Number 70, 2016, Reducing myocardial infarct size: myth or reality

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  • EDITORIAL
    Burning fat to increase metabolic rates size: myth or reality
    Derek J. Hausenloy, MD, PhD, FACC, FESC
    Read the editorial
  • ORIGINAL ARTICLES
    Reperfusion – the good, the bad, and the ugly
    Gerd Heusch, FACC, FESC, FRCP
    Institute for Pathophysiology, West German Heart and Vascular Center,
    University of Essen Medical School, Essen, Germany
    Keywords: cardioprotection, myocardial ischemia, reperfusion
  • ORIGINAL ARTICLES
    Mechanical interventions to reduce myocardial infarct size
    Michael Rahbek Schmidt, MD, PhD; Nichlas Riise Jespersen, MD; Hans Erik Bøtker, MD, PhD, DMSc
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
    Keywords: ischemic preconditioning, myocardial infarction, reperfusion injury
  • ORIGINAL ARTICLES
    How to measure myocardial infarct size by cardiac magnetic resonance imaging
    David Corcoran, BMedSci MRCP; Colin Berry, PhD, FACC, FESC, FRCP
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow
    Golden Jubilee National Hospital, Clydebank, UK
    Keywords: acute myocardial infarction, CMR imaging, infarct size
  • ORIGINAL ARTICLES
    Pharmacological agents for reducing myocardial infarct size in ST-segment elevation myocardial infarction
    Thomas Bochaton, MD; François Derimay, MD; Michel Ovize, MD, PhD
    Louis Pradel Hospital, Cardiovascular Functional Exploration Service,
    Clinical Investigation Center & UMR1060 (CarMeN), Claude Bernard University Lyon 1, Lyon, France
    Keywords: ischemia-reperfusion, ST-segment elevation myocardial infarction, treatment of reperfusion injury
  • ORIGINAL ARTICLES
    The cardioprotective effects of trimetazidine
    Petr Widimsky, MD, DrSc, FESC, FACC
    Cardiocenter, Third Faculty of Medicine, Charles University Prague, Czech Republic
    Keywords: angina, cardioprotection; trimetazidine
  • CASE REPORT
    Assessing myocardial salvage in reperfused STEMI patients by hybrid cardiac PET-MR imaging
    Heerajnarain Bulluck, MBBS, MRCP
    The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK;
    The National Institute of Health Research University College London Hospitals Biomedical Research Center, UK
    Keywords: myocardial salvage, PET-MR, ST-segment elevation myocardial infarction
  • REFRESHER CORNER
    Metabolic changes in the acutely ischemic heart
    Gary D. Lopaschuk, PhD
    Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Keywords: glycolysis; ischemia, reperfusion
    glycolysis; ischemia, reperfusion
  • HOT TOPICS
    Reducing myocardial infarct size by remote ischemic conditioning
    Luciano Candilio, MD(Res)
    The Hatter Cardiovascular Institute, University College London, London, UK
    Keywords: cardioprotection, myocardial infarction, remote ischemic conditioning
  • GLOSSARY
    Gary D. Lopaschuk

Number 69, 2016, Good fat or bad fat?

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  • EDITORIAL
    Burning fat to increase metabolic rates
    G. D. Lopaschuk
    Read the editorial
  • ORIGINAL ARTICLES
    Brown adipose tissue and the genetics of obesity
    Ande Satyanarayana, PhD
    Department of Biochemistry and Molecular Biology, Molecular Oncology & Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia, USA
    Keywords: beige cells, brown fat, genetic mouse models, oxidative metabolism, PGC1α, thermogenesis; UCP1
  • ORIGINAL ARTICLES
    Integrated control of brown adipose tissue
    Emanuele Marzetti, MD, PhD1; Emanuela D’Angelo, MD1; Giulia Savera, BS1; Christiaan Leeuwenburgh, PhD2; Riccardo Calvani, PhD1
    1Department of Geriatrics, Neurosciences and Orthopedics, Teaching Hospital “Agostino Gemelli,” Rome, Italy 2Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, USA
    Keywords: adiposity, beige cells, diabetes mellitus, energy metabolism, inflammation, mitochondrial respiration, positron emission tomography (PET), sympathomimetics, weight loss
  • ORIGINAL ARTICLES
    Assessing brown adipose tissue in humans
    Yu-Shin Ding, PhD New York University School of Medicine, Departments of Radiology and Psychiatry, New York, NY, USA
    Keywords: brown adipose tissue, [11C]MRB, obesity, norepinephrine transporter, positron emission tomography (PET), sympathetic nervous system
  • ORIGINAL ARTICLES
    Brown adipose tissue as a potential therapeutic target in obesity therapy
    Niels Jessen, MD, PhD Research Laboratory for Biochemical Pathology, Department for Clinical Medicine, Aarhus University, Denmark
    Keywords: activators of thermogenesis, brown adipose tissue, obesity
  • ORIGINAL ARTICLES
    Benefits of trimetazidine (TMZ) in obese patients
    Fausto J. Pinto, FESC, FACC Lisbon University Medical School, University of Lisbon, Lisbon, Portugal
    Keywords: ischemic heart disease, obesity; trimetazidine
  • CASE REPORT
    Obesity and cardiovascular disease
    Giacinta Guarini, MD, PhD Cardiovascular Medicine Division, Cardio Thoracic and Vascular Department, University of Pisa, Italy
    Keywords: heart failure, obesity cardiomyopathy, obesity paradox
  • REFRESHER CORNER
    Uncoupling proteins as mediators of mitochondrial metabolic rates
    Gary D. Lopaschuk, PhD Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    Keywords: mitochondria, mitochondrial membrane potential, thermogenesis, uncoupling protein 1, uncoupling protein 3
  • HOT TOPICS
    Will PCSK9 inhibitors stand up to statins till the end?
    Alda Huqi, MD, PhD
  • GLOSSARY
    G. D. Lopaschuk

Number 68, 2015, Diabetes: is it enough to control blood glucose?

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  • EDITORIAL
    Cardiovascular events in diabetics: a great challenge and an unsolved problem
    M. Marzilli
    Read the editorial
  • ORIGINAL ARTICLES
    Diabetes and ischemia: similarities in cardiac energy metabolism
    Tariq R. Altamimi, BSc and Gary D. Lopaschuk, PhD Cardiovascular Translational Science Institute and Department of Pediatrics, University of Alberta, Edmonton, Canada
    Keywords: cardiac efficiency; diabetes; energy metabolism; heart; ischemia
  • ORIGINAL ARTICLES
    Stents, surgery, and optimal medical therapy in diabetes
    Sonya N. Burgess, BSc, MBChB, FRACP; John K. French, BMedSc, MBChB, MSc, PhD Department of Cardiology, Liverpool Hospital and SWS Clinical School, The University of New South Wales, Sydney, NSW, Australia
    Keywords: coronary artery bypass graft surgery, coronary heart disease, diabetes mellitus, optimal medical therapy, percutaneous coronary intervention
  • ORIGINAL ARTICLES
    Strain, perfusion, and fat in the diabetic heart
    Grigorios Korosoglou1, Prof. Dr. med. and Hugo A. Katus2, Prof. Dr. med. 1GRN Hospital Weinheim, Weinheim, Germany 2Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Keywords: cardiac magnetic resonance, diabetes mellitus, diastolic dysfunction, echocardiography, late gadolinium enhancement, metabolism, myocardial perfusion, spectroscopy
  • ORIGINAL ARTICLES
    Is glycemic control relevant to cardiovascular clinical outcomes?
    Angelo Avogaro, MD, PhD Department of Medicine, University of Padova, Padova, Italy
    Keywords: cardiovascular disease, diabetes mellitus, microvascular complications, risk factors
  • ORIGINAL ARTICLES
    Trimetazidine effects on preventing cardiovascular events in diabetic patients
    Luis Henrique Wolff Gowdak, MD, PhD, FESC Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
    Keywords: diabetes; metabolism; myocardial ischemia; prognosis; trimetazidine
  • CASE REPORT
    Preventing cardiovascular events in diabetic patients: the case of the patient with poor distal coronary targets
    Elisabetta Salutini, MD; Cristina Bianchi, MD; Roberto Miccoli, MD; Stefano Del Prato, MD, PhD Department of Clinical and Experimental Medicine, Section of Diabetes and Metabolic Diseases, University of Pisa, Italy
    Keywords: coronary artery disease, diabetes, glucagon-like peptide-1 agonists, hypoglycemia, incretin, microvascular coronary dysfunction
  • REFRESHER CORNER
    Diabetic cardiomyopathy, does it exist?
    Heiko Bugger, MD, PhD Heart Center Freiburg University, Freiburg, Germany
    Keywords: diabetic cardiomyopathy, diabetes mellitus, heart
  • HOT TOPICS
    Antidiabetic treatment and cardiovascular events: all a matter of perspective!
    Alda Huqi, MD
    GLOSSARY
    G. D. Lopaschuk

Number 67, 2015, Troponin in ACS

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  • EDITORIAL
    The sensitivity versus specificity trade-off
    Michael Marber, PhD, FRCP
    Read the editorial
    ORIGINAL ARTICLES
    Using biomarkers to obtain mechanistic insight and guide management in acute coronary syndrome
    Kai C. Wollert, MD
    Keywords: acute coronary syndrome, acute myocardial infarction, biomarker, cardiac troponin, diagnosis, patient management, prognosis

    ORIGINAL ARTICLES
    Incorporating high-sensitivity cardiac troponin assays into clinical practice: these assays are your friend
    Sara Love, PhD, Yader Sandoval, MD, Fred S. Apple, PhD
    Keywords: biomarkers, cardiac troponin, diagnostic accuracy, high-sensitivity assays, myocardial infarction, outcomes

    ORIGINAL ARTICLES
    High biomarkers, but normal angiogram: what next?
    Sebastiaan C. A. M. Bekkers, MD, PhD, Martijn W. Smulders, MD
    Keywords: acute myocardial infarction, angiography, cardiovascular magnetic resonance imaging, computed tomography, nonobstructed coronary arteries, normal coronary arteries

    ORIGINAL ARTICLES
    What can we learn from metabolomics?
    Ferheen Baig, MSc, BSc, Manuel Mayr, MD, PhD
    Keywords: biomarker, cardiovascular, diabetes, lipidomics, metabolomics

    ORIGINAL ARTICLES
    Trimetazidine effects on cardiac biomarkers in acute coronary syndrome
    Dr Jamshed Jal Dalal, MD, PhD
    Keywords: acute coronary syndrome, cardiac biomarker, metabolic management, trimetazidine

    CASE REPORT
    Elevated cardiac troponin in a patient with coronary artery disease: why look harder?
    Annette Maznyczka, BSc, MBChB, MRCP, Niharika Varma, BSc, MBBS, Lucy Foote, MBBS, Rupert Williams,
    BSc, MBChB, MRCP, David D’Cruz, MD, FRCP, Valentina O. Puntmann, MD, PhD, MRCP
    Keywords: chest pain, magnetic resonance imaging, systemic lupus erythematosus, troponin

