keywords: Autoimmunity, heart failure, inflammatory cardiomyopathy, myocarditis virus
  
• MAIN CLINICAL ARTICLE
  Management of myocarditis
  Chantal El Amm, Leslie T. Cooper
  
  Keywords: Endomiocardial biopsy, heart failure, myocarditis
  
• METABOLIC IMAGING
  Differentiating infarction from myocarditis
  Eduardo Pozo, Javier Sanz
  
  Keywords: Cardiac imaging techniques, cardiac magnetic resonance, differential diagnosis, myocardial infarction, myocarditis
  
• NEW THERAPEUTIC APPROACHES
  Immunosuppresive therapy in virus-netagive inflammatory cardiomyopathy
  Andrea Frustaci, Cristina Chimenti
  
  Keywords: Heart failure, immunosuppressive therapy, myocarditis, recovery and function, viruses
  
• FOCUS ON
  Metabolic remodeling as a target preventing myocardial dysfunction: focus on trimetazidine
  Alexander N. Parkhomenko, Olga Gurjeva
  
  Keywords: Cardiomyopathy, ischemia, metabolic remodeling, reperfusion, trimetazidine
  
• CASE REPORT
  Multimodality imaging of Churg-Strauss myocarditis
  Amit Sud, Roberta L. Brum, Kelly Victor, Panagiotis Koudounis, Gerald S. Carr-Vhite, Ronak Rajani
  
  Keywords: Cardiac magnetic resonance, Churg-Strauss syndrome, echocardiography, eosinophilic granulomatosis polyangiitis, myocarditis
  
• REFRESHER CORNER
  Myocarditis: inflammatory and endocrine causes
  Alida L.P. Caforio
  
  Keywords: Autoimmunity, diagnosis, dilated cardiomyopathy, endomyocardial biopsy, myocarditis
  
• HOT TOPICS
  Takotsubo cardiomyopathy: a possible metabolic disorder
  Mehmood Zeb, Bushra Naheed, Fahd Irshad, Tim Edwards, Ibrahim M. Ali, Fraser Witherow
  
  Keywords: Takotsubo cardiomyopathy, transient LV apical ballooning, neurogenic stunned myocardium, ampulla cardiomyopathy, stress induced cardiomyopathy, broken heart syndrome, acute catecholamine cardiomyopathy
  
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  The metabolic contribution to heart failure
  Gary D. Lopaschuk
  Read the editorial
• ORIGINAL ARTICLES
  The metabolic basis for the obesity paradox in heart failure
  Stephan von Haehling
  
  Keywords: Heart failure, muscle, obesity, obesity paradox
  
• ORIGINAL ARTICLES
  Is chronic heart failure a reversible metabolic syndrome?
  J. Eduardo Rame
  
  Keywords: Cachexia, cardiac metabolism, chronic heart failure, insulin resistance
  
• ORIGINAL ARTICLES
  Imaging metabolism and perfusion in patients with diabetes and heart failure
  Patricia Iozzo, Maria Angela Guzzardi
  
  Keywords: Cardiac fat, intervention, fatty acid oxidation, magnetic resonance spectroscopy, myocardial insulin resistance, positron emission tomography
  
• ORIGINAL ARTICLES
  Inhibition of fatty acid oxidation as an approach to treat diastolic heart failure
  John R. Ussher, Jagdip S. Jaswal
  
  Keywords: Cardiac energetics, diastolic heart failure, diastolic dysfunction, fatty acid oxidation
  
• ORIGINAL ARTICLES
  Use of trimetazidine to treat diabetes patients with heart failure
  Rui Yan, Dengfeng Gao
  
  Keywords: Energy metabolism, heart failure, trimetazidine
  
• CASE REPORT
  Dramatic loss of weight in an obese patient with heart failure:
  a mighty heart in a big man
  Vitantonio Di Bello, Lorenzo Conte, Iacopo Fabiani, Valentina Barletta, Letizia Pieruzzi,
  Giovanna Scartabelli, Ferruccio Santini
  
  Keywords: Echocardiography, heart failure, natriuretic peptides, obesity
  
• REFRESHER CORNER
  Energy metabolic changes in the diabetic heart
  Lionel H. Opie
  
  Keywords: Fatty acid oxidation, hyperglycemia, insulin resistance, metabolic syndrome
  
• HOT TOPICS
  Irisin, a novel myokine: potential role in obesity and diabetes
  Andrew G. Swick
  
  Keywords: Brown adipose tissue,energy expenditure,irisin,myokine
  
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Inflammation in atherosclerosis: casualty or causality?
  M. Marber
  Read the editorial
• ORIGINAL ARTICLES
  Macrophages: cause or cure in atherosclerosis?
  M. Bennett
  
  Keywords: Apoptosis, atherosclerosis, inflammation, macrophages
  
• ORIGINAL ARTICLES
  The role of inflammation in atherosclerosis:
  what we have learned from clinical trials?
  M. Al-Hawwas, J.-F. Tanguay
  
  Keywords: Atherosclerosis, coronary artery disease, inflammation
  
• ORIGINAL ARTICLES
  Metabolic imaging: imaging plaques
  F. R. Joshi, M. Chowdhury, J. H. F. Rudd
  
  Keywords: Atherosclerosis, fluorodeoxyglucose, inflammation, non invasive imaging
  
• ORIGINAL ARTICLES
  Secretory phospholipase: a potential target for cardiovascular therapies
  S. J. Nicholls, M. Duong
  
  Keywords: Cardiovascular disease, inflammation, risk factor, sPLA2
  
• ORIGINAL ARTICLES
  Trimetazidine effects on oxidative damage
  S. J. Hong
  
  Keywords: Myocardial infarction, oxidative damage, trimetazidine
  
• CASE REPORT
  Psoriasis and risk of cardiovascular disease: case report and discussion
  C. Maybury, C. H. Smith
  
  Keywords: Psoriasis, inflammation, skin disease, cardiovascular disease, anti-TNF therapy
  
• REFRESHER CORNER
  Innate immunity: an integrated overview
  S. G. Shaw
  
  Keywords: C-type lectin receptors, innate immunity, NOD-like receptors, RIG-1-like receptors, Toll-like receptors
  
• HOT TOPICS
  Can infective agents be respectable etiopathogenetic factors for acute coronary syndromes?
  A. Huqi
  
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Where is the resistance?
  M. Marzilli
  Read the editorial
• BASIC ARTICLE
  Pressure drops along coronary vasculature
  G. Guarini and M. Marzilli
  
  Keywords: Coronary microvasculature, coronary resistance, coronary stenosis, perfusion pressure
  
• MAIN CLINICAL ARTICLE
  Integrated control of coronary microvascular tone: in series mechanisms for a differential regulation of flow and capillary pressure
  G. Sambuceti, S. Capitanio and C. Marini
  
  Keywords: Atherosclerosis, coronary blood flow, coronary microcirculation, endothelium, 1-25-dihydroxyvitamin D, parathyroid hormone
  
• METABOLIC IMAGING
  Magnetic resonance imaging perfusion to assess transmural flow distribution
  A. Chiribiri and E. Nagel
  
  Keywords: Adenosine, coronary disease, fractional flow reserve, high-resolution quantification, magnetic resonance imaging, perfusion
  
• NEW THERAPEUTIC APPROACHES
  Do we need to lower coronary resistances?
  B. I. Lévy
  
  Keywords: Coronary reserve, coronary flow, capillary density, hemorheology, myocardial perfusion, pharmacology, vasodilatation
  
• FOCUS ON TRIMETAZIDINE (VASTAREL® MR)
  Trimetazidine effects on restoring endothelial function
  K.-H. Park
  
  Keywords: Endothelium, nitric oxide, oxidative stress, trimetazidine
  
• CASE REPORT
  “Resistance in the cath lab”: the utility of hyperemic stenosis resistance in the functional assessment of coronary artery disease
  K. De Silva and D. Perera
  
  Keywords: Fractional flow reserve, functional assessment, hyperemic stenosis resistance, microvascular resistance
  
