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- EDITORIAL
Acute coronary syndromes: changing face
M. Marzilli
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ORIGINAL ARTICLES
The changing face of acute coronary syndromes
S. Al Yaseen, A. Al Badri, J. Wei, C.Shufelt, N. Bairey Merz
Keywords: acute coronary syndrome; non–ST-segment elevation myocardial infarction; stable ischemic heart disease; sex differences; ST-segment elevation myocardial infarction
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ORIGINAL ARTICLES
Acute coronary syndrome without coronary obstructions: diagnosis and treatment
G. Niccoli, G. Scalone, F. Crea
Keywords: acute myocardial infarction; microcirculation; no obstructive coronary atherosclerosis
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ORIGINAL ARTICLES
Does unstable angina still exist?
C. A. Rambarat, I. Y. Elgendy, C. J. Pepine
Keywords: myocardial infarction; troponin; unstable angina
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ORIGINAL ARTICLES
Acute coronary syndrome: the illusion of treatment!
M. Marzilli
Keywords: acute coronary syndrome; percutaneous coronary intervention; therapeutic illusion
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ORIGINAL ARTICLES
Focus on trimetazidine in acute coronary syndrome
L. H. W. Gowdak
Keywords: arrhythmia; myocardial infarction; prognosis; treatment; trimetazidine
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CASE REPORT
From atropine eye drops to takotsubo syndrome in an 89-year-old lady
M. C. Scali, M. Marzilli
Keywords: acute microvascular dysfunction; atropine; takotsubo syndrome
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REFRESHER CORNER
Cardiac energy metabolism in mild and severe ischemia
G. D. Lopaschuk
Keywords: fatty acid oxidation; glucose oxidation; glycolysis
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HOT TOPICS
False positive troponins
M. Marber
Keywords: acute coronary syndrome; biomarker; necrosis; troponin
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Heart failure in real life
M. Marber
Read the editorial -
ORIGINAL ARTICLES
Assessing the breathless patient
M. R. Cowie
Keywords: diagnosis, heart failure; natriuretic peptide
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ORIGINAL ARTICLES
Heart failure with mid-range EF (HFmrEF): a mildly reduced EF does not imply a mild
disease
C. Tschöpe, B. Pieske
Keywords: diagnostic, HFmrEF, pathophysiology, treatment
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ORIGINAL ARTICLES
Renal function in acute heart failure: what can go wrong and what we can do about it
S. R. Goldsmith
Keywords: acute heart failure, kidney, afterload/preload
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ORIGINAL ARTICLES
Preventing heart failure hospital readmissions: challenges and opportunities
B. Ziaeian, G. C. Fonarow
Keywords: heart failure, prevention, process measures, quality of care, readmission
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ORIGINAL ARTICLES
Clinical benefits of trimetazidine in heart failure
G. M. C. Rosano
Keywords: cardiac energy metabolism, heart failure, trimetazidine
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CASE REPORT
Team-based management to improve real-world outcomes in heart failure
M. Ryan
Keywords: Team-based management in heart failure
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REFRESHER CORNER
Cellular metabolic and structural changes in heart failure
G. D. Lopaschuk
Keywords: apoptosis, autophagy, excitation-contraction coupling, mitochondria, mitofission, mitofusion,mitophagy
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HOT TOPICS
Identifying heart failure in the emergency room
M. C. Scali
Keywords: B-line, emergency room, heart failure, lung comet
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Diabetes: getting to the heart of the matter.
G. D. Lopaschuk
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ORIGINAL ARTICLES
Diabetes: the cost of globalization
P. M. Nilsson, L. Bennet
Keywords: costs, diabetes, global, lifestyle, migration, obesity
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ORIGINAL ARTICLES
Better glycemic control and cardiovascular outcomes
G. D. Lopaschuk
Keywords: antihyperglycemic agent, cardiovascular outcome, heart failure, type 2 diabetes mellitus
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ORIGINAL ARTICLES
Treating myocardial ischemia in diabetics: drugs, surgery, and stents
R. Belardinelli
Keywords: chronic angina, diabetes mellitus, therapeutic strategy
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ORIGINAL ARTICLES
Early detection of left ventricular dysfunction in diabetes
D. Y. Leung, M. Leung
Keywords: cardiomyopathy, diabetes, echocardiography
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ORIGINAL ARTICLES
Clinical benefits of targeting cardiac cells directly with trimetazidine in patients with coronary disease and diabetes
G. Fragasso, G. Anastasia, G. Monaca, G. Pinto
Keywords: CAD, diabetes, myocardial metabolism, trimetazidine
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CASE REPORT
Managing chest pain in a diabetic patient
M. C. Scali
Keywords: B-lines, risk, stress-echo
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REFRESHER CORNER
Cardiac energy metabolism in diabetes
K. L. Ho, J. R. Ussher
Keywords: energy metabolism, fatty acid oxidation, glucose oxidation, type 1 diabetes, type 2 diabetes
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HOT TOPICS
Cardiovascular diseases and diabetes: causes and cures
J. E. Salles
Keywords:
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Living with pain
L. H. W. Gowdak
Read the editorial -
ORIGINAL ARTICLES
Refractory angina or inappropriate antianginal therapy?