    REFRESHER CORNER
    Defining acute myocardial infarction
    Kai M. Eggers, MD, PhD
    Keywords: definition criteria, diagnosis, myocardial infarction, troponin

    HOT TOPICS
    Metabolic markers in predicting acute cardiovascular events
    Alda Huqi, MD
    GLOSSARY
    G. D. Lopaschuk

Number 66, 2015, Hormones and the heart

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  • EDITORIAL
    Hormones and the heart
    G. Jackson
    Read the editorial
  • ORIGINAL ARTICLES
    Thyroid, aldosterone, and cardiovascular disease
    C. Vlachopoulos, D. Terentes-Printzios
    Keywords: aldosterone, cardiovascular disease, heart failure, hormone, thyroid
  • ORIGINAL ARTICLES
    Testosterone and cardiovascular disease
    T. Hugh Jones
    Keywords: cardiovascular, diabetes, heart, testosterone
  • ORIGINAL ARTICLES
    Measuring myocardial salvage: hormone cardioprotection
    D. J. Hausenloy
    Keywords: acute myocardial infarction, cardiac MRI, cardioprotection, myocardial reperfusion injury, myocardial salvage, PET/MRI
  • ORIGINAL ARTICLES
    Testosterone and the heart
    C. C. K. Ho, H. M. Tan
    Keywords: cardiovascular, metabolic syndrome, testosterone
  • ORIGINAL ARTICLES
    Effects of trimetazidine on hormones and the heart
    V. Sansoy, K. Kılıçkesmez
    Keywords: angina pectoris, cardiac metabolism, coronary artery disease, heart failure, natriuretic peptides
  • CASE REPORT
    Erectile dysfunction and lower urinary tract symptoms should trigger a metabolic
    screen and cardiovascular risk estimation
    M. Kirby
    Keywords: cardiovascular disease, erectile dysfunction, lower urinary tract symptoms, metabolic syndrome, lifestyle
  • REFRESHER CORNER
    Evaluation of metabolic syndrome and male sexual dysfunction
    J. J. Heidelbaugh, M. M. Miner
    Keywords: cardiometabolic risk, erectile dysfunction, male sexual dysfunction, metabolic syndrome
  • HOT TOPICS
    Testosterone replacement therapy: cardiovascular benefits and possible risks
    G. Hackett
    Keywords: cardiovascular disease, elderly, European Male Ageing Study, hypogonadism, men, testosterone, testosterone deficiency syndrome
  • GLOSSARY
    G. D. Lopaschuk

Number 65, 2014, MicroRNAs

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  • EDITORIAL
    The rapid emergence of microRNAs as a therapeutic target to treat cardiovascular disease
    G. D. Lopaschuk
    Read the editorial
  • ORIGINAL ARTICLES
    MicroRNA therapeutics for cardiovascular disease
    E. van Rooij
    Keywords: anti-miR, cardiovascular disease, microRNA; miRNA mimic, therapeutics
  • ORIGINAL ARTICLES
    Targeting microRNAs to promote cardiac repair and cardiomyocyte proliferation as a potential regenerative therapeutic approach
    P. Jakob, U. Landmesser
    Keywords: dyspnea; exercise, heart failure, skeletal musculature
  • ORIGINAL ARTICLES
    Evaluation of microRNAs by molecular imaging for novel diagnostics and therapeutics
    W. Kloos, A. Keller, H. A. Katus, B. Meder
    Keywords: biomarker, cardiovascular disease, microRNA, molecular imaging, therapeutic target
  • ORIGINAL ARTICLES
    The therapeutic potential of microRNAs in heart and vascular diseases
    A. Zampetaki, B. Fanshawe, M. Mayr
    Keywords: cardiovascular disease, microRNA, therapeutic application
  • ORIGINAL ARTICLES
    Nonmetabolic effects of trimetazidine and ventricular remodeling: role in regulatory gene expression
    P. Di Napoli
    Keywords: heart failure, mRNA, remodeling, trimetazidine
  • CLINICAL APPLICATION
    MicroRNA therapy of heart failure
    L. R. Rodino-Klapac
    Keywords: antagomiRs, biomarkers, heart failure, microRNAs, miR mimics
  • REFRESHER CORNER
    What are microRNAs?
    T. Thum
    Keywords: cardiac remodeling, cardiovascular disease, heart failure, microRNA
  • HOT TOPICS
    MicroRNAs as therapeutics for heart disease
    J. R. Ussher
    Keywords: cardiovascular disease, heart, heart failure, ischemic heart disease, microRNA, pulmonary arterial hypertension
  • GLOSSARY
    G. D. Lopaschuk

Number 64, 2014, Heart failure: a cardiac or a systemic disease?

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  • EDITORIAL
    Heart failure: a cardiac or a systemic disease?
    M. Marzilli
    Read the editorial
  • ORIGINAL ARTICLES
    Heart and muscle, cut from the same striated cloth
    S. von Haehling
    Keywords: Heart failure, skeletal muscle, wasting, cachexia
  • ORIGINAL ARTICLES
    The symptoms of heart failure
    M. Marzilli
    Keywords: Dyspnea, exercise, heart failure, skeletal musculature
  • ORIGINAL ARTICLES
    Imaging of skeletal muscle metabolism in heart failure
    P. Iozzo
    Keywords: Exercise, oxidative metabolism, insulin resistance, positron emission tomography, magnetic resonance imaging, muscle composition
  • ORIGINAL ARTICLES
    Benefits of exercise training for the failing heart
    R. Belardinelli
    Keywords: Exercise training, chronic heart failure, outcome
  • ORIGINAL ARTICLES
    Effects on global metabolism by regulation of substrate utilization in heart failure
    F. Loiacono, C. Silipigni, M. Pagnesi, G. Fragasso
    Keywords: heart failure, trimetazidine, left ventricular function, global metabolism, diabetes
  • CASE REPORT
    Skeletal muscle myopathy in advanced heart failure: a case report
    F. L. Dini, M. C. Scali, A. Simioniuc
    Keywords: Heart Failure, Echocardiography, Cardiopulmonary Exercise Test, Skeletal Muscle myopathy, Cardiac Output
  • REFRESHER CORNER
    How to interpret cardiopulmonary exercise tests
    M. Guazzi
    Keywords: cardiopulmonary exercise, oxygen consumption, ventilation inefficiency
  • HOT TOPICS
    The “skeletal muscle—fat” interplay in heart failure
    A. Huqi
    Keywords: heart failure, obesity, skeletal muscle, obesity paradox
  • GLOSSARY
    Gary D. Lopaschuk

Number 63, 2014, Diet and the heart

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  • EDITORIAL
    EAT your heart out!
    Michael Marber
    Read the editorial
  • ORIGINAL ARTICLES
    Nutrient signaling and cardiovascular aging
    Anna Planavila, Francesc Villarroya, Manlio Vinciguerra
    Keywords: Aging, cardiac hypertrophy, cardiomyocytes, cardiomyopathy, cell signaling, growth factors, heart, laminin, mice models, nutrients
  • ORIGINAL ARTICLES
    Does diet alter cardiovascular risk?
    Ramon Estruch, Gemma Chiva-Blanch
    Keywords: Atherosclerosis, cardiovascular disease, cardiovascular risk, diet, infl ammation, Mediterranean diet, olive oil, polyphenols, salt, vegetables, wine
  • ORIGINAL ARTICLES
    Epicardial adipose tissue: a simple marker of obesity or a complex mediator of cardiovascular disease?
    Ronak Rajani
    Keywords: Atherosclerosis, cardiovascular disease, epicardial adipose tissue, pathophysiology
  • ORIGINAL ARTICLES
    Gut microbes and cardiometabolic risk
    Max Nieuwdorp
    Keywords: Cardiovascular disease, gut microbiota, insulin resistance, obesity
  • ORIGINAL ARTICLES
    Focus on trimetazidine: effects on diet and the heart
    Roberto Ferrari
    Keywords: Adenosine triphosphate, angina, ATP, ATP/O2, β-oxidation, cardiac metabolism, fatty acid oxidation, ischemia, trimetazidine
  • CASE REPORT
    Resolution of metabolic syndrome after bariatric surgery: a case report
    Rahul K. Mukherjee
    Keywords: Angina, breathlessness, diet, gastric bypass, metabolic syndrome, obesity
  • REFRESHER CORNER
    Basic food composition: is it just sugar and fat?
    Thomas A. B. Sanders
    Keywords: Blood pressure, cardiovascular risk, fat, salt, sugar
  • HOT TOPICS
    The effects of bariatric surgery on the heart
    Oliver J. Rider
  • GLOSSARY
    Gary D. Lopaschuk

Number 62, 2014, Myocarditis

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  • EDITORIAL
    Myocarditis
    Graham Jackson
    Read the editorial
  • BASIC ARTICLE
    Myocarditis: the causes
    Uwe Külh
    Keywords: Autoimmunity, heart failure, inflammatory cardiomyopathy, myocarditis virus
  • MAIN CLINICAL ARTICLE
    Management of myocarditis
    Chantal El Amm, Leslie T. Cooper
    Keywords: Endomiocardial biopsy, heart failure, myocarditis
  • METABOLIC IMAGING
    Differentiating infarction from myocarditis
    Eduardo Pozo, Javier Sanz
    Keywords: Cardiac imaging techniques, cardiac magnetic resonance, differential diagnosis, myocardial infarction, myocarditis
  • NEW THERAPEUTIC APPROACHES
    Immunosuppresive therapy in virus-netagive inflammatory cardiomyopathy
    Andrea Frustaci, Cristina Chimenti
    Keywords: Heart failure, immunosuppressive therapy, myocarditis, recovery and function, viruses
  • FOCUS ON
    Metabolic remodeling as a target preventing myocardial dysfunction: focus on trimetazidine
    Alexander N. Parkhomenko, Olga Gurjeva
    Keywords: Cardiomyopathy, ischemia, metabolic remodeling, reperfusion, trimetazidine
  • CASE REPORT
    Multimodality imaging of Churg-Strauss myocarditis
    Amit Sud, Roberta L. Brum, Kelly Victor, Panagiotis Koudounis, Gerald S. Carr-Vhite, Ronak Rajani
    Keywords: Cardiac magnetic resonance, Churg-Strauss syndrome, echocardiography, eosinophilic granulomatosis polyangiitis, myocarditis
  • REFRESHER CORNER
    Myocarditis: inflammatory and endocrine causes
    Alida L.P. Caforio
    Keywords: Autoimmunity, diagnosis, dilated cardiomyopathy, endomyocardial biopsy, myocarditis
  • HOT TOPICS
    Takotsubo cardiomyopathy: a possible metabolic disorder
    Mehmood Zeb, Bushra Naheed, Fahd Irshad, Tim Edwards, Ibrahim M. Ali, Fraser Witherow
    Keywords: Takotsubo cardiomyopathy, transient LV apical ballooning, neurogenic stunned myocardium, ampulla cardiomyopathy, stress induced cardiomyopathy, broken heart syndrome, acute catecholamine cardiomyopathy
  • GLOSSARY
    Gary D. Lopaschuk