• REFRESHER CORNER
  Impact of myocardial function on perfusion
  G. Guarini
  
  Keywords: Coronary autoregulation, coronary metabolic dilation, coronary microcirculation, myocardial function, myocardial perfusion
  
• HOT TOPICS
  Coronary arterial system: pathophysiological hints from large clinical trials
  A. Huqi
  
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Re-evaluating revascularization
  M. Marber
  Read the editorial
• BASIC ARTICLE
  Coronary flow and physiology beyond the stenosis
  M. Siebes
  
  Keywords: Control of coronary blood flow, coronary artery stenosis, coronary microcirculation, myocardial perfusion
  
• MAIN CLINICAL ARTICLE
  Does revascularization work?
  M. S. Sidhu and W. E. Boden
  
  Keywords: Coronary artery disease, myocardial revascularization, optimal medical therapy, stable ischemic heart disease
  
• METABOLIC IMAGING
  Imaging myocardial edema
  D. P. O’Regan and S. A. Cook
  
  Keywords: Acute myocardial infarction, cardiovascular magnetic resonance, myocardial salvage
  
• NEW THERAPEUTIC APPROACHES
  Angiogenic therapy: is it still viable?
  C. Seiler
  
  Keywords: Angiogenesis, arteriogenesis, collateral circulation, coronary circulation
  
• FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
  Metabolic cardiac protection is beneficial in patients undergoing coronary revascularization: is it necessary afterwards?
  Y. Lopatin
  
  Keywords: coronary artery bypass grafting (CABG), metabolic cardioprotection, percutaneous coronary intervention (PCI), trimetazidine
  
• CASE REPORT
  Coronary artery disease: two sides of the same coin
  P. Capozza and G. Todiere
  
  Keywords: Acute coronary syndrome, coronary angiography, fractional flow reserve
  
• REFRESHER CORNER
  History of coronary revascularization
  S. B. King
  
  Keywords: Coronary angioplasty, coronary artery bypass graft surgery, percutaneous coronary intervention, revascularization stenting
  
• HOT TOPICS
  Revascularization and optimal medical therapy: shattering new evidence
  A. Huqi
  
  
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  The challenge of treating diastolic heart failure
  G. D. Lopaschuk
• BASIC ARTICLE
  Differentiating diastolic dysfunction from classic heart failure
  J. S. Jaswal and J. R. Ussher
  
  Keywords: Cardiac energetics, diabetic cardiomyopathy, diastolic dysfunction, heart failure, obesity
• MAIN CLINICAL ARTICLE
  Advances in the treatment of heart failure with preserved systolic function
  K. J. Lyons and J. A. Ezekowitz
  
  Keywords: Diastolic, drug therapy, heart failure, randomized controlled trials as topic
• METABOLIC IMAGING
  Diastolic dysfunction: improved understanding using emerging imaging techniques
  F. L. Dini
  
  Keywords: Diastolic function, left ventricular filling pressure, tissue Doppler imaging, strain analysis
• NEW THERAPEUTIC APPROACHES
  Metabolic therapy for heart failure including diastolic heart failure
  N. Siddiqi, D. Dawson, A. Rudd and M. Frenneaux
  
  Keywords: Cardiac energetics, cardiac metabolism, cardiomyopathy, heart failure, metabolic therapy
• FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
  New pharmacological targets in the treatment of heart failure:
  inhibition of free fatty oxidation by trimetazidine
  N. Signoretta, L. Alberti, L. Lauretta, B. Demarchi, F. Loiacono, A. Margonato and G. Fragasso
  
  Keywords: Carnitine palmitoyl transferase I, free fatty acid inhibitors, heart failure, left ventricular function, metabolic therapy, myocardial metabolism, trimetazidine
• CASE REPORT
  Acute shortness of breath and chest tightness in an elderly patient:
  clinical history tells it best!
  A. Huqi
  
  Keywords: Comorbidities, comprehensive evaluation, diastolic dysfunction, diastolic heart failure, non invasive assessment
• REFRESHER CORNER
  How the heart relaxes
  N. Fillmore and G. D. Lopaschuk
  
  Keywords: Calcium; diastole, sarcomere, sarcoplasmic reticulum
• HOT TOPICS
  The undisputed principles of myocardial ischemia!
  A. Huqi
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  The heart of an athlete
  G. Jackson
• BASIC ARTICE
  Physiological versus pathological left ventricular hypertrophy
  T. Kotecha, K. Fox
  
  Keywords: left ventricular hypertrophy, hypertrophic cardiomyopathy, athlete’s heart, echocardiography
• MAIN CLINICAL ARTICLE
  Clinical evaluation of the athlete
  A. Cox, S. Sharma
  
  Keywords: arrhythmias, athlete’s heart, clinical evaluation, physiological adaptations, sudden cardiac death
• METABOLIC IMAGING
  Athlete’s heart or hypertrophic cardiomyopathy
  R.H. Fagard
  
  Keywords: athlete’s heart, hypertrophic cardiomyopathy, echocardiography, endurance training, static training
• NEW THERAPEUTIC APPROACHES
  To train or not to train? That is the question
  A.L. Baggish
  
  Keywords: athlete’s heart, cardiomyopathy, exercise physiology, overuse injury
• FOCUS ON TRIMETAZIDINE (Vastarel® MR)
  The improvement of trimetazidine on exercise performance in ischemic
  heart disease
  Y. Chen
  
  Keywords: trimetazidine (TMZ), ischemic heart disease (IHD), exercise capacity, exercise performance;quality of life (QOL), left ventricular ejection fraction (LVEF)
• CASE REPORT
  Life saving pre-participation athletic screening
  M. Elmaghawry, A. Zorzi, M. Perazzolo Marra, D. Corrado
  
  Keywords: arrhythmogenic right ventricular cardiomyopathy, electrocardiogram, pre-participation screening, implantable cardioverter defibrillator, sports cardiology
• REFRESHER CORNER
  Effects of performance-enhancing drugs on cardiac structure
  and energy metabolism
  J.R. Ussher, J.S. Jaswal
  
  Keywords: performance-enhancing drugs, anabolic androgenic steroids, human growth hormone, left ventricular hypertrophy, cardiac energy metabolism
• HOT TOPICS
  Clinical assessment of revascularized patients
  A. Huqi
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Talking ‘omics
  M. Marber
• BASIC ARTICLE
  Proteomics and microRNA profiling in cardiac fibrosis
  J. Barallobre-Barreiro, A. Didangelos, M. Mayr
  
  Keywords: cardiac fibrosis, fibroblasts, proteomics, miRNAs
• MAIN CLINICAL ARTICLE
  Metabolomics in coronary heart disease
  D. J. Grainger, D. E. Mosedale
  
  Keywords: diagnostics, atherosclerosis, profiling, multivariate statistics
• METABOLIC IMAGING
  Dynamic nuclear polarization and MRI for the study of cardiac metabolism
  T. R. Eykyn, R. Southworth, S. Kozerke
  
  Keywords: dynamic nuclear polarization, MRI, cardiac metabolism, 13C
• NEW THERAPEUTIC APPROACHES
  Genomic prediction of individual drug response
  L. Mestroni
  
  Keywords: pharmacogenomics, genetic variation, cardiovascular genetics, drug response, heart failure
• FOCUS ON TRIMETAZIDINE (Vastarel® MR)
  Efficacy of trimetazidine: lessons from meta-analyses
  J. P. Ribeiro
  
  Keywords: coronary artery disease, angina, heart failure, left ventricular function, functional capacity
• CASE REPORT
  Assay what? The troponin masqueraders—a case report
  J. O. Baker, K. De Silva
  
  Keywords: acute myocardial infarction, cardiac troponin, assay interference, heterophile antibodies, delta change
• REFRESHER CORNER
  Fundamentals of genome-wide association studies
  M. Mangino
  
  Keywords: genome-wide association, complex disease, single nucleotide polymorphisms (SNP), linkage disequilibrium
• HOT TOPICS
  The struggles of translational medicine in ischemia-reperfusion injury
  A. Huqi
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Cardiac protection in acute cardiac syndrome
  M. Marzilli
• BASIC ARTICLE
  Magnitude and relevance of reperfusion injury
  D. J. Hausenloy
  
  Keywords: myocardial reperfusion injury, primary percutaneous coronary intervention (PPCI), ST-segment elevation myocardial infarction (STEMI)
• MAIN CLINICAL ARTICLE
  Pharmacological cardiac protection
  E. Orsini, M. Marzilli, D. Morrone, P. Capozza, A. Huqi, F. L. Dini, and G. Guarini
  
  Keywords: ischemia-reperfusion injury, cardioprotection, preconditioning, postconditioning, mitochondrial permeability transition pore, adenosine
• METABOLIC IMAGING
  Magnetic resonance imaging of the microcirculation in acute coronary syndromes
  K. De Silva, J. Baker, A. Kidambi, D. Perera and S. Plein
  
  Keywords: microvascular dysfunction, magnetic resonance imaging (MRI), acute coronary syndrome, myocardial infarction
• NEW THERAPEUTIC APPROACHES
  Postconditioning
  M. Marzilli, D. Morrone and G. Guarini
  
  Keywords: ischemia reperfusion injury, cardioprotection, post-conditioning, remote conditioning
• FOCUS ON Vastarel® MR
  Metabolic cardiac protection
  G. Guarini
  
  Keywords: cardiac ischemia, ischemia/reperfusion injury, cardioprotection, trimetazidine
• CASE REPORT
  Myocardial infarction with contemporary bivasal occlusion: one case, two fates
  P. Capozza and M. Marzilli
  
  Keywords: myocardial infarction, adenosine, cardioprotection, microcirculation
• REFRESHER CORNER
  Myocytes versus endothelial damage
  F. L. Dini, E. Orsini, M. Marzilli and G. Guarini
  
  Keywords: ischemic injury, reperfusion injury, endothelial damage, cardioprotection
• HOT TOPICS
  The heart failure and obesity paradox: would you suggest your patients gain weight?
  A. Huqi
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Energetics in heart disease
  D. Feuvray
• BASIC ARTICLE
  Myocardial energetics and efficiency
  E. Aasum
  
  Keywords: cardiac energy metabolism, oxygen consumption, mechano energetics, heart failure
• MAIN CLINICAL ARTICLE
  Modulation of cardiac energetics as a target in ischemic heart disease
  H. Ashrafian
  
  Keywords: cardiac energetics, ischemic heart disease, metabolic therapies, cardiac metabolism
• METABOLIC IMAGING
  Glucose metabolism as a marker of myocardial ischemia
  P. G. Camici
  
  Keywords: coronary artery disease, myocardial metabolism, myocardial ischemia, positron emission tomography.
• NEW THERAPEUTIC APPROACHES
  An expanded role for AMP kinase: self-renewal of the cardiomyocyte
  K. Baskin and H. Taegtmeyer
  
  Keywords: AMPK, protein degradation, cardiac metabolism
• FOCUS ON TRIMETAZIDINE (Vastarel® MR)
  Beneficial effects of trimetazidine (Vastarel® MR) in patients with chronic heart failure
  G. Fragasso, L. Alberti and L. Lauretta
  
  Keywords: systolic-dysfunction, heart failure, left ventricular function, metabolic therapy, energy expenditure
• CASE REPORT
  Myocardial power delivery is impaired in progressive left ventricular pump failure: a case report
  F. L. Dini
  
  Keywords: heart failure, dilated cardiomyopathy, echo stress
• REFRESHER CORNER
  Impact of fatty acid oxidation on cardiac efficiency
  N. Fillmore and G. D. Lopaschuk
  
  Keywords: fatty acid ß-oxidation, uncoupling proteins, mitochondrial thioesterase, glucose oxidation, glycolysis
• HOT TOPICS
  Statin therapy: reduction in cardiovascular events still pays in new-onset diabetes
  A. Huqi
• GLOSSARY
  G. D. Lopaschuk

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• EDITORIAL
  Equality of care for the elderly
  Graham Jackson
• BASIC ARTICLE
  Energy metabolism in the aging heart
  Jason R.B. Dyck, Miranda M.Y. Sung
  
  Keywords: aging, myocardial metabolism, contractile dysfunction, mitochondria
• MAIN CLINICAL ARTICLE
  Managing angina in the elderly: the impact of comorbidities
  Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Christodoulos Stefanadis
  
  Keywords: elderly, coronary artery disease, angina; comorbidities
• METABOLIC IMAGING
  Cardiac computed tomography in the elderly: windows into a lifetime of exposure to cardiac risk
  Gary R. Small, Benjamin J.W. Chow, Terrence D. Ruddy
  
  Keywords: cardiac CT, coronary calcification, risk stratification, elderly
• NEW THERAPEUTIC APPROACHES
  Transcatheter aortic valve implantation in the elderly: current state of play
  Aung Myat, Muhammed Zeeshan Khawaja, Hari Haran, Kaleab Asrress, Simon Redwood
  
  Keywords: TAVI, aortic stenosis, transfemoral, transapical, stroke, surgical AVR
• FOCUS ON VASTAREL® MR
  Quality of life with trimetazidine
  Giuseppe Marazzi
  
  Keywords: ischemic cardiomyopathy, trimetazidine, quality of life
• CASE REPORT
  Metabolic approach to ischemic heart disease in the elderly
  Cristiana Vitale
  
  Keywords: elderly, ischemic heart disease, arterial peripheral disease, trimetazidine
• REFRESHER CORNER
  Improving the quality of sex life in the elderly
  J.M. Tomlinson
  
  Keywords: ageing, sex life, elderly, PDE5 inhibitors, hormone replacement therapy, retirement homes
• HOT TOPICS
  Medical therapy versus revascularization rounds: ischemic heart failure on focus
  Alda Huqi
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  The rising tide of cardiotoxicity associated with cancer chemotherapy
  Gary D. Lopaschuk
• BASIC ARTICLE
  Cardiotoxicity in cancer therapeutics
  Christian Zuppinger
  
  Keywords: cancer therapy, cardiotoxicity, anthracyclines, cell death, mitochondria
• MAIN CLINICAL ARTICLE
  Assessing and monitoring cardiac function in cancer patients
  K. von Klemperer, K. Fox
  
  Keywords: cancer, chemotherapy, heart failure, cardiotoxicity
• METABOLIC IMAGING
  Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer
  Mukesh K. Pandey, Aditya Bansal, Timothy R. DeGrado
  
  Keywords: PET, fatty acid oxidation, thia fatty acid, FTHA, FTP, FTO
• NEW THERAPEUTIC APPROACHES
  Metabolic modulation as a novel cancer treatment
  Peter Dromparis, Gopinath Sutendra, Evangelos D. Michelakis
  
  Keywords: cancer, metabolic, apoptosis, dichloroacetate, glycolysis
• FOCUS ON VASTAREL® MR
  Cancer and inhibition of fatty acid oxidation
  Alda Huqi
  
  Keywords: cancer, Warburg effect, metabolic modulation therapy, fatty acid oxidation
• CASE REPORT
  A case of multifactorial late left ventricular dysfunction after cancer treatment
  Chiara Lestuzzi
  
  Keywords: cardiotoxicity, radiotherapy, left ventricular dysfunction, Hodgkin’s disease, coronary artery disease, dyslipidemia
• REFRESHER CORNER
  The Warburg effect – aerobic glycolysis in proliferating cells
  Jagdip S. Jaswal
  
  Keywords: cellular proliferation, glycolysis, glucose oxidation, cellular biosynthesis
• HOT TOPICS
  Warfarin and dabigatran: an historical handover?
  Alda Huqi

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• EDITORIAL
  Changing epidemiology of ischemic heart disease
  Mario Marzilli
• BASIC ARTICLE
  Emerging patterns in IHD in developing countries
  Raffaele Bugiardini
  
  Keywords: Epidemiology, Europe, ISACS-CT, ischemic heart disease, MONICA
• MAIN CLINICAL ARTICLE
  The changing face of acute coronary syndromes
  Steven E. Williams, Christopher N. Floyd, Michael Marber
  