Number 61, 2013, Heart failure and metabolic disease

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  • EDITORIAL
    The metabolic contribution to heart failure
    Gary D. Lopaschuk
    Read the editorial
  • ORIGINAL ARTICLES
    The metabolic basis for the obesity paradox in heart failure
    Stephan von Haehling
    Keywords: Heart failure, muscle, obesity, obesity paradox
  • ORIGINAL ARTICLES
    Is chronic heart failure a reversible metabolic syndrome?
    J. Eduardo Rame
    Keywords: Cachexia, cardiac metabolism, chronic heart failure, insulin resistance
  • ORIGINAL ARTICLES
    Imaging metabolism and perfusion in patients with diabetes and heart failure
    Patricia Iozzo, Maria Angela Guzzardi
    Keywords: Cardiac fat, intervention, fatty acid oxidation, magnetic resonance spectroscopy, myocardial insulin resistance, positron emission tomography
  • ORIGINAL ARTICLES
    Inhibition of fatty acid oxidation as an approach to treat diastolic heart failure
    John R. Ussher, Jagdip S. Jaswal
    Keywords: Cardiac energetics, diastolic heart failure, diastolic dysfunction, fatty acid oxidation
  • ORIGINAL ARTICLES
    Use of trimetazidine to treat diabetes patients with heart failure
    Rui Yan, Dengfeng Gao
    Keywords: Energy metabolism, heart failure, trimetazidine
  • CASE REPORT
    Dramatic loss of weight in an obese patient with heart failure:
    a mighty heart in a big man
    Vitantonio Di Bello, Lorenzo Conte, Iacopo Fabiani, Valentina Barletta, Letizia Pieruzzi,
    Giovanna Scartabelli, Ferruccio Santini
    Keywords: Echocardiography, heart failure, natriuretic peptides, obesity
  • REFRESHER CORNER
    Energy metabolic changes in the diabetic heart
    Lionel H. Opie
    Keywords: Fatty acid oxidation, hyperglycemia, insulin resistance, metabolic syndrome
  • HOT TOPICS
    Irisin, a novel myokine: potential role in obesity and diabetes
    Andrew G. Swick
    Keywords: Brown adipose tissue,energy expenditure,irisin,myokine
  • GLOSSARY
    Gary D. Lopaschuk

Number 60, 2013, Inflame my plaque (inflammation and atherosclerosis)

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  • EDITORIAL
    Inflammation in atherosclerosis: casualty or causality?
    M. Marber
    Read the editorial
  • ORIGINAL ARTICLES
    Macrophages: cause or cure in atherosclerosis?
    M. Bennett
    Keywords: Apoptosis, atherosclerosis, inflammation, macrophages
  • ORIGINAL ARTICLES
    The role of inflammation in atherosclerosis:
    what we have learned from clinical trials?
    M. Al-Hawwas, J.-F. Tanguay
    Keywords: Atherosclerosis, coronary artery disease, inflammation
  • ORIGINAL ARTICLES
    Metabolic imaging: imaging plaques
    F. R. Joshi, M. Chowdhury, J. H. F. Rudd
    Keywords: Atherosclerosis, fluorodeoxyglucose, inflammation, non invasive imaging
  • ORIGINAL ARTICLES
    Secretory phospholipase: a potential target for cardiovascular therapies
    S. J. Nicholls, M. Duong
    Keywords: Cardiovascular disease, inflammation, risk factor, sPLA2
  • ORIGINAL ARTICLES
    Trimetazidine effects on oxidative damage
    S. J. Hong
    Keywords: Myocardial infarction, oxidative damage, trimetazidine
  • CASE REPORT
    Psoriasis and risk of cardiovascular disease: case report and discussion
    C. Maybury, C. H. Smith
    Keywords: Psoriasis, inflammation, skin disease, cardiovascular disease, anti-TNF therapy
  • REFRESHER CORNER
    Innate immunity: an integrated overview
    S. G. Shaw
    Keywords: C-type lectin receptors, innate immunity, NOD-like receptors, RIG-1-like receptors, Toll-like receptors
  • HOT TOPICS
    Can infective agents be respectable etiopathogenetic factors for acute coronary syndromes?
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 59, 2013, Where is the resistance?

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  • EDITORIAL
    Where is the resistance?
    M. Marzilli
    Read the editorial
  • BASIC ARTICLE
    Pressure drops along coronary vasculature
    G. Guarini and M. Marzilli
    Keywords: Coronary microvasculature, coronary resistance, coronary stenosis, perfusion pressure
  • MAIN CLINICAL ARTICLE
    Integrated control of coronary microvascular tone: in series mechanisms for a differential regulation of flow and capillary pressure
    G. Sambuceti, S. Capitanio and C. Marini
    Keywords: Atherosclerosis, coronary blood flow, coronary microcirculation, endothelium, 1-25-dihydroxyvitamin D, parathyroid hormone
  • METABOLIC IMAGING
    Magnetic resonance imaging perfusion to assess transmural flow distribution
    A. Chiribiri and E. Nagel
    Keywords: Adenosine, coronary disease, fractional flow reserve, high-resolution quantification, magnetic resonance imaging, perfusion
  • NEW THERAPEUTIC APPROACHES
    Do we need to lower coronary resistances?
    B. I. Lévy
    Keywords: Coronary reserve, coronary flow, capillary density, hemorheology, myocardial perfusion, pharmacology, vasodilatation
  • FOCUS ON TRIMETAZIDINE (VASTAREL® MR)
    Trimetazidine effects on restoring endothelial function
    K.-H. Park
    Keywords: Endothelium, nitric oxide, oxidative stress, trimetazidine
  • CASE REPORT
    “Resistance in the cath lab”: the utility of hyperemic stenosis resistance in the functional assessment of coronary artery disease
    K. De Silva and D. Perera
    Keywords: Fractional flow reserve, functional assessment, hyperemic stenosis resistance, microvascular resistance
  • REFRESHER CORNER
    Impact of myocardial function on perfusion
    G. Guarini
    Keywords: Coronary autoregulation, coronary metabolic dilation, coronary microcirculation, myocardial function, myocardial perfusion
  • HOT TOPICS
    Coronary arterial system: pathophysiological hints from large clinical trials
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 58, 2013, Coronary revascularization

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  • EDITORIAL
    Re-evaluating revascularization
    M. Marber
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  • BASIC ARTICLE
    Coronary flow and physiology beyond the stenosis
    M. Siebes
    Keywords: Control of coronary blood flow, coronary artery stenosis, coronary microcirculation, myocardial perfusion
  • MAIN CLINICAL ARTICLE
    Does revascularization work?
    M. S. Sidhu and W. E. Boden
    Keywords: Coronary artery disease, myocardial revascularization, optimal medical therapy, stable ischemic heart disease
  • METABOLIC IMAGING
    Imaging myocardial edema
    D. P. O’Regan and S. A. Cook
    Keywords: Acute myocardial infarction, cardiovascular magnetic resonance, myocardial salvage
  • NEW THERAPEUTIC APPROACHES
    Angiogenic therapy: is it still viable?
    C. Seiler
    Keywords: Angiogenesis, arteriogenesis, collateral circulation, coronary circulation
  • FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
    Metabolic cardiac protection is beneficial in patients undergoing coronary revascularization: is it necessary afterwards?
    Y. Lopatin
    Keywords: coronary artery bypass grafting (CABG), metabolic cardioprotection, percutaneous coronary intervention (PCI), trimetazidine
  • CASE REPORT
    Coronary artery disease: two sides of the same coin
    P. Capozza and G. Todiere
    Keywords: Acute coronary syndrome, coronary angiography, fractional flow reserve
  • REFRESHER CORNER
    History of coronary revascularization
    S. B. King
    Keywords: Coronary angioplasty, coronary artery bypass graft surgery, percutaneous coronary intervention, revascularization stenting
  • HOT TOPICS
    Revascularization and optimal medical therapy: shattering new evidence
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 57, 2012, Diastolic heart failure

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  • EDITORIAL
    The challenge of treating diastolic heart failure
    G. D. Lopaschuk
  • BASIC ARTICLE
    Differentiating diastolic dysfunction from classic heart failure
    J. S. Jaswal and J. R. Ussher
    Keywords: Cardiac energetics, diabetic cardiomyopathy, diastolic dysfunction, heart failure, obesity
  • MAIN CLINICAL ARTICLE
    Advances in the treatment of heart failure with preserved systolic function
    K. J. Lyons and J. A. Ezekowitz
    Keywords: Diastolic, drug therapy, heart failure, randomized controlled trials as topic
  • METABOLIC IMAGING
    Diastolic dysfunction: improved understanding using emerging imaging techniques
    F. L. Dini
    Keywords: Diastolic function, left ventricular filling pressure, tissue Doppler imaging, strain analysis
  • NEW THERAPEUTIC APPROACHES
    Metabolic therapy for heart failure including diastolic heart failure
    N. Siddiqi, D. Dawson, A. Rudd and M. Frenneaux
    Keywords: Cardiac energetics, cardiac metabolism, cardiomyopathy, heart failure, metabolic therapy
  • FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
    New pharmacological targets in the treatment of heart failure:
    inhibition of free fatty oxidation by trimetazidine
    N. Signoretta, L. Alberti, L. Lauretta, B. Demarchi, F. Loiacono, A. Margonato and G. Fragasso
    Keywords: Carnitine palmitoyl transferase I, free fatty acid inhibitors, heart failure, left ventricular function, metabolic therapy, myocardial metabolism, trimetazidine
  • CASE REPORT
    Acute shortness of breath and chest tightness in an elderly patient:
    clinical history tells it best!
    A. Huqi
    Keywords: Comorbidities, comprehensive evaluation, diastolic dysfunction, diastolic heart failure, non invasive assessment
  • REFRESHER CORNER
    How the heart relaxes
    N. Fillmore and G. D. Lopaschuk
    Keywords: Calcium; diastole, sarcomere, sarcoplasmic reticulum
  • HOT TOPICS
    The undisputed principles of myocardial ischemia!
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 56, 2012, The athlete’s heart