  Keywords: Acute coronary syndrome, angiography, angioplasty, myocardial infarction, non-ST-segment elevation, NSTEMI, percutaneous intervention, revascularization, STEMI, ST-segment elevation
• METABOLIC IMAGING
  Detecting acute coronary syndromes by magnetic resonance imaging
  Afshin Farzaneh-Farab, Raymond Y. Kwongc
  
  Keywords: Acute coronary syndrome, chest pain, magnetic resonance imaging, myocardial infarction, unstable angina
• NEW THERAPEUTIC APPROACHES
  Stable angina and female gender
  Alda Huqi, Paola Capozza, Mario Marzilli
  
  Keywords: Coronary artery disease, gender differences, ischemic heart disease
• FOCUS ON VASTAREL® MR
  Clinical benefits of trimetazidine (Vastarel® MR) in the changing scenario of ischemic heart disease
  Elena Louette
  
  Keywords: Cardiac energy metabolism, cardioprotection, diabetes, IHD, LV dysfunction, trimetazidine MR
• CASE REPORT
  Coronary microcirculation in effort ischemia: the roar of the rabbit
  Paola Capozza, Enrico Orsini
  
  Keywords: Coronary angiography, coronary slow flow, myocardial ischemia
• REFRESHER CORNER
  Lessons from EUROASPIRE I, II, and III surveys
  Kornelia Kotseva
  
  Keywords: Cardiovascular disease (CVD), coronary heart disease (CHD), EUROASPIRE, lifestyle and risk-factor management
• HOT TOPICS
  Interventional therapy for resistant hypertension: new hopes and old concerns!
  Alda Huqi
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Dilated cardiomyopathy
  G. Jackson
• BASIC ARTICLE
  Myocardial energy metabolism in dilated cardiomyopathy
  W. C. Stanley
  
  Keywords: fatty acids, glucose, heart failure, mitochondria
• MAIN CLINICAL ARTICLE
  Drugs and/or devices in dilated cardiomyopathy
  H. P. Schultheiss, U. Kühl
  
  Keywords: Anti-viral or immunomodulatory treatment, autoimmunity, dilated cardiomyopathy,heart failure therapy, ICD, immunosuppression, myocarditis
• METABOLIC IMAGING
  Metabolic imaging in dilated cardiomyopathy
  S. Neubauer
  
  Keywords: Dilated cardiomyopathy, energetics, magnetic resonance spectroscopy, metabolism, steatosis
• NEW THERAPEUTIC APPROACHES
  Metabolic modulation in dilated cardiomyopathy
  H. Tuunanen, J. Knuuti
  
  Keywords: etomoxir, Heart failure, metabolism, perhexiline, trimetazidine
• FOCUS ON VASTAREL MR
  The clinical benefits provided by trimetazidine in left ventricular dysfunction patients
  G Marazzi, G. Caminiti, M. Voterrani
  
  Keywords: Chronic heart failure, left ventricular function, metabolic therapy, trimetazidine
• CASE REPORT
  Response to cardiac resynchronization therapy resulting from an upgrade to dual-site left ventricular pacing
  M. R. Ginks, S. G. Duckett, G. S. Carr-White, C. A. Rinaldi
  
  Keywords: Cardiac resynchronization therapy, multi-site pacing, non-responder
• REFRESHER CORNER
  Cardiac amyloidosis
  P. Schmidheiny, O. M. Hess
  
  Keywords: Autologous stem cell transplantation, cardiac amyloidosis, cardiac arrhythmias, endomyocardial biopsy, restrictive cardiomyopathy
• HOT TOPICS
  Low diagnostic yield of coronary angiography or not catching up with heart disease pathophysiology?
  A Huqi
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Obesity and heart disease
  Gary D. Lopaschuk
• BASIC ARTICLE
  Free fatty acid oxidation in insulin resistance and obesity
  E. Dale Abel
• MAIN CLINICAL ARTICLE
  Obesity and mortality: summary of best evidence with explanations for the obesity paradox
  Jennifer Logue, Naveed Sattar
• METABOLIC IMAGING
  Functional imaging of brown adipose tissue
  Kirsi A. Virtanena, Pirjo Nuutilaab
• NEW THERAPEUTIC APPROACHES
  Stimulating brown fat: a potential future therapeutic approach for obesity and insulin resistance?
• FOCUS ON VASTAREL MR
  Clinical benefits of trimetazidine in diabetic patients with coronary artery disease
  Samir S. Wafa
• CASE REPORT
  Comorbidity in the obese patient: the paroxysmal Pickwickian with pulmonary peculiarities and poor pump performance
  Ian G. Webb, Michael Marber
• REFRESHER CORNER
  Mitochondrial uncoupling proteins
  Frédéric Bouillaud
• Hot topics
  Risk factor modification and cardiovascular events: the gap is not yet bridged
  Alda Huqi
• Hot topics
  Abstracts and Commentaries: A new link between obesity and heart disease
  Danielle Feuvray
• Glossary
  Gary D. Lopaschuk

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• EDITORIAL
  What becomes of the brokenhearted?
  Michael Marber
• BASIC ARTICLE
  Basic mechanisms in apoptosis and heart failure
  Roger Foo
• MAIN CLINICAL ARTICLE
  Role of RAAS inhibition in preventing left ventricular remodeling in patients post myocardial infarction
  Doralisa Morrone, Mario Marzilli
• METABOLIC IMAGING
  Magnetic resonance imaging to assess ventricular remodeling
  Otavio R. Coelho-Filhoa, Raymond Y. Kwonga, Michael Jerosch-Heroldb
• NEW THERAPEUTIC APPROACHES
  Toll-like receptors: emerging therapeutic targets for heart failure
  Stefan Frantz, Johann Bauersachs
• FOCUS ON VASTAREL MR
  Clinical overview of trimetazidine (Vastarel MR) in patients with heart failure
  Tiina Uuetoa
• CASE REPORT
  Left ventricular remodeling after acute myocardial infarction with microvascular obstruction
  Robin Nijveldt, Albert C. van Rossum
• REFRESHER CORNER
  Ivabradine (Procoralan) alone or with ß-blockers in myocardial ischemia
  Alain Berdeaux
• HOT TOPICS
  Strategies to prevent left ventricular remodeling
  Alda Huqi
• HOT TOPICS
  Early diagnosis of myocardial infarction
  Michael Marber
• GLOSSARY
  Gary D. Lopaschuk
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• EDITORIAL
  The cardiac cell: its survival and performance
  Mario Marzilli
• Evolution of the metabolic approach to heart disease
  Vaninder K. Sidhu, Gary D. Lopaschuk
• Cardiac metabolism in the diabetic patient
  Danielle Feuvray
• Cardiomyopathies and heart failure
  Lionel H. Opie
• The winding road to cardioprotection
  Rupert Williams, Michael Marber
• Cardioprotective therapy in reperfusion injury: lessons from the European Myocardial Infarction Project – Free Radicals (EMIP-FR)
  Mario Marzilli, Alda Huqi
• Stable angina: treatment selection
  Graham Jackson
• Vastarel MR: from decades of clinical experience in stable angina to new perspectives
  Mario Marzilli