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  • EDITORIAL
    The heart of an athlete
    G. Jackson
  • BASIC ARTICE
    Physiological versus pathological left ventricular hypertrophy
    T. Kotecha, K. Fox
    Keywords: left ventricular hypertrophy, hypertrophic cardiomyopathy, athlete’s heart, echocardiography
  • MAIN CLINICAL ARTICLE
    Clinical evaluation of the athlete
    A. Cox, S. Sharma
    Keywords: arrhythmias, athlete’s heart, clinical evaluation, physiological adaptations, sudden cardiac death
  • METABOLIC IMAGING
    Athlete’s heart or hypertrophic cardiomyopathy
    R.H. Fagard
    Keywords: athlete’s heart, hypertrophic cardiomyopathy, echocardiography, endurance training, static training
  • NEW THERAPEUTIC APPROACHES
    To train or not to train? That is the question
    A.L. Baggish
    Keywords: athlete’s heart, cardiomyopathy, exercise physiology, overuse injury
  • FOCUS ON TRIMETAZIDINE (Vastarel® MR)
    The improvement of trimetazidine on exercise performance in ischemic
    heart disease
    Y. Chen
    Keywords: trimetazidine (TMZ), ischemic heart disease (IHD), exercise capacity, exercise performance;quality of life (QOL), left ventricular ejection fraction (LVEF)
  • CASE REPORT
    Life saving pre-participation athletic screening
    M. Elmaghawry, A. Zorzi, M. Perazzolo Marra, D. Corrado
    Keywords: arrhythmogenic right ventricular cardiomyopathy, electrocardiogram, pre-participation screening, implantable cardioverter defibrillator, sports cardiology
  • REFRESHER CORNER
    Effects of performance-enhancing drugs on cardiac structure
    and energy metabolism
    J.R. Ussher, J.S. Jaswal
    Keywords: performance-enhancing drugs, anabolic androgenic steroids, human growth hormone, left ventricular hypertrophy, cardiac energy metabolism
  • HOT TOPICS
    Clinical assessment of revascularized patients
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 55, 2012, Introduction to the ‘omics

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  • EDITORIAL
    Talking ‘omics
    M. Marber
  • BASIC ARTICLE
    Proteomics and microRNA profiling in cardiac fibrosis
    J. Barallobre-Barreiro, A. Didangelos, M. Mayr
    Keywords: cardiac fibrosis, fibroblasts, proteomics, miRNAs
  • MAIN CLINICAL ARTICLE
    Metabolomics in coronary heart disease
    D. J. Grainger, D. E. Mosedale
    Keywords: diagnostics, atherosclerosis, profiling, multivariate statistics
  • METABOLIC IMAGING
    Dynamic nuclear polarization and MRI for the study of cardiac metabolism
    T. R. Eykyn, R. Southworth, S. Kozerke
    Keywords: dynamic nuclear polarization, MRI, cardiac metabolism, 13C
  • NEW THERAPEUTIC APPROACHES
    Genomic prediction of individual drug response
    L. Mestroni
    Keywords: pharmacogenomics, genetic variation, cardiovascular genetics, drug response, heart failure
  • FOCUS ON TRIMETAZIDINE (Vastarel® MR)
    Efficacy of trimetazidine: lessons from meta-analyses
    J. P. Ribeiro
    Keywords: coronary artery disease, angina, heart failure, left ventricular function, functional capacity
  • CASE REPORT
    Assay what? The troponin masqueraders—a case report
    J. O. Baker, K. De Silva
    Keywords: acute myocardial infarction, cardiac troponin, assay interference, heterophile antibodies, delta change
  • REFRESHER CORNER
    Fundamentals of genome-wide association studies
    M. Mangino
    Keywords: genome-wide association, complex disease, single nucleotide polymorphisms (SNP), linkage disequilibrium
  • HOT TOPICS
    The struggles of translational medicine in ischemia-reperfusion injury
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 54, 2012, Cardiac protection in acute cardiac syndrome

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  • EDITORIAL
    Cardiac protection in acute cardiac syndrome
    M. Marzilli
  • BASIC ARTICLE
    Magnitude and relevance of reperfusion injury
    D. J. Hausenloy
    Keywords: myocardial reperfusion injury, primary percutaneous coronary intervention (PPCI), ST-segment elevation myocardial infarction (STEMI)
  • MAIN CLINICAL ARTICLE
    Pharmacological cardiac protection
    E. Orsini, M. Marzilli, D. Morrone, P. Capozza, A. Huqi, F. L. Dini, and G. Guarini
    Keywords: ischemia-reperfusion injury, cardioprotection, preconditioning, postconditioning, mitochondrial permeability transition pore, adenosine
  • METABOLIC IMAGING
    Magnetic resonance imaging of the microcirculation in acute coronary syndromes
    K. De Silva, J. Baker, A. Kidambi, D. Perera and S. Plein
    Keywords: microvascular dysfunction, magnetic resonance imaging (MRI), acute coronary syndrome, myocardial infarction
  • NEW THERAPEUTIC APPROACHES
    Postconditioning
    M. Marzilli, D. Morrone and G. Guarini
    Keywords: ischemia reperfusion injury, cardioprotection, post-conditioning, remote conditioning
  • FOCUS ON Vastarel® MR
    Metabolic cardiac protection
    G. Guarini
    Keywords: cardiac ischemia, ischemia/reperfusion injury, cardioprotection, trimetazidine
  • CASE REPORT
    Myocardial infarction with contemporary bivasal occlusion: one case, two fates
    P. Capozza and M. Marzilli
    Keywords: myocardial infarction, adenosine, cardioprotection, microcirculation
  • REFRESHER CORNER
    Myocytes versus endothelial damage
    F. L. Dini, E. Orsini, M. Marzilli and G. Guarini
    Keywords: ischemic injury, reperfusion injury, endothelial damage, cardioprotection
  • HOT TOPICS
    The heart failure and obesity paradox: would you suggest your patients gain weight?
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 53, 2011, Energetics in heart disease

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  • EDITORIAL
    Energetics in heart disease
    D. Feuvray
  • BASIC ARTICLE
    Myocardial energetics and efficiency
    E. Aasum
    Keywords: cardiac energy metabolism, oxygen consumption, mechano energetics, heart failure
  • MAIN CLINICAL ARTICLE
    Modulation of cardiac energetics as a target in ischemic heart disease
    H. Ashrafian
    Keywords: cardiac energetics, ischemic heart disease, metabolic therapies, cardiac metabolism
  • METABOLIC IMAGING
    Glucose metabolism as a marker of myocardial ischemia
    P. G. Camici
    Keywords: coronary artery disease, myocardial metabolism, myocardial ischemia, positron emission tomography.
  • NEW THERAPEUTIC APPROACHES
    An expanded role for AMP kinase: self-renewal of the cardiomyocyte
    K. Baskin and H. Taegtmeyer
    Keywords: AMPK, protein degradation, cardiac metabolism
  • FOCUS ON TRIMETAZIDINE (Vastarel® MR)
    Beneficial effects of trimetazidine (Vastarel® MR) in patients with chronic heart failure
    G. Fragasso, L. Alberti and L. Lauretta
    Keywords: systolic-dysfunction, heart failure, left ventricular function, metabolic therapy, energy expenditure
  • CASE REPORT
    Myocardial power delivery is impaired in progressive left ventricular pump failure: a case report
    F. L. Dini
    Keywords: heart failure, dilated cardiomyopathy, echo stress
  • REFRESHER CORNER
    Impact of fatty acid oxidation on cardiac efficiency
    N. Fillmore and G. D. Lopaschuk
    Keywords: fatty acid ß-oxidation, uncoupling proteins, mitochondrial thioesterase, glucose oxidation, glycolysis
  • HOT TOPICS
    Statin therapy: reduction in cardiovascular events still pays in new-onset diabetes
    A. Huqi
  • GLOSSARY
    G. D. Lopaschuk

Number 52, 2011, Equality of care for the elderly

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  • EDITORIAL
    Equality of care for the elderly
    Graham Jackson
  • BASIC ARTICLE
    Energy metabolism in the aging heart
    Jason R.B. Dyck, Miranda M.Y. Sung
    Keywords: aging, myocardial metabolism, contractile dysfunction, mitochondria
  • MAIN CLINICAL ARTICLE
    Managing angina in the elderly: the impact of comorbidities
    Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Christodoulos Stefanadis
    Keywords: elderly, coronary artery disease, angina; comorbidities
  • METABOLIC IMAGING
    Cardiac computed tomography in the elderly: windows into a lifetime of exposure to cardiac risk
    Gary R. Small, Benjamin J.W. Chow, Terrence D. Ruddy
    Keywords: cardiac CT, coronary calcification, risk stratification, elderly
  • NEW THERAPEUTIC APPROACHES
    Transcatheter aortic valve implantation in the elderly: current state of play
    Aung Myat, Muhammed Zeeshan Khawaja, Hari Haran, Kaleab Asrress, Simon Redwood
    Keywords: TAVI, aortic stenosis, transfemoral, transapical, stroke, surgical AVR
  • FOCUS ON VASTAREL® MR
    Quality of life with trimetazidine
    Giuseppe Marazzi
    Keywords: ischemic cardiomyopathy, trimetazidine, quality of life
  • CASE REPORT
    Metabolic approach to ischemic heart disease in the elderly
    Cristiana Vitale
    Keywords: elderly, ischemic heart disease, arterial peripheral disease, trimetazidine
  • REFRESHER CORNER
    Improving the quality of sex life in the elderly
    J.M. Tomlinson
    Keywords: ageing, sex life, elderly, PDE5 inhibitors, hormone replacement therapy, retirement homes
  • HOT TOPICS
    Medical therapy versus revascularization rounds: ischemic heart failure on focus
    Alda Huqi
  • GLOSSARY
    Gary D. Lopaschuk

Number 51, 2011, Cancer and the heart

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  • EDITORIAL
    The rising tide of cardiotoxicity associated with cancer chemotherapy
    Gary D. Lopaschuk
  • BASIC ARTICLE
    Cardiotoxicity in cancer therapeutics
    Christian Zuppinger
    Keywords: cancer therapy, cardiotoxicity, anthracyclines, cell death, mitochondria
  • MAIN CLINICAL ARTICLE
    Assessing and monitoring cardiac function in cancer patients
    K. von Klemperer, K. Fox
    Keywords: cancer, chemotherapy, heart failure, cardiotoxicity
  • METABOLIC IMAGING
    Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer
    Mukesh K. Pandey, Aditya Bansal, Timothy R. DeGrado
    Keywords: PET, fatty acid oxidation, thia fatty acid, FTHA, FTP, FTO
  • NEW THERAPEUTIC APPROACHES
    Metabolic modulation as a novel cancer treatment
    Peter Dromparis, Gopinath Sutendra, Evangelos D. Michelakis
    Keywords: cancer, metabolic, apoptosis, dichloroacetate, glycolysis
  • FOCUS ON VASTAREL® MR
    Cancer and inhibition of fatty acid oxidation
    Alda Huqi
    Keywords: cancer, Warburg effect, metabolic modulation therapy, fatty acid oxidation
  • CASE REPORT
    A case of multifactorial late left ventricular dysfunction after cancer treatment
    Chiara Lestuzzi
    Keywords: cardiotoxicity, radiotherapy, left ventricular dysfunction, Hodgkin’s disease, coronary artery disease, dyslipidemia
  • REFRESHER CORNER
    The Warburg effect – aerobic glycolysis in proliferating cells
    Jagdip S. Jaswal
    Keywords: cellular proliferation, glycolysis, glucose oxidation, cellular biosynthesis
  • HOT TOPICS
    Warfarin and dabigatran: an historical handover?
    Alda Huqi