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• EDITORIAL
  Diabetes and cardiovascular disease
  Gary D. Lopaschuk
• BASIC ARTICLE
  Non ischemic heart failure in diabetes mellitus: still incompletely understood
  Romain Harmancey, Heinrich Taegtmeyer
• MAIN CLINICAL ARTICLE
  Clinical manifestations of diabetic cardiomyopathy
  Sihem Boudina
• METABOLIC IMAGING
  Nuclear magnetic resonance for the study of cardiac metabolism in diabetes
  Giancarlo Todiere, Mario Marzilli
• NEW THERAPEUTIC APPROACHES
  Cardiac considerations in the treatment of the metabolic syndrome
  David S.H. Bell
• FOCUS ON VASTAREL MR
  Clinical benefits of trimetazidine in patients with coronary artery disease and diabetes mellitus
  Luis Rodríguez Padial
• CASE REPORT
  Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis
  Maurizio Galderisi, Rosa Raia
• EDITORIAL COMMENT
  Editorial comment to the article “Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis” by Maurizio Galderisi and Rosa Raia
  Mario Marzilli
• REFRESHER CORNER
  Energy metabolism in the heart of the diabetic patient
  Danielle Feuvray
• FEATURED RESEARCH
  Abstracts and Commentaries
  Jagdip S. Jaswal, Gary D. Lopaschuk
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Circadian rhythms and cardiovascular disease
  Danielle Feuvray
• BASIC ARTICLE
  Diurnal variations in myocardial metabolism
  Ju-Yun Tsai, Martin E. Young
• MAIN CLINICAL ARTICLE
  Disruption of normal circadian rhythms and cardiovascular events
  Alberto Dominguez-Rodrigueza, Pedro Abreu-Gonzalezb, Juan Carlos Kaskic
• METABOLIC IMAGING
  Metabolic imaging with cardiac magnetic resonance spectroscopy
  Stefan Neubauer
• NEW THERAPEUTIC APPROACHES
  Rev-erba: a potential target for the treatment of circadian disorders
  Hélène Duezabcd, Bart Staelsabcd
• FOCUS ON VASTAREL MR
  Beneficial effects of Vastarel MR in protecting patients with stable coronary artery disease against early morning ischemic burden
  Stephane Coquempot
• CASE REPORT
  Jet lag
  Graham Jackson
• REFRESHER CORNER
  Melatonin and cardiac pathophysiology
  Russel J. Reiter, Dun X. Tan
• FEATURED RESEARCH
  Abstracts and Commentaries
  Mario Marzilli
• GLOSSARY
  Gary D. Lopaschuk

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• TO OUR READERS
  Change of Editor-in-Chief of Heart and Metabolism
• EDITORIAL
  Biomarkers: past, present and future
  Graham Jackson
• BASIC ARTICLE
  The biological basis of troponin in heart disease: possible uses for troponin fragmentology
  Vlad C. Vasile, Allan S. Jaffe
• MAIN CLINICAL ARTICLE
  The role of biomarkers in clinical practice
  Anthony S. Wierzbickia, Adie Viljoenb
• METABOLIC IMAGING
  Troponin compared with late enhancement in the assessment of myocardial injury
  Evangelos Giannitsis, Hugo A. Katus
• NEW THERAPEUTIC APPROACHES
  Trends in genomic biomarkers
  Bruce McManus
• FOCUS ON VASTAREL MR
  Effects of Vastarel MR on brain natriuretic peptide and cardiac troponin concentrations
  Pericle Di Napoli
• CASE REPORT
  Serial determination of troponin concentrations in the diagnosis of acute myocardial infarction
  Vlad C. Vasile, Lori A. Blauwet, Allan S. Jaffe
• REFRESHER CORNER
  Temporal profile of protein release in myocardial infarction
  Piero Montorsi, Marco Villa, Maria Antonietta Dessanai
• FEATURED RESEARCH
  Abstracts and Commentaries
  Mario Marzilli
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Chronic ischemic heart disease
  Mario Marzilli
• BASIC ARTICLE
  Genomics, transcriptomics, and proteomics of the ischemic heart
  Marcus C. Schauba, Eliana Lucchinettib, Michael Zauggb
• MAIN CLINICAL ARTICLE
  Identifying patients at risk of progressive left ventricular dysfunction
  Florence Pinet
• METABOLIC IMAGING
  Magnetic resonance imaging and positron emission tomography as predictors of heart failure
  Christoph Klein
• NEW THERAPEUTIC APPROACHES
  Targeting oxidative stress in heart failure
  Leong L. Ng
• FOCUS ON VASTAREL MR
  Beneficial long-term effects of Vastarel MR in patients with stable coronary artery disease developing left ventricular dysfunction
  Hamayak S. Sisakian
• CASE REPORT
  Changing ischemic symptoms despite stable coronary anatomy
  Mario Marzilli, Alda Huqi
• REFRESHER CORNER
  Hibernation or repetitive stunning – does it matter?
  Gerd Heuscha, Rainer Schulzb
• The clinical perspective
  I. Rahman, R.S. Bonser
• FEATURED RESEARCH
  Abstracts and Commentaries
  Danielle Feuvray
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Taking genes to heart
  Michael S. Marber
• BASIC ARTICLE
  Genetics of cardiomyopathy and channelopathy
  Connie R. Bezzina
• MAIN CLINICAL ARTICLE
  What the practicing cardiologist needs to know about genetics and heart disease
  Rahul C. Deo, Calum A. MacRae
• METABOLIC IMAGING
  Imaging of myocardial receptors: applications in the evaluation of cardiac disease
  Ornella Rimoldiabc, Paolo G. Camiciab
• NEW THERAPEUTIC APPROACHES
  Gene therapy for cardiovascular manifestations of lysosomal storage diseases
  Meg M. Sleepera, Mark E. Haskinsb, Katherine P. Ponderc
• FOCUS ON VASTAREL MR
  Anti-ischemic cardioprotection with trimetazidine
  Pericle Di Napoli
• CASE REPORT
  Long-QT syndrome in a family with a KCNH2 mutation
  Cliona Murphy, Jas Gill
• REFRESHER CORNER
  How do mutations cause disease?
  Jean-Jacques Mercadier
• FEATURED RESEARCH
  Abstracts and commentaries
  Mario Marzilli
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Coronary microvascular disease
  Mario Marzilli
• BASIC ARTICLE
  Microvascular control of myocardial perfusion
  Helmut Habazettl, Axel R. Pries
• MAIN CLINICAL ARTICLE
  Prognostic significance of microvascular dysfunction
  Michael Weis
• METABOLIC IMAGING
  Non invasive assessment of coronary microvascular dysfunction
  Frans Visser
• NEW THERAPEUTIC APPROACHES
  Improving perfusion at reperfusion
  Mario Marzilli
• FOCUS ON VASTAREL MR
  Reperfusion injury: reduction by Vastarel MR
  Laurent Bonello, Franck Paganelli
• CASE REPORT
  Microvascular obstruction after primary angioplasty: beyond the epicardial artery
  Tim Lockie, Sven Plein, Simon Redwood
• REFRESHER CORNER
  Cardiac syndrome X: pathogenesis and management
  Juan Carlos Kaski, Kamran Iqbal
• FEATURED RESEARCH
  Abstracts and commentaries
  Mario Marzilli
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Measuring cardiac efficiency: is it clinically useful?
  Frans Visser
• BASIC ARTICLE
  Molecular basis of cardiac efficiency
  Heiko Bugger, E. Dale Abel
• MAIN CLINICAL ARTICLE
  Assessment and clinical applications of myocardial efficiency
  Olakunle Akinboboye
• METABOLIC IMAGING
  Myocardial efficiency in heart failure: non invasive imaging
  Paul Knaapen, Tjeerd Germans
• NEW THERAPEUTIC APPROACHES
  Improvement of cardiac efficiency in heart failure by cardiac resynchronization therapy
  Matthew Ginks, C. Aldo Rinaldi
• FOCUS ON VASTAREL MR
  Benefits of the metabolic approach in cardiac rehabilitation
  Romualdo Belardinelli
• CASE REPORT
  Improvement of myocardial efficiency in a patient with hypertrophic obstructive cardiomyopathy after alcohol septal ablation
  Tjeerd Germans12*, Paul Knaapen1, Albert C. van Rossum12
• REFRESHER CORNER
  Invasive assessment of cardiac efficiency
  Paul Steendijk, Ellen A. ten Brinke
• FEATURED RESEARCH
  Abstracts and commentaries
  Danielle Feuvray
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Stable angina – taking time
  Graham Jackson
• BASIC ARTICLE
  Optimizing cardiac energy substrate metabolism: a novel therapeutic intervention for ischemic heart disease
  Jagdip S. Jaswal, Virgilio J.J. Cadete, Gary D. Lopaschuk
• MAIN CLINICAL ARTICLE
  Stable angina: a balanced approach
  Jon-David Schwalm, Koon K. Teo
• METABOLIC IMAGING
  Magnetic resonance perfusion imaging for detection of ischemic heart disease
  Eike Nagel
• NEW THERAPEUTIC APPROACHES
  Coronary microcirculation: the new frontier in coronary artery disease
  Mario Marzilli
• FOCUS ON VASTAREL MR
  Efficacy of Vastarel MR on silent and symptomatic myocardial ischemia
  Giuseppe Caminiti, Giuseppe Marazzi, Giuseppe Rosano
• CASE REPORT
  Trimetazidine in the management of ischemic heart disease in a patient with diabetes mellitus and recurrent angina
  Mario Marzilli
• REFRESHER CORNER
  The place of exercise in the patient with chronic stable angina
  Anil Nigam, Jean-Claude Tardif
• FEATURED RESEARCH
  Abstracts and commentaries
  Danielle Feuvray
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Go with the flow
  Michael Marber
• BASIC ARTICLE
  Consequences of reperfusion
  Thorsten Reffelmann and Robert A. Kloner
  
  Keywords: Ischemic preconditioning, myocardial salvage, no reflow, reperfusion, stunning
• MAIN CLINICAL ARTICLE
  Measuring reperfusion in the catheter laboratory
  Ian Webb and Simon Redwood
  
  Keywords: Microvascular dysfunction, primary angioplasty, reperfusion
• METABOLIC IMAGING
  Scoring reperfusion by contrast-enhanced magnetic resonance imaging
  Giuseppe Tarantini and Sabino Iliceto
  
  Keywords: Acute myocardial infarction, magnetic resonance imaging, primary angioplasty
• NEW THERAPEUTIC APPROACHES
  Postconditioning the human heart
  Hélène Thibault, Denis Angoulvant, Cyrille Bergerot and Michel Ovize
  
  Keywords: Ischemia, myocardial infarction, postconditioning, reperfusion
• FOCUS ON TRIMETAZIDINE (VASTAREL MR)
  Clinical benefi ts of a metabolic approach in the treatment of ischemic heart disease: focus on Vastarel MR
  Mario Marzilli
  
  Keywords: Angina, cardiac energy metabolism, ischemic heart disease, trimetazidine
• CASE REPORT
  Primary angioplasty: worth the trouble?
  Mrinal Saha
  
  Keywords: Acute myocardial infarction, bifurcation disease, clopidrogrel, kissing balloons, primary angioplasty
• REFRESHER CORNER
  The paradoxes of reperfusion in the ischemic heart
  Naranjan S. Dhalla and Todd A. Duhamel
  
  Keywords: Calcium-overload, cardiac dysfunction, ischemic myocardium, oxidative stress, reperfusion injury, subcellular remodeling
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Improving prognosis in ischemic heart disease: time to maximize benefit
  Graham Jackson
• BASIC ARTICLE
  The atherosclerotic plaque was not built in a day: the dynamic nature of plaque progression and instability
  Martin R. Bennett
  
  Keywords: Vascular smooth muscle cells, apoptosis, atherosclerosis, vascular, inflammation
• MAIN CLINICAL ARTICLE
  Pharmacologic prevention of coronary plaque rupture – the major cause of acute coronary syndromes
  Petri T. Kovanen and Markku O. Pentikäinen
  
  Keywords: Coronary artery disease, plaque rupture, pharmacotherapy
• METABOLIC IMAGING
  Metabolic imaging: the role of imaging in risk evaluation of ischemic heart disease
  Mark T. Harbinson
  
  Keywords: Ischemic heart disease, metabolic tracers, myocardial perfusion imaging, nuclear cardiology, prognosis
• NEW THERAPEUTIC APPROACHES
  Beyond pharmacology in heart attacks: coronary stents and stem cells
  Cheuk-Kit Wong, Neal S. Kleiman and Harvey D. White
  
  Keywords: Myocardial infarction, stem cells, stents
• The Emperor has no clothes: reading between the lines of the COURAGE report
  Mario Marzilli
  
  Keywords: Angina, coronary artery disease, ischemic syndromes, percutaneous coronary intervention, percutaneous transluminal coronary angioplasty
• FOCUS ON VASTAREL MR
  The metabolic approach to improving prognosis in ischemic heart disease
  Pericle Di Napoli
  
  Keywords: Trimetazidine, heart failure, ischemic heart disease, prognosis
• CASE REPORT
  You are never too old
  Cristiana Vitale
  
  Keywords: Compliance, elderly, prognosis, trimetazidine
• REFRESHER CORNER
  Reducing the risks in diabetes
  Giuseppe Rosano and Maria Cristina Ribaudo
  
  Keywords: Cardiovascular events, diabetes mellitus, risk, cholesterol, hypertension, exercise
• FEATURED RESEARCH
  Abstracts and Commentaries
  Gary Lopaschuk
• GLOSSARY
  Gary D. Lopaschuk

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• EDITORIAL
  Cardiac toxicity
  Danielle Feuvray
• BASIC ARTICLE
  Molecular basis of anthracycline-induced cardiotoxicity
  Richard S. Vander Heide and Thomas J. L’Ecuyer
  
  Keywords: Anthracycline, cardiotoxicity, cardiac muscle, oxidative stress, apoptosis, mechanism
• MAIN CLINICAL ARTICLE
  Mechanisms, manifestations, and management of digoxin toxicity
  Lionel G. Lelièvre and Philippe Lechat
  
  Keywords: Arrhythmias, digoxin, cardiotoxicity, human Naþ/Kþ-ATPase isoforms, ventricular tachycardia
• METABOLIC IMAGING
  Myocardial perfusion imaging and cardiac events in asymptomatic patients with diabetes
  Denis Mariano-Goulart
  
  Keywords: Diabetes mellitus, occult coronary artery disease, myocardial perfusion imaging, scintigraphy, screening
• NEW THERAPEUTIC APPROACHES
  Role of ATP-binding cassette transporters in drug distribution to the heart and protection from toxic compounds
  Lucie Couture, John. A. Nash and Jacques Turgeon
  
  Keywords: ABC transporters, cardiac drug distribution, cardiotoxicity, drug efflux, heart protection
• FOCUS ON TRIMETAZIDINE (VASTAREL MR)
  The importance of a metabolic approach to anti-ischemic protection
  Graham Jackson
  
  Keywords: Ischemia, ischemic burden, metabolic agents, trimetazidine
• CASE REPORT
  Trimetazidine and left ventricular dysfunction: patients must play their part also
  Graham Jackson
  
  Keywords: Alcohol excess, pre-diabetes, left ventricular dysfunction, lifestyle, trimetazidine
• REFRESHER CORNER
  Preventing the cardiotoxic effects of anthracyclines: from basic concepts to clinical data
  Catherine Vergely, Stéphanie Delemasure, Yves Cottin and Luc Rochette
  
  Keywords: Anthracyclines, cardiotoxicity, congestive heart failure, reactive oxygen species, ACE inhibitors
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Picture my heart!
  Michael Marber
• BASIC ARTICLE
  Coronary computed tomographic angiography: current and future uses
  Birgit Kantor, Ronald S. Kuzo and Thomas C. Gerber
  
  Keywords: Angiography, computed tomography, coronary artery disease, diagnosis
• MAIN CLINICAL ARTICLE
  Perspectives of new imaging techniques for patients with known or suspected coronary artery disease
  Joanne D. Schuijf and Jeroen J. Bax
  
  Keywords: Non invasive imaging, coronary artery disease
• METABOLIC IMAGING
  The future of positron emission tomography/computed tomography imaging of the heart
  Philipp A. Kaufmann
• NEW THERAPEUTIC APPROACHES
  Cardiac interventions guided by magnetic resonance imaging
  Titus Kuehne
  
  Keywords: Magnetic resonance imaging, intervention, congenital heart disease
• FOCUS ON VASTAREL MR
  Effi cacy of the metabolic approach in ischemic heart diseases. Non invasive assessment of myocardial perfusion, metabolism, and left ventricular function
  Romualdo Belardinelli
  
  Keywords: Metabolic modulation, chronic myocardial ischemia, trimetazidine, dobutamine stress echocardiography, SPECT imaging
• CASE REPORT
  Multislice computed tomography coronary angiography before percutaneous recanalization of chronic total occlusions
  N. R. Mollet, N. Van Pelt, G. Sianos, W.B. Meijboom, F. Cademartiri and P.J. de Feyter
  