Number 50, 2011, Changing epidemiology of ischemic heart disease

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  • EDITORIAL
    Changing epidemiology of ischemic heart disease
    Mario Marzilli
  • BASIC ARTICLE
    Emerging patterns in IHD in developing countries
    Raffaele Bugiardini
    Keywords: Epidemiology, Europe, ISACS-CT, ischemic heart disease, MONICA
  • MAIN CLINICAL ARTICLE
    The changing face of acute coronary syndromes
    Steven E. Williams, Christopher N. Floyd, Michael Marber
    Keywords: Acute coronary syndrome, angiography, angioplasty, myocardial infarction, non-ST-segment elevation, NSTEMI, percutaneous intervention, revascularization, STEMI, ST-segment elevation
  • METABOLIC IMAGING
    Detecting acute coronary syndromes by magnetic resonance imaging
    Afshin Farzaneh-Farab, Raymond Y. Kwongc
    Keywords: Acute coronary syndrome, chest pain, magnetic resonance imaging, myocardial infarction, unstable angina
  • NEW THERAPEUTIC APPROACHES
    Stable angina and female gender
    Alda Huqi, Paola Capozza, Mario Marzilli
    Keywords: Coronary artery disease, gender differences, ischemic heart disease
  • FOCUS ON VASTAREL® MR
    Clinical benefits of trimetazidine (Vastarel® MR) in the changing scenario of ischemic heart disease
    Elena Louette
    Keywords: Cardiac energy metabolism, cardioprotection, diabetes, IHD, LV dysfunction, trimetazidine MR
  • CASE REPORT
    Coronary microcirculation in effort ischemia: the roar of the rabbit
    Paola Capozza, Enrico Orsini
    Keywords: Coronary angiography, coronary slow flow, myocardial ischemia
  • REFRESHER CORNER
    Lessons from EUROASPIRE I, II, and III surveys
    Kornelia Kotseva
    Keywords: Cardiovascular disease (CVD), coronary heart disease (CHD), EUROASPIRE, lifestyle and risk-factor management
  • HOT TOPICS
    Interventional therapy for resistant hypertension: new hopes and old concerns!
    Alda Huqi
  • GLOSSARY
    Gary D. Lopaschuk

Number 49, 2011, Dilated cardiomyopathy

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  • EDITORIAL
    Dilated cardiomyopathy
    G. Jackson
  • BASIC ARTICLE
    Myocardial energy metabolism in dilated cardiomyopathy
    W. C. Stanley
    Keywords: fatty acids, glucose, heart failure, mitochondria
  • MAIN CLINICAL ARTICLE
    Drugs and/or devices in dilated cardiomyopathy
    H. P. Schultheiss, U. Kühl
    Keywords: Anti-viral or immunomodulatory treatment, autoimmunity, dilated cardiomyopathy,heart failure therapy, ICD, immunosuppression, myocarditis
  • METABOLIC IMAGING
    Metabolic imaging in dilated cardiomyopathy
    S. Neubauer
    Keywords: Dilated cardiomyopathy, energetics, magnetic resonance spectroscopy, metabolism, steatosis
  • NEW THERAPEUTIC APPROACHES
    Metabolic modulation in dilated cardiomyopathy
    H. Tuunanen, J. Knuuti
    Keywords: etomoxir, Heart failure, metabolism, perhexiline, trimetazidine
  • FOCUS ON VASTAREL MR
    The clinical benefits provided by trimetazidine in left ventricular dysfunction patients
    G Marazzi, G. Caminiti, M. Voterrani
    Keywords: Chronic heart failure, left ventricular function, metabolic therapy, trimetazidine
  • CASE REPORT
    Response to cardiac resynchronization therapy resulting from an upgrade to dual-site left ventricular pacing
    M. R. Ginks, S. G. Duckett, G. S. Carr-White, C. A. Rinaldi
    Keywords: Cardiac resynchronization therapy, multi-site pacing, non-responder
  • REFRESHER CORNER
    Cardiac amyloidosis
    P. Schmidheiny, O. M. Hess
    Keywords: Autologous stem cell transplantation, cardiac amyloidosis, cardiac arrhythmias, endomyocardial biopsy, restrictive cardiomyopathy
  • HOT TOPICS
    Low diagnostic yield of coronary angiography or not catching up with heart disease pathophysiology?
    A Huqi
  • GLOSSARY
    Gary D. Lopaschuk

Number 48, 2010, Obesity and heart disease

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  • EDITORIAL
    Obesity and heart disease
    Gary D. Lopaschuk
  • BASIC ARTICLE
    Free fatty acid oxidation in insulin resistance and obesity
    E. Dale Abel
  • MAIN CLINICAL ARTICLE
    Obesity and mortality: summary of best evidence with explanations for the obesity paradox
    Jennifer Logue, Naveed Sattar
  • METABOLIC IMAGING
    Functional imaging of brown adipose tissue
    Kirsi A. Virtanena, Pirjo Nuutilaab
  • NEW THERAPEUTIC APPROACHES
    Stimulating brown fat: a potential future therapeutic approach for obesity and insulin resistance?
  • FOCUS ON VASTAREL MR
    Clinical benefits of trimetazidine in diabetic patients with coronary artery disease
    Samir S. Wafa
  • CASE REPORT
    Comorbidity in the obese patient: the paroxysmal Pickwickian with pulmonary peculiarities and poor pump performance
    Ian G. Webb, Michael Marber
  • REFRESHER CORNER
    Mitochondrial uncoupling proteins
    Frédéric Bouillaud
  • Hot topics
    Risk factor modification and cardiovascular events: the gap is not yet bridged
    Alda Huqi
  • Hot topics
    Abstracts and Commentaries: A new link between obesity and heart disease
    Danielle Feuvray
  • Glossary
    Gary D. Lopaschuk

Number 47, 2010, What becomes of the brokenhearted?

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  • EDITORIAL
    What becomes of the brokenhearted?
    Michael Marber
  • BASIC ARTICLE
    Basic mechanisms in apoptosis and heart failure
    Roger Foo
  • MAIN CLINICAL ARTICLE
    Role of RAAS inhibition in preventing left ventricular remodeling in patients post myocardial infarction
    Doralisa Morrone, Mario Marzilli
  • METABOLIC IMAGING
    Magnetic resonance imaging to assess ventricular remodeling
    Otavio R. Coelho-Filhoa, Raymond Y. Kwonga, Michael Jerosch-Heroldb
  • NEW THERAPEUTIC APPROACHES
    Toll-like receptors: emerging therapeutic targets for heart failure
    Stefan Frantz, Johann Bauersachs
  • FOCUS ON VASTAREL MR
    Clinical overview of trimetazidine (Vastarel MR) in patients with heart failure
    Tiina Uuetoa
  • CASE REPORT
    Left ventricular remodeling after acute myocardial infarction with microvascular obstruction
    Robin Nijveldt, Albert C. van Rossum
  • REFRESHER CORNER
    Ivabradine (Procoralan) alone or with ß-blockers in myocardial ischemia
    Alain Berdeaux
  • HOT TOPICS
    Strategies to prevent left ventricular remodeling
    Alda Huqi
  • HOT TOPICS
    Early diagnosis of myocardial infarction
    Michael Marber
  • GLOSSARY
    Gary D. Lopaschuk
    Download this article as a pdf file

Number 46, 2010, The cardiac cell: its survival and performance

Number 45, 2009, Diabetes and cardiovascular disease

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  • EDITORIAL
    Diabetes and cardiovascular disease
    Gary D. Lopaschuk
  • BASIC ARTICLE
    Non ischemic heart failure in diabetes mellitus: still incompletely understood
    Romain Harmancey, Heinrich Taegtmeyer
  • MAIN CLINICAL ARTICLE
    Clinical manifestations of diabetic cardiomyopathy
    Sihem Boudina
  • METABOLIC IMAGING
    Nuclear magnetic resonance for the study of cardiac metabolism in diabetes
    Giancarlo Todiere, Mario Marzilli
  • NEW THERAPEUTIC APPROACHES
    Cardiac considerations in the treatment of the metabolic syndrome
    David S.H. Bell
  • FOCUS ON VASTAREL MR
    Clinical benefits of trimetazidine in patients with coronary artery disease and diabetes mellitus
    Luis Rodríguez Padial
  • CASE REPORT
    Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis
    Maurizio Galderisi, Rosa Raia
  • EDITORIAL COMMENT
    Editorial comment to the article “Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis” by Maurizio Galderisi and Rosa Raia
    Mario Marzilli
  • REFRESHER CORNER
    Energy metabolism in the heart of the diabetic patient
    Danielle Feuvray
  • FEATURED RESEARCH
    Abstracts and Commentaries
    Jagdip S. Jaswal, Gary D. Lopaschuk
  • GLOSSARY
    Gary D. Lopaschuk

Number 44, 2009, Circadian rhythms and cardiovascular disease

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  • EDITORIAL
    Circadian rhythms and cardiovascular disease
    Danielle Feuvray
  • BASIC ARTICLE
    Diurnal variations in myocardial metabolism
    Ju-Yun Tsai, Martin E. Young
  • MAIN CLINICAL ARTICLE
    Disruption of normal circadian rhythms and cardiovascular events
    Alberto Dominguez-Rodrigueza, Pedro Abreu-Gonzalezb, Juan Carlos Kaskic
  • METABOLIC IMAGING
    Metabolic imaging with cardiac magnetic resonance spectroscopy
    Stefan Neubauer
  • NEW THERAPEUTIC APPROACHES
    Rev-erba: a potential target for the treatment of circadian disorders
    Hélène Duezabcd, Bart Staelsabcd
  • FOCUS ON VASTAREL MR
    Beneficial effects of Vastarel MR in protecting patients with stable coronary artery disease against early morning ischemic burden
    Stephane Coquempot
  • CASE REPORT
    Jet lag
    Graham Jackson
  • REFRESHER CORNER
    Melatonin and cardiac pathophysiology
    Russel J. Reiter, Dun X. Tan
  • FEATURED RESEARCH
    Abstracts and Commentaries
    Mario Marzilli
  • GLOSSARY
    Gary D. Lopaschuk