  Keywords: Chronic total occlusion, coronary artery, multislice computed tomography, percutaneous revascularization
• REFRESHER CORNER
  Obtaining cardiac images from positron emission tomography, computed tomography, and magnetic resonance imaging: physical principles
  Ronald Boellaard
  
  Keywords: Physical principles, positron emission tomography, computed tomography, magnetic resonance imaging, cardiology, structural, functional, molecular, imaging
• FEATURED RESEARCH
  Abstracts and commentaries

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• EDITORIAL
  Arrhythmia and metabolism
  Danielle Feuvray
• BASIC ARTICLE
  Metabolic signals of arrhythmia
  Jason R.B.Dyck and Peter E. Light
  
  Keywords: Arrhythmia, cardiac energy metabolism, ion channels, AMPK, PRKAG2
• MAIN CLINICAL ARTICLE
  Metabolic gene defects and risk of arrhythmia
  Patrick T. Ellinor, David J. Milan and Calum A. MacRae
  
  Keywords: Glycogen, fatty acid, mitochondrial, atrial fibrillation, ventricular tachycardia
• METABOLIC IMAGING
  Imaging and arrhythmia
  Reza Razavi
  
  Keywords: Arrhythmia, echocardiography, computed tomography, magnetic resonance imaging
• NEW THERAPEUTIC APPROACHES
  New therapeutic approaches in atrial fi brillation
  Bas A. Schoonderwoerd and Isabelle C. Van Gelder
  
  Keywords: Atrial fibrillation, antiarrhythmic drugs, anticoagulation, radiofrequency ablation, treatment
• FOCUS ON VASTAREL MR
  Modulation of metabolic changes in patients with heart failure by selective inhibition of 3-ketoacyl coenzyme A thiolase
  Gabriele Fragasso, Altin Palloshi, Amarild Cuko and Roberto Spoladore
  
  Keywords: Trimetazidine, heart failure, left ventricular function, glucose metabolism, free fatty acids
• CASE REPORT
  Anderson-Fabry disease: an important differential diagnosis in patients with unexplained left ventricular hypertrophy
  Perry Elliott
  
  Keywords: Anderson–Fabry disease, left ventricular hypertrophy, women
• REFRESHER CORNER
  Cellular changes in atrial fi brillation
  Jolanda van der Velden, Nadiya A. Narolska and Ger J.M. Stienen
  
  Keywords: Atrial fibrillation, contractility, cardiomyocyte function, contractile proteins
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Metabolic profi le in heart disease
  Mario Marzilli
• BASIC ARTICLE
  Understanding the metabolic phenotype of heart disease
  Rong Tian
  
  Keywords: energetics, heart failure, transgenic mice, fatty acid oxidation, glucose metabolism, metabolic therapy
• MAIN CLINICAL ARTICLE
  Clinical implications of energetic problems in cardiovascular disease
  John R. Ussher and Gary D. Lopaschuk
  
  Keywords: Fatty acid oxidation, trimetazidine, glucose oxidation, energy metabolism
• METABOLIC IMAGING
  Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy
  Michiel ten Hove and Stefan Neubauer
  
  Keywords: 31P-Magnetic resonance spectroscopy, 1H-magnetic resonance spectroscopy, 13C-magnetic resonance spectroscopy, cardiac metabolism
• NEW THERAPEUTIC APPROACHES
  Metabolic profiling in heart disease
  David J. Grainger
  
  Keywords: Metabonomics, atherosclerosis, myocardial infarction, pronostics
• FOCUS ON VASTAREL MR
  Trimetazidine and the metabolic profi le of ischemia
  Graham Jackson
  
  Keywords: Heart disease, left ventricular function, myocardial metabolism, prognosis, trimetazidine
• CASE REPORT
  Altered AMP-activated protein kinase activity and pathologic cardiac disease
  Michael H. Gollob, Martin S. Green and John P. Veinot
  
  Keywords: AMP-activated protein kinase (or AMPK), Wolff–Parkinson–White, arrhythmia, glycogen storage disease, hypertrophy, genetics
• REFRESHER CORNER
  Regulation of gene expression by polyunsaturated fatty acids
  Harini Sampath and James M. Ntambi
  
  Keywords: Polyunsaturated fatty acids, SREBP1c, PPAR, LXR
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Persistent angina: the good, the bad, and the ugly
  Frans C. Visser
• BASIC ARTICLE
  Oxidative stress and ischemia
  Joël de Leiris, Andry Rakotovao and François Boucher
  
  Keywords: Oxidative stress, free radicals, myocardial ischemia, reperfusion, cellular injury
• MAIN CLINICAL ARTICLE
  Persistent angina
  Mario Marzilli, Marta Focardi, Silvia Affi nito, Eugenia Capati and Rossella Urselli
  
  Keywords: Persistent angina, percutaneous transluminal coronary angioplasty, coronary stenosis, randomised intervention treatment of angina trial, arterial revascularization therapy study
• IMAGING
  Cardiac imaging for the detection of ischemia after percutaneous coronary intervention
  Kenneth N. Giedd
  
  Keywords: Computed tomography angiography, myocardial perfusion imaging, percutaneous coronary intervention
• NEW THERAPEUTIC APPROACHES
  Exciting developments in stable angina – the rise of the f-channels
  Adrian J. B. Brady
  
  Keywords: Angina, b-blockers, heart rate, cardiac ion channels, f-channels, If current, ivabradine
• FOCUS ON VASTAREL MR
  From recurrent ischemia to ischemic heart failure: new data on trimetazidine
  Jaroslaw D. Kasprzak
  
  Keywords: Ischemic cardiomyopathy, heart failure, recurrent ischemia, trimetazidine
• CASE REPORT
  Persistent angina after myocardial revascularization: a case report
  Marta Focardi, Eugenia Capati, Silvia Affi nito, Rossella Urselli and Mario Marzilli
  
  Keywords: Persistent angina, complete myocardial revascularization, microvascular angina, stable angina, stress test ischemia
• REFRESHER CORNER
  Warm up angina
  Rainer Zbinden and Michael S. Marber
  
  Keywords: Angina, ischemic preconditioning, myocardial collaterals
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Metabolic syndrome and its management
  Gary Lopaschuk
• BASIC ARTICLE
  Lipotoxicity in cardiac and skeletal muscle
  Jennifer L. Peura and Jean E. Schaffer
  
  Keywords: Lipotoxicity, cardiomyopathy, myopathy, fatty acids, triglycerides
• MAIN CLINICAL ARTICLE
  The metabolic syndrome
  Bernhard O. Boehm and Stephan Schiekofer
  
  Keywords: Diabetes, hyperglycemia, dyslipidemia, pleiotropic effects, lifestyle modification, metabolic syndrome
• METABOLIC IMAGING
  Metabolic imaging in the metabolic syndrome
  Linda Peterson
  
  Keywords: Metabolic syndrome, metabolism, positron emission tomography, heart, magnetic resonance spectroscopy
• NEW THERAPEUTIC APPROACHES
  Metabolic syndrome: pharmacological treatment
  Pieter A. van Zwieten and Frans Visser
  
  Keywords: Metabolic syndrome, insulin resistance, antihypertensive drugs, diabetes mellitus (type 2), obesity, hyperlipidemia
• FOCUS ON VASTAREL MR
  Effect of selective 3-ketoacyl coenzyme A thiolase inhibition on glucose metabolism in cardiac patients
  Gabriele Fragasso et al.
  
  Keywords: Trimetazidine, diabetes, glucose metabolism, left ventricular function, endothelial function, 3-ketoacyl coenzyme A thiolase inhibition
• CASE REPORT
  Hypercalcemia and the cardiovascular system
  V.J. Karthikeyan et al.
  
  Keywords: Hypercalcemia, hyperparathyroidism, hypertension, heart failure, complete heart block, renal failure
• REFRESHER CORNER
  What is insulin resistance?
  Gurushankar Govindarajan et al.
  
  Keywords: Hypertension, polycystic ovary disease, cardiometabolic syndrome, diabetes mellitus, cardiovascular disease, renal disease
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Bypass surgery for coronary artery disease: a vanishing treatment?
  Frans Visser
• BASIC ARTICLE
  Mechanism of cardiac damage associated with cardiac surgery
  David J. Chambers
• MAIN CLINICAL ARTICLE
  Managing contractile dysfunction after cardiac surgery
  Armand R. Girbes and A. B. Johan Groeneveld
• METABOLIC IMAGING
  Value of perioperative transesophageal echocardiography
  Otto Kamp
• NEW THERAPEUTIC APPROACHES
  Metabolic interventions during cardiac surgery: focus on glucose–insulin–potassium
  Harry B. van Wezel
• FOCUS ON VASTAREL MR
  Protective effects of trimetazidine before and after coronary artery bypass surgery
  Álvaro D.B. Bordalo
• CASE REPORT
  Hibernating myocardium and coronary artery bypass surgery
  Ian Hunt and Tunde Ogunyiluka
• REFRESHER CORNER
  Risk associated with cardiac surgery
  Christopher Blauth
• FEATURED RESEARCH
  Abstracts and commentaries

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• EDITORIAL
  Graham Jackson
• BASIC ARTICLE
  Erectile dysfunction as an early indicator of cardiovascular and metabolic disease
  Kevin L. Billups
• MAIN CLINICAL ARTICLE
  Managing sexual dysfunction in the cardiac patient
  Adolph M. Hutter Jr
• NEW THERAPEUTIC APPROACHES
  Safety and efficacy of the medical treatment of erectile dysfunction
  Graham Jackson
• FOCUS ON VASTAREL MR
  Efficacy and safety of trimetazidine and phosphodiesterase type-5 inhibitors
  Graham Jackson
• CASE REPORT
  Erectile dysfunction as a marker of silent ischemia
  Michael Kirby
• REFRESHER CORNER
  The hemodynamics of sex
  Ian Eardley
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Metabolic approach in heart failure
  Graham Jackson
• BASIC ARTICLE
  Metabolic approach in heart failure: the rationale for metabolic interventions
  Gary D. Lopaschuk, William A. Stanley, Catharine C. Lopaschuk
• MAIN CLINICAL ARTICLE
  The place of metabolic treatment
  Hanna Szwed
• METABOLIC IMAGING
  Glucose–insulin–potassium infusion enhances myocardial wall motion in patients with chronic ischemic heart failure
  Lucas J. Klein, Linda (C.) M.C. van Campen, Thomas H. Marwick
• NEW THERAPEUTIC APPROACHES
  Evidence of efficacy of metabolic agents
  Mario Marzilli, Silvia Affinito
• FOCUS ON VASTAREL MR
  Vastarel MR: an innovative metabolic approach to ischemic heart failure
  Elena Louette
• CASE REPORT
  An elderly lady with angina and heart failure—successful response to trimetazidine
  Graham Jackson
• REFRESHER CORNER
  Metabolic link between ischemia and cardiac dysfunction
  William C. Stanley
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  Gary Lopaschuk

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• EDITORIAL
  Cardiovascular effects of exercise
  M. Marzilli
• BASIC ARTICLE
  Adaptive and maladaptive cardiac hypertrophy
  M. F. Allard
• MAIN CLINICAL ARTICLE
  Risks and benefits of exercise in cardiac disease
  N. Smart, T. H. Marwick
• METABOLIC IMAGING
  Imaging: hypertrophic cardiomyopathy and athlete’s heart
  I. Paetsch, E. Nagel
• NEW THERAPEUTIC APPROACHES
  Constructing an exercise program
  A. A. McLeod
• FOCUS ON VASTAREL MR
  New therapeutic approach in chronic heart failure: metabolic intervention with trimetazidine
  H. S. Sisakyan
• CASE REPORT
  Sustained benefit of trimetazidine adjunct to standard treatment in severe heart failure
  M. Marzilli
• REFRESHER CORNER
  Cardiac adaptation to exercise
  H. Kuipers
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  G. Lopaschuk

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• EDITORIAL
  Heart failure in diabetes
  M. Marber
• BASIC ARTICLE
  Metabolic derangements in insulin resistance
  D. Feuvray
• MAIN CLINICAL ARTICLE
  Management of chronic heart failure in patients with type 2 diabetes: the importance of an integrated approach
  V. A. Ezzat, M. T. Kearney
• METABOLIC IMAGING
  Metabolic imaging and diabetes
  J. Knuuti
• NEW THERAPEUTIC APPROACHES
  Novel approaches in the treatment of diabetes mellitus diabetic cardiomyopathy
  R. Belardinelli
• FOCUS ON VASTAREL MR
  Ischemic heart disease and diabetes: rationale for a metabolic approach, and clinical evidence
  P. Meurin, T. He´nane
• CASE REPORT
  Diabetes and heart failure
  S. Wheatcroft
• REFRESHER CORNER
  Peroxisome proliferator-activated receptors and the cardiovascular system
  L. A. Nikolaidis, T. B. Levine
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  G. Lopaschuk

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• EDITORIAL
  What’s new in angina pectoris?
  F. C. Visser
• BASIC ARTICLE
  Molecular mechanisms of cardiac ischemic pain
  F. Crea
• MAIN CLINICAL ARTICLE
  Risk stratification in chronic stable angina
  M. Marzilli
• METABOLIC IMAGING
  Imaging the coronary vasculature using multislice computed tomography
  N. R. Mollet et al
• NEW THERAPEUTIC APPROACHES
  New developments in the drug treatment of stable angina pectoris
  P. A. van Zwieten, F. C. Visser
• FOCUS ON VASTAREL MR
  Vastarel MR: effective and safe for coronary patients treated with a phosphodiesterase type 5 inhibitor
  G. Rosano
• CASE REPORT
  Neurogenic induced myocardial dysfunction
  I. A. C. van der Bilt, F. C. Visser
• REFRESHER CORNER
  Assessment of collateral circulation
  Gerald S. Werner
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  G. Lopaschuk

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• EDITORIAL
  Metabolic interventions for acute coronary syndromes?
  F. C. Visser
• BASIC ARTICLE
  Alterations in energy metabolism in acute coronary syndromes
  A. Noga, J. R. B Dyck, G. Lopaschuk
• MAIN CLINICAL ARTICLE
  Risk stratification and outcome in non-ST-segment elevation in acute coronary syndromes R. Malhotra and M. S. Sabatine
• METABOLIC IMAGING
  Glucose and fatty acid changes in acute coronary syndromes
  A-S. E. Hamby¨e, P. R. Franken
• NEW THERAPEUTIC APPROACHES
  Guidelines and metabolic approach to acute coronary syndrome
  F. R. Eberli
• FOCUS ON VASTAREL MR
  Metabolic cardioprotection in patients undergoing revascularization
  P. Meurin and T. He´nane
• CASE REPORT
  Beneficial role of metabolic treatment in a patient with refractory angina after an
  acute coronary syndrome
  H. Szwed
• REFRESHER CORNER
  Metabolic changes in ischemia and myocardial infarction
  W. C. Stanley
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY
  G. Lopaschuk

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• EDITORIAL
  Endothelial dysfunction
  G. Jackson
• BASIC ARTICLE
  Endothelial function and dysfunction
  P. Vanhoutte
• MAIN CLINICAL ARTICLE
  Clinical expression of endothelial dysfunction
  W. Dunn, A. Lerman, V. Shah
• METABOLIC IMAGING
  Imaging of coronary endothelial dysfunction by use of positron emission tomography
  F. M. Bengel
• NEW THERAPEUTIC APPROACHES
  Treatment options for endothelial dysfunction
  S. von Haehling
• FOCUS ON VASTAREL MR
  Evidence-based efficacy of Vastarel in patients with ischemic cardiomyopathy
  H. C. Tan
• CASE REPORT
  Imaging of endothelial dysfunction
  P. Knaapen, W. G. van Dockum
• REFRESHER CORNER
  Regulation of coronary perfusion
  S. J. Fraser, D. E. Newby, N. G. Uren
• FEATURED RESEARCH
  Abstracts and commentaries
• GLOSSARY