Number 43, 2009, Biomarkers: past, present and future

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  • TO OUR READERS
    Change of Editor-in-Chief of Heart and Metabolism
  • EDITORIAL
    Biomarkers: past, present and future
    Graham Jackson
  • BASIC ARTICLE
    The biological basis of troponin in heart disease: possible uses for troponin fragmentology
    Vlad C. Vasile, Allan S. Jaffe
  • MAIN CLINICAL ARTICLE
    The role of biomarkers in clinical practice
    Anthony S. Wierzbickia, Adie Viljoenb
  • METABOLIC IMAGING
    Troponin compared with late enhancement in the assessment of myocardial injury
    Evangelos Giannitsis, Hugo A. Katus
  • NEW THERAPEUTIC APPROACHES
    Trends in genomic biomarkers
    Bruce McManus
  • FOCUS ON VASTAREL MR
    Effects of Vastarel MR on brain natriuretic peptide and cardiac troponin concentrations
    Pericle Di Napoli
  • CASE REPORT
    Serial determination of troponin concentrations in the diagnosis of acute myocardial infarction
    Vlad C. Vasile, Lori A. Blauwet, Allan S. Jaffe
  • REFRESHER CORNER
    Temporal profile of protein release in myocardial infarction
    Piero Montorsi, Marco Villa, Maria Antonietta Dessanai
  • FEATURED RESEARCH
    Abstracts and Commentaries
    Mario Marzilli
  • GLOSSARY
    Gary D. Lopaschuk

Number 42, 2009, Chronic ischemic heart disease

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  • EDITORIAL
    Chronic ischemic heart disease
    Mario Marzilli
  • BASIC ARTICLE
    Genomics, transcriptomics, and proteomics of the ischemic heart
    Marcus C. Schauba, Eliana Lucchinettib, Michael Zauggb
  • MAIN CLINICAL ARTICLE
    Identifying patients at risk of progressive left ventricular dysfunction
    Florence Pinet
  • METABOLIC IMAGING
    Magnetic resonance imaging and positron emission tomography as predictors of heart failure
    Christoph Klein
  • NEW THERAPEUTIC APPROACHES
    Targeting oxidative stress in heart failure
    Leong L. Ng
  • FOCUS ON VASTAREL MR
    Beneficial long-term effects of Vastarel MR in patients with stable coronary artery disease developing left ventricular dysfunction
    Hamayak S. Sisakian
  • CASE REPORT
    Changing ischemic symptoms despite stable coronary anatomy
    Mario Marzilli, Alda Huqi
  • REFRESHER CORNER
    Hibernation or repetitive stunning – does it matter?
    Gerd Heuscha, Rainer Schulzb
  • The clinical perspective
    I. Rahman, R.S. Bonser
  • FEATURED RESEARCH
    Abstracts and Commentaries
    Danielle Feuvray
  • GLOSSARY
    Gary D. Lopaschuk

Number 41, 2008, Taking genes to heart

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  • EDITORIAL
    Taking genes to heart
    Michael S. Marber
  • BASIC ARTICLE
    Genetics of cardiomyopathy and channelopathy
    Connie R. Bezzina
  • MAIN CLINICAL ARTICLE
    What the practicing cardiologist needs to know about genetics and heart disease
    Rahul C. Deo, Calum A. MacRae
  • METABOLIC IMAGING
    Imaging of myocardial receptors: applications in the evaluation of cardiac disease
    Ornella Rimoldiabc, Paolo G. Camiciab
  • NEW THERAPEUTIC APPROACHES
    Gene therapy for cardiovascular manifestations of lysosomal storage diseases
    Meg M. Sleepera, Mark E. Haskinsb, Katherine P. Ponderc
  • FOCUS ON VASTAREL MR
    Anti-ischemic cardioprotection with trimetazidine
    Pericle Di Napoli
  • CASE REPORT
    Long-QT syndrome in a family with a KCNH2 mutation
    Cliona Murphy, Jas Gill
  • REFRESHER CORNER
    How do mutations cause disease?
    Jean-Jacques Mercadier
  • FEATURED RESEARCH
    Abstracts and commentaries
    Mario Marzilli
  • GLOSSARY
    Gary D. Lopaschuk

Number 40, 2008, Coronary microvascular disease

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  • EDITORIAL
    Coronary microvascular disease
    Mario Marzilli
  • BASIC ARTICLE
    Microvascular control of myocardial perfusion
    Helmut Habazettl, Axel R. Pries
  • MAIN CLINICAL ARTICLE
    Prognostic significance of microvascular dysfunction
    Michael Weis
  • METABOLIC IMAGING
    Non invasive assessment of coronary microvascular dysfunction
    Frans Visser
  • NEW THERAPEUTIC APPROACHES
    Improving perfusion at reperfusion
    Mario Marzilli
  • FOCUS ON VASTAREL MR
    Reperfusion injury: reduction by Vastarel MR
    Laurent Bonello, Franck Paganelli
  • CASE REPORT
    Microvascular obstruction after primary angioplasty: beyond the epicardial artery
    Tim Lockie, Sven Plein, Simon Redwood
  • REFRESHER CORNER
    Cardiac syndrome X: pathogenesis and management
    Juan Carlos Kaski, Kamran Iqbal
  • FEATURED RESEARCH
    Abstracts and commentaries
    Mario Marzilli
  • GLOSSARY
    Gary D. Lopaschuk

Number 39, 2008, Cardiac Efficiency in Health and Disease

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  • EDITORIAL
    Measuring cardiac efficiency: is it clinically useful?
    Frans Visser
  • BASIC ARTICLE
    Molecular basis of cardiac efficiency
    Heiko Bugger, E. Dale Abel
  • MAIN CLINICAL ARTICLE
    Assessment and clinical applications of myocardial efficiency
    Olakunle Akinboboye
  • METABOLIC IMAGING
    Myocardial efficiency in heart failure: non invasive imaging
    Paul Knaapen, Tjeerd Germans
  • NEW THERAPEUTIC APPROACHES
    Improvement of cardiac efficiency in heart failure by cardiac resynchronization therapy
    Matthew Ginks, C. Aldo Rinaldi
  • FOCUS ON VASTAREL MR
    Benefits of the metabolic approach in cardiac rehabilitation
    Romualdo Belardinelli
  • CASE REPORT
    Improvement of myocardial efficiency in a patient with hypertrophic obstructive cardiomyopathy after alcohol septal ablation
    Tjeerd Germans12*, Paul Knaapen1, Albert C. van Rossum12
  • REFRESHER CORNER
    Invasive assessment of cardiac efficiency
    Paul Steendijk, Ellen A. ten Brinke
  • FEATURED RESEARCH
    Abstracts and commentaries
    Danielle Feuvray
  • GLOSSARY
    Gary D. Lopaschuk

Number 38, 2008, Stable angina – taking time

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  • EDITORIAL
    Stable angina – taking time
    Graham Jackson
  • BASIC ARTICLE
    Optimizing cardiac energy substrate metabolism: a novel therapeutic intervention for ischemic heart disease
    Jagdip S. Jaswal, Virgilio J.J. Cadete, Gary D. Lopaschuk
  • MAIN CLINICAL ARTICLE
    Stable angina: a balanced approach
    Jon-David Schwalm, Koon K. Teo
  • METABOLIC IMAGING
    Magnetic resonance perfusion imaging for detection of ischemic heart disease
    Eike Nagel
  • NEW THERAPEUTIC APPROACHES
    Coronary microcirculation: the new frontier in coronary artery disease
    Mario Marzilli
  • FOCUS ON VASTAREL MR
    Efficacy of Vastarel MR on silent and symptomatic myocardial ischemia
    Giuseppe Caminiti, Giuseppe Marazzi, Giuseppe Rosano
  • CASE REPORT
    Trimetazidine in the management of ischemic heart disease in a patient with diabetes mellitus and recurrent angina
    Mario Marzilli
  • REFRESHER CORNER
    The place of exercise in the patient with chronic stable angina
    Anil Nigam, Jean-Claude Tardif
  • FEATURED RESEARCH
    Abstracts and commentaries
    Danielle Feuvray
  • GLOSSARY
    Gary D. Lopaschuk

Number 37, 2007, Go with the flow

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  • EDITORIAL
    Go with the flow
    Michael Marber
  • BASIC ARTICLE
    Consequences of reperfusion
    Thorsten Reffelmann and Robert A. Kloner
    Keywords: Ischemic preconditioning, myocardial salvage, no reflow, reperfusion, stunning
  • MAIN CLINICAL ARTICLE
    Measuring reperfusion in the catheter laboratory
    Ian Webb and Simon Redwood
    Keywords: Microvascular dysfunction, primary angioplasty, reperfusion
  • METABOLIC IMAGING
    Scoring reperfusion by contrast-enhanced magnetic resonance imaging
    Giuseppe Tarantini and Sabino Iliceto
    Keywords: Acute myocardial infarction, magnetic resonance imaging, primary angioplasty
  • NEW THERAPEUTIC APPROACHES
    Postconditioning the human heart
    Hélène Thibault, Denis Angoulvant, Cyrille Bergerot and Michel Ovize
    Keywords: Ischemia, myocardial infarction, postconditioning, reperfusion
  • FOCUS ON TRIMETAZIDINE (VASTAREL MR)
    Clinical benefi ts of a metabolic approach in the treatment of ischemic heart disease: focus on Vastarel MR
    Mario Marzilli
    Keywords: Angina, cardiac energy metabolism, ischemic heart disease, trimetazidine
  • CASE REPORT
    Primary angioplasty: worth the trouble?
    Mrinal Saha
    Keywords: Acute myocardial infarction, bifurcation disease, clopidrogrel, kissing balloons, primary angioplasty
  • REFRESHER CORNER
    The paradoxes of reperfusion in the ischemic heart
    Naranjan S. Dhalla and Todd A. Duhamel
    Keywords: Calcium-overload, cardiac dysfunction, ischemic myocardium, oxidative stress, reperfusion injury, subcellular remodeling
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary D. Lopaschuk

Number 36, 2007, Improving prognosis in ischemic heart disease: time to maximize benefit

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  • EDITORIAL
    Improving prognosis in ischemic heart disease: time to maximize benefit
    Graham Jackson
  • BASIC ARTICLE
    The atherosclerotic plaque was not built in a day: the dynamic nature of plaque progression and instability
    Martin R. Bennett
    Keywords: Vascular smooth muscle cells, apoptosis, atherosclerosis, vascular, inflammation
  • MAIN CLINICAL ARTICLE
    Pharmacologic prevention of coronary plaque rupture – the major cause of acute coronary syndromes
    Petri T. Kovanen and Markku O. Pentikäinen
    Keywords: Coronary artery disease, plaque rupture, pharmacotherapy
  • METABOLIC IMAGING
    Metabolic imaging: the role of imaging in risk evaluation of ischemic heart disease
    Mark T. Harbinson
    Keywords: Ischemic heart disease, metabolic tracers, myocardial perfusion imaging, nuclear cardiology, prognosis
  • NEW THERAPEUTIC APPROACHES
    Beyond pharmacology in heart attacks: coronary stents and stem cells
    Cheuk-Kit Wong, Neal S. Kleiman and Harvey D. White
    Keywords: Myocardial infarction, stem cells, stents
  • The Emperor has no clothes: reading between the lines of the COURAGE report
    Mario Marzilli
    Keywords: Angina, coronary artery disease, ischemic syndromes, percutaneous coronary intervention, percutaneous transluminal coronary angioplasty
  • FOCUS ON VASTAREL MR
    The metabolic approach to improving prognosis in ischemic heart disease
    Pericle Di Napoli
    Keywords: Trimetazidine, heart failure, ischemic heart disease, prognosis
  • CASE REPORT
    You are never too old
    Cristiana Vitale
    Keywords: Compliance, elderly, prognosis, trimetazidine
  • REFRESHER CORNER
    Reducing the risks in diabetes
    Giuseppe Rosano and Maria Cristina Ribaudo
    Keywords: Cardiovascular events, diabetes mellitus, risk, cholesterol, hypertension, exercise
  • FEATURED RESEARCH
    Abstracts and Commentaries
    Gary Lopaschuk
  • GLOSSARY
    Gary D. Lopaschuk

Number 35, 2007, Cardiac toxicity

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  • EDITORIAL
    Cardiac toxicity
    Danielle Feuvray
  • BASIC ARTICLE
    Molecular basis of anthracycline-induced cardiotoxicity
    Richard S. Vander Heide and Thomas J. L’Ecuyer
    Keywords: Anthracycline, cardiotoxicity, cardiac muscle, oxidative stress, apoptosis, mechanism
  • MAIN CLINICAL ARTICLE
    Mechanisms, manifestations, and management of digoxin toxicity
    Lionel G. Lelièvre and Philippe Lechat
    Keywords: Arrhythmias, digoxin, cardiotoxicity, human Naþ/Kþ-ATPase isoforms, ventricular tachycardia
  • METABOLIC IMAGING
    Myocardial perfusion imaging and cardiac events in asymptomatic patients with diabetes
    Denis Mariano-Goulart
    Keywords: Diabetes mellitus, occult coronary artery disease, myocardial perfusion imaging, scintigraphy, screening
  • NEW THERAPEUTIC APPROACHES
    Role of ATP-binding cassette transporters in drug distribution to the heart and protection from toxic compounds
    Lucie Couture, John. A. Nash and Jacques Turgeon
    Keywords: ABC transporters, cardiac drug distribution, cardiotoxicity, drug efflux, heart protection
  • FOCUS ON TRIMETAZIDINE (VASTAREL MR)
    The importance of a metabolic approach to anti-ischemic protection
    Graham Jackson
    Keywords: Ischemia, ischemic burden, metabolic agents, trimetazidine
  • CASE REPORT
    Trimetazidine and left ventricular dysfunction: patients must play their part also
    Graham Jackson
    Keywords: Alcohol excess, pre-diabetes, left ventricular dysfunction, lifestyle, trimetazidine
  • REFRESHER CORNER
    Preventing the cardiotoxic effects of anthracyclines: from basic concepts to clinical data
    Catherine Vergely, Stéphanie Delemasure, Yves Cottin and Luc Rochette
    Keywords: Anthracyclines, cardiotoxicity, congestive heart failure, reactive oxygen species, ACE inhibitors
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 34, 2007, New imaging methods for patients with coronary artery disease

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  • EDITORIAL
    Picture my heart!
    Michael Marber
  • BASIC ARTICLE
    Coronary computed tomographic angiography: current and future uses
    Birgit Kantor, Ronald S. Kuzo and Thomas C. Gerber
    Keywords: Angiography, computed tomography, coronary artery disease, diagnosis
  • MAIN CLINICAL ARTICLE
    Perspectives of new imaging techniques for patients with known or suspected coronary artery disease
    Joanne D. Schuijf and Jeroen J. Bax
    Keywords: Non invasive imaging, coronary artery disease
  • METABOLIC IMAGING
    The future of positron emission tomography/computed tomography imaging of the heart
    Philipp A. Kaufmann
  • NEW THERAPEUTIC APPROACHES
    Cardiac interventions guided by magnetic resonance imaging
    Titus Kuehne
    Keywords: Magnetic resonance imaging, intervention, congenital heart disease
  • FOCUS ON VASTAREL MR
    Effi cacy of the metabolic approach in ischemic heart diseases. Non invasive assessment of myocardial perfusion, metabolism, and left ventricular function
    Romualdo Belardinelli
    Keywords: Metabolic modulation, chronic myocardial ischemia, trimetazidine, dobutamine stress echocardiography, SPECT imaging
  • CASE REPORT
    Multislice computed tomography coronary angiography before percutaneous recanalization of chronic total occlusions
    N. R. Mollet, N. Van Pelt, G. Sianos, W.B. Meijboom, F. Cademartiri and P.J. de Feyter
    Keywords: Chronic total occlusion, coronary artery, multislice computed tomography, percutaneous revascularization
  • REFRESHER CORNER
    Obtaining cardiac images from positron emission tomography, computed tomography, and magnetic resonance imaging: physical principles
    Ronald Boellaard
    Keywords: Physical principles, positron emission tomography, computed tomography, magnetic resonance imaging, cardiology, structural, functional, molecular, imaging
  • FEATURED RESEARCH
    Abstracts and commentaries

Number 33, 2006, Arrhythmia and metabolism

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  • EDITORIAL
    Arrhythmia and metabolism
    Danielle Feuvray
  • BASIC ARTICLE
    Metabolic signals of arrhythmia
    Jason R.B.Dyck and Peter E. Light
    Keywords: Arrhythmia, cardiac energy metabolism, ion channels, AMPK, PRKAG2
  • MAIN CLINICAL ARTICLE
    Metabolic gene defects and risk of arrhythmia
    Patrick T. Ellinor, David J. Milan and Calum A. MacRae
    Keywords: Glycogen, fatty acid, mitochondrial, atrial fibrillation, ventricular tachycardia
  • METABOLIC IMAGING
    Imaging and arrhythmia
    Reza Razavi
    Keywords: Arrhythmia, echocardiography, computed tomography, magnetic resonance imaging
  • NEW THERAPEUTIC APPROACHES
    New therapeutic approaches in atrial fi brillation
    Bas A. Schoonderwoerd and Isabelle C. Van Gelder
    Keywords: Atrial fibrillation, antiarrhythmic drugs, anticoagulation, radiofrequency ablation, treatment
  • FOCUS ON VASTAREL MR
    Modulation of metabolic changes in patients with heart failure by selective inhibition of 3-ketoacyl coenzyme A thiolase
    Gabriele Fragasso, Altin Palloshi, Amarild Cuko and Roberto Spoladore
    Keywords: Trimetazidine, heart failure, left ventricular function, glucose metabolism, free fatty acids
  • CASE REPORT
    Anderson-Fabry disease: an important differential diagnosis in patients with unexplained left ventricular hypertrophy
    Perry Elliott
    Keywords: Anderson–Fabry disease, left ventricular hypertrophy, women
  • REFRESHER CORNER
    Cellular changes in atrial fi brillation
    Jolanda van der Velden, Nadiya A. Narolska and Ger J.M. Stienen
    Keywords: Atrial fibrillation, contractility, cardiomyocyte function, contractile proteins
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 32, 2006, Metabolic profile in heart disease

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  • EDITORIAL
    Metabolic profi le in heart disease
    Mario Marzilli
  • BASIC ARTICLE
    Understanding the metabolic phenotype of heart disease
    Rong Tian
    Keywords: energetics, heart failure, transgenic mice, fatty acid oxidation, glucose metabolism, metabolic therapy
  • MAIN CLINICAL ARTICLE
    Clinical implications of energetic problems in cardiovascular disease
    John R. Ussher and Gary D. Lopaschuk
    Keywords: Fatty acid oxidation, trimetazidine, glucose oxidation, energy metabolism
  • METABOLIC IMAGING
    Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy
    Michiel ten Hove and Stefan Neubauer
    Keywords: 31P-Magnetic resonance spectroscopy, 1H-magnetic resonance spectroscopy, 13C-magnetic resonance spectroscopy, cardiac metabolism
  • NEW THERAPEUTIC APPROACHES
    Metabolic profiling in heart disease
    David J. Grainger
    Keywords: Metabonomics, atherosclerosis, myocardial infarction, pronostics
  • FOCUS ON VASTAREL MR
    Trimetazidine and the metabolic profi le of ischemia
    Graham Jackson
    Keywords: Heart disease, left ventricular function, myocardial metabolism, prognosis, trimetazidine
  • CASE REPORT
    Altered AMP-activated protein kinase activity and pathologic cardiac disease
    Michael H. Gollob, Martin S. Green and John P. Veinot
    Keywords: AMP-activated protein kinase (or AMPK), Wolff–Parkinson–White, arrhythmia, glycogen storage disease, hypertrophy, genetics
  • REFRESHER CORNER
    Regulation of gene expression by polyunsaturated fatty acids
    Harini Sampath and James M. Ntambi
    Keywords: Polyunsaturated fatty acids, SREBP1c, PPAR, LXR
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 31, 2006, Persistent angina: the good, the bad, and the ugly

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  • EDITORIAL
    Persistent angina: the good, the bad, and the ugly
    Frans C. Visser
  • BASIC ARTICLE
    Oxidative stress and ischemia
    Joël de Leiris, Andry Rakotovao and François Boucher
    Keywords: Oxidative stress, free radicals, myocardial ischemia, reperfusion, cellular injury
  • MAIN CLINICAL ARTICLE
    Persistent angina
    Mario Marzilli, Marta Focardi, Silvia Affi nito, Eugenia Capati and Rossella Urselli
    Keywords: Persistent angina, percutaneous transluminal coronary angioplasty, coronary stenosis, randomised intervention treatment of angina trial, arterial revascularization therapy study
  • IMAGING
    Cardiac imaging for the detection of ischemia after percutaneous coronary intervention
    Kenneth N. Giedd
    Keywords: Computed tomography angiography, myocardial perfusion imaging, percutaneous coronary intervention
  • NEW THERAPEUTIC APPROACHES
    Exciting developments in stable angina – the rise of the f-channels
    Adrian J. B. Brady
    Keywords: Angina, b-blockers, heart rate, cardiac ion channels, f-channels, If current, ivabradine
  • FOCUS ON VASTAREL MR
    From recurrent ischemia to ischemic heart failure: new data on trimetazidine
    Jaroslaw D. Kasprzak
    Keywords: Ischemic cardiomyopathy, heart failure, recurrent ischemia, trimetazidine
  • CASE REPORT
    Persistent angina after myocardial revascularization: a case report
    Marta Focardi, Eugenia Capati, Silvia Affi nito, Rossella Urselli and Mario Marzilli
    Keywords: Persistent angina, complete myocardial revascularization, microvascular angina, stable angina, stress test ischemia
  • REFRESHER CORNER
    Warm up angina
    Rainer Zbinden and Michael S. Marber
    Keywords: Angina, ischemic preconditioning, myocardial collaterals
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 30, 2006, Metabolic syndrome and its management

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  • EDITORIAL
    Metabolic syndrome and its management
    Gary Lopaschuk
  • BASIC ARTICLE
    Lipotoxicity in cardiac and skeletal muscle
    Jennifer L. Peura and Jean E. Schaffer
    Keywords: Lipotoxicity, cardiomyopathy, myopathy, fatty acids, triglycerides
  • MAIN CLINICAL ARTICLE
    The metabolic syndrome
    Bernhard O. Boehm and Stephan Schiekofer
    Keywords: Diabetes, hyperglycemia, dyslipidemia, pleiotropic effects, lifestyle modification, metabolic syndrome
  • METABOLIC IMAGING
    Metabolic imaging in the metabolic syndrome
    Linda Peterson
    Keywords: Metabolic syndrome, metabolism, positron emission tomography, heart, magnetic resonance spectroscopy
  • NEW THERAPEUTIC APPROACHES
    Metabolic syndrome: pharmacological treatment
    Pieter A. van Zwieten and Frans Visser
    Keywords: Metabolic syndrome, insulin resistance, antihypertensive drugs, diabetes mellitus (type 2), obesity, hyperlipidemia
  • FOCUS ON VASTAREL MR
    Effect of selective 3-ketoacyl coenzyme A thiolase inhibition on glucose metabolism in cardiac patients
    Gabriele Fragasso et al.
    Keywords: Trimetazidine, diabetes, glucose metabolism, left ventricular function, endothelial function, 3-ketoacyl coenzyme A thiolase inhibition
  • CASE REPORT
    Hypercalcemia and the cardiovascular system
    V.J. Karthikeyan et al.
    Keywords: Hypercalcemia, hyperparathyroidism, hypertension, heart failure, complete heart block, renal failure
  • REFRESHER CORNER
    What is insulin resistance?
    Gurushankar Govindarajan et al.
    Keywords: Hypertension, polycystic ovary disease, cardiometabolic syndrome, diabetes mellitus, cardiovascular disease, renal disease
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 29, 2005, Bypass surgery for coronary artery disease: a vanishing treatment?

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  • EDITORIAL
    Bypass surgery for coronary artery disease: a vanishing treatment?
    Frans Visser
  • BASIC ARTICLE
    Mechanism of cardiac damage associated with cardiac surgery
    David J. Chambers
  • MAIN CLINICAL ARTICLE
    Managing contractile dysfunction after cardiac surgery
    Armand R. Girbes and A. B. Johan Groeneveld
  • METABOLIC IMAGING
    Value of perioperative transesophageal echocardiography
    Otto Kamp
  • NEW THERAPEUTIC APPROACHES
    Metabolic interventions during cardiac surgery: focus on glucose–insulin–potassium
    Harry B. van Wezel
  • FOCUS ON VASTAREL MR
    Protective effects of trimetazidine before and after coronary artery bypass surgery
    Álvaro D.B. Bordalo
  • CASE REPORT
    Hibernating myocardium and coronary artery bypass surgery
    Ian Hunt and Tunde Ogunyiluka
  • REFRESHER CORNER
    Risk associated with cardiac surgery
    Christopher Blauth
  • FEATURED RESEARCH
    Abstracts and commentaries

Number 28, 2005, Sex and the Heart

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  • EDITORIAL
    Graham Jackson
  • BASIC ARTICLE
    Erectile dysfunction as an early indicator of cardiovascular and metabolic disease
    Kevin L. Billups
  • MAIN CLINICAL ARTICLE
    Managing sexual dysfunction in the cardiac patient
    Adolph M. Hutter Jr
  • NEW THERAPEUTIC APPROACHES
    Safety and efficacy of the medical treatment of erectile dysfunction
    Graham Jackson
  • FOCUS ON VASTAREL MR
    Efficacy and safety of trimetazidine and phosphodiesterase type-5 inhibitors
    Graham Jackson
  • CASE REPORT
    Erectile dysfunction as a marker of silent ischemia
    Michael Kirby
  • REFRESHER CORNER
    The hemodynamics of sex
    Ian Eardley
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 27, 2005, Metabolic approach in heart failure

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  • EDITORIAL
    Metabolic approach in heart failure
    Graham Jackson
  • BASIC ARTICLE
    Metabolic approach in heart failure: the rationale for metabolic interventions
    Gary D. Lopaschuk, William A. Stanley, Catharine C. Lopaschuk
  • MAIN CLINICAL ARTICLE
    The place of metabolic treatment
    Hanna Szwed
  • METABOLIC IMAGING
    Glucose–insulin–potassium infusion enhances myocardial wall motion in patients with chronic ischemic heart failure
    Lucas J. Klein, Linda (C.) M.C. van Campen, Thomas H. Marwick
  • NEW THERAPEUTIC APPROACHES
    Evidence of efficacy of metabolic agents
    Mario Marzilli, Silvia Affinito
  • FOCUS ON VASTAREL MR
    Vastarel MR: an innovative metabolic approach to ischemic heart failure
    Elena Louette
  • CASE REPORT
    An elderly lady with angina and heart failure—successful response to trimetazidine
    Graham Jackson
  • REFRESHER CORNER
    Metabolic link between ischemia and cardiac dysfunction
    William C. Stanley
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    Gary Lopaschuk

Number 26, 2005, Cardiovascular effects of exercise

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  • EDITORIAL
    Cardiovascular effects of exercise
    M. Marzilli
  • BASIC ARTICLE
    Adaptive and maladaptive cardiac hypertrophy
    M. F. Allard
  • MAIN CLINICAL ARTICLE
    Risks and benefits of exercise in cardiac disease
    N. Smart, T. H. Marwick
  • METABOLIC IMAGING
    Imaging: hypertrophic cardiomyopathy and athlete’s heart
    I. Paetsch, E. Nagel
  • NEW THERAPEUTIC APPROACHES
    Constructing an exercise program
    A. A. McLeod
  • FOCUS ON VASTAREL MR
    New therapeutic approach in chronic heart failure: metabolic intervention with trimetazidine
    H. S. Sisakyan
  • CASE REPORT
    Sustained benefit of trimetazidine adjunct to standard treatment in severe heart failure
    M. Marzilli
  • REFRESHER CORNER
    Cardiac adaptation to exercise
    H. Kuipers
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    G. Lopaschuk

Number 25, 2004, Heart failure in diabetes

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  • EDITORIAL
    Heart failure in diabetes
    M. Marber
  • BASIC ARTICLE
    Metabolic derangements in insulin resistance
    D. Feuvray
  • MAIN CLINICAL ARTICLE
    Management of chronic heart failure in patients with type 2 diabetes: the importance of an integrated approach
    V. A. Ezzat, M. T. Kearney
  • METABOLIC IMAGING
    Metabolic imaging and diabetes
    J. Knuuti
  • NEW THERAPEUTIC APPROACHES
    Novel approaches in the treatment of diabetes mellitus diabetic cardiomyopathy
    R. Belardinelli
  • FOCUS ON VASTAREL MR
    Ischemic heart disease and diabetes: rationale for a metabolic approach, and clinical evidence
    P. Meurin, T. He´nane
  • CASE REPORT
    Diabetes and heart failure
    S. Wheatcroft
  • REFRESHER CORNER
    Peroxisome proliferator-activated receptors and the cardiovascular system
    L. A. Nikolaidis, T. B. Levine
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    G. Lopaschuk

Number 24, 2004, Angina Pectoris

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  • EDITORIAL
    What’s new in angina pectoris?
    F. C. Visser
  • BASIC ARTICLE
    Molecular mechanisms of cardiac ischemic pain
    F. Crea
  • MAIN CLINICAL ARTICLE
    Risk stratification in chronic stable angina
    M. Marzilli
  • METABOLIC IMAGING
    Imaging the coronary vasculature using multislice computed tomography
    N. R. Mollet et al
  • NEW THERAPEUTIC APPROACHES
    New developments in the drug treatment of stable angina pectoris
    P. A. van Zwieten, F. C. Visser
  • FOCUS ON VASTAREL MR
    Vastarel MR: effective and safe for coronary patients treated with a phosphodiesterase type 5 inhibitor
    G. Rosano
  • CASE REPORT
    Neurogenic induced myocardial dysfunction
    I. A. C. van der Bilt, F. C. Visser
  • REFRESHER CORNER
    Assessment of collateral circulation
    Gerald S. Werner
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    G. Lopaschuk

Number 23, 2004, Acute coronary Syndromes

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  • EDITORIAL
    Metabolic interventions for acute coronary syndromes?
    F. C. Visser
  • BASIC ARTICLE
    Alterations in energy metabolism in acute coronary syndromes
    A. Noga, J. R. B Dyck, G. Lopaschuk
  • MAIN CLINICAL ARTICLE
    Risk stratification and outcome in non-ST-segment elevation in acute coronary syndromes R. Malhotra and M. S. Sabatine
  • METABOLIC IMAGING
    Glucose and fatty acid changes in acute coronary syndromes
    A-S. E. Hamby¨e, P. R. Franken
  • NEW THERAPEUTIC APPROACHES
    Guidelines and metabolic approach to acute coronary syndrome
    F. R. Eberli
  • FOCUS ON VASTAREL MR
    Metabolic cardioprotection in patients undergoing revascularization
    P. Meurin and T. He´nane
  • CASE REPORT
    Beneficial role of metabolic treatment in a patient with refractory angina after an
    acute coronary syndrome
    H. Szwed
  • REFRESHER CORNER
    Metabolic changes in ischemia and myocardial infarction
    W. C. Stanley
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY
    G. Lopaschuk

Number 22, 2004, Endothelial Dysfunction

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  • EDITORIAL
    Endothelial dysfunction
    G. Jackson
  • BASIC ARTICLE
    Endothelial function and dysfunction
    P. Vanhoutte
  • MAIN CLINICAL ARTICLE
    Clinical expression of endothelial dysfunction
    W. Dunn, A. Lerman, V. Shah
  • METABOLIC IMAGING
    Imaging of coronary endothelial dysfunction by use of positron emission tomography
    F. M. Bengel
  • NEW THERAPEUTIC APPROACHES
    Treatment options for endothelial dysfunction
    S. von Haehling
  • FOCUS ON VASTAREL MR
    Evidence-based efficacy of Vastarel in patients with ischemic cardiomyopathy
    H. C. Tan
  • CASE REPORT
    Imaging of endothelial dysfunction
    P. Knaapen, W. G. van Dockum
  • REFRESHER CORNER
    Regulation of coronary perfusion
    S. J. Fraser, D. E. Newby, N. G. Uren
  • FEATURED RESEARCH
    Abstracts and commentaries
  • GLOSSARY