A. Huqi, M. Marzilli
Keywords: CAD, guideline-directed medical therapy, persistent angina
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ORIGINAL ARTICLES
Prevalence of refractory angina in clinical practice
L. H. W. Gowdak
Keywords: optimal medical therapy, prevalence, refractory angina
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ORIGINAL ARTICLES
Prognostic implications of refractory angina
P. G. Steg
Keywords: angina, ischemia, prognosis
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ORIGINAL ARTICLES
Nonpharmacological approaches to refractory angina.
R. Cheng, T. D. Henry
Keywords: enhanced external counterpulsation, neuromodulation, PCI, refractory angina
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ORIGINAL ARTICLES
Clinical benefits of treating angina directly at the cardiac cell level with
trimetazidine.
I. Milinković, A. J. Coats, G. Rosano, Y. Lopatin, P. M. Seferović
Keywords: antianginal, cardiomyocyte, trimetazidine
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CASE REPORT
The role of optimal medical therapy in patients with refractory angina
L. H. W. Gowdak
Keywords: angina, coronary artery disease, treatment
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REFRESHER CORNER
Estimating ischemic burden
V. Agarwal, M. F. Di Carli
Keywords: coronary flow reserve (CFR), ischemic burden, multimodality cardiac imaging
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HOT TOPICS
Errare humanum est, perseverare autem diabolicum
A. Huqi
Keywords: comparative effectiveness of noninvasive diagnostic strategies, coronary artery disease, ischemic heart disease, percutaneous coronary intervention
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
HFpEF, is it more than just the sum of its parts?
M. Marber
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ORIGINAL ARTICLES
Heart failure with preserved ejection fraction (HFpEF): a basic and clinical perspective.
A. Shah, P. C. Chowienczyk
Keywords: diastolic dysfunction, HFpEF, ventricular-vascular coupling
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ORIGINAL ARTICLES
How to diagnose heart failure with preserved ejection fraction.
T. H. Marwick
Keywords: diagnosis, diastolic dysfunction, heart failure with preserved ejection fraction
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ORIGINAL ARTICLES
Treatment of HFpEF: why we have no evidence.
M. Marber
Keywords: HFpEF, left ventricular ejection fraction
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ORIGINAL ARTICLES
Imaging fibrosis in heart failure with preserved ejection fraction.
A. N. Bhuva, R. Schofield, R. T. Lumbers, C. H. Manisty, J. C. Moon
Keywords: HFpEF, myocardial fibrosis, T1 mapping
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ORIGINAL ARTICLES
Trimetazidine in the new 2016 European guidelines on heart failure and beyond.
Y. Lopatin
Keywords: heart failure, guidelines, myocardial metabolism, trimetazidine
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CASE REPORT
HFpEF or just multiple comorbidities? The challenges of making a definitive diagnosis.
J. Webb
Keywords: cardiac magnetic resonance imaging, HFpEF, pressure-volume loop analysis
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REFRESHER CORNER
Heart failure with preserved ejection fraction–where is the problem: heart or arteries?
S. Ewen, M. Böhm
Keywords: chronic heart failure, ESC guidelines, heart failure with preserved ejection fraction
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HOT TOPICS
The failing heart: an engine operating on “bad” fuel.
V. Sequeira, J. van der Velden
Keywords: ADP elevation, cardiac contractility and energetics, cardiomyocyte contractile reserve, diastolic dysfunction
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Burning fat to increase metabolic rates size: myth or reality
Derek J. Hausenloy, MD, PhD, FACC, FESC
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ORIGINAL ARTICLES
Reperfusion – the good, the bad, and the ugly
Gerd Heusch, FACC, FESC, FRCP
Institute for Pathophysiology, West German Heart and Vascular Center,
University of Essen Medical School, Essen, Germany
Keywords: cardioprotection, myocardial ischemia, reperfusion
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ORIGINAL ARTICLES
Mechanical interventions to reduce myocardial infarct size
Michael Rahbek Schmidt, MD, PhD; Nichlas Riise Jespersen, MD; Hans Erik Bøtker, MD, PhD, DMSc
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
Keywords: ischemic preconditioning, myocardial infarction, reperfusion injury
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ORIGINAL ARTICLES
How to measure myocardial infarct size by cardiac magnetic resonance imaging
David Corcoran, BMedSci MRCP; Colin Berry, PhD, FACC, FESC, FRCP
BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow
Golden Jubilee National Hospital, Clydebank, UK
Keywords: acute myocardial infarction, CMR imaging, infarct size
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ORIGINAL ARTICLES
Pharmacological agents for reducing myocardial infarct size in ST-segment elevation myocardial infarction
Thomas Bochaton, MD; François Derimay, MD; Michel Ovize, MD, PhD
Louis Pradel Hospital, Cardiovascular Functional Exploration Service,
Clinical Investigation Center & UMR1060 (CarMeN), Claude Bernard University Lyon 1, Lyon, France
Keywords: ischemia-reperfusion, ST-segment elevation myocardial infarction, treatment of reperfusion injury
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ORIGINAL ARTICLES
The cardioprotective effects of trimetazidine
Petr Widimsky, MD, DrSc, FESC, FACC
Cardiocenter, Third Faculty of Medicine, Charles University Prague, Czech Republic
Keywords: angina, cardioprotection; trimetazidine
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CASE REPORT
Assessing myocardial salvage in reperfused STEMI patients by hybrid cardiac PET-MR imaging
Heerajnarain Bulluck, MBBS, MRCP
The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK;
The National Institute of Health Research University College London Hospitals Biomedical Research Center, UK
Keywords: myocardial salvage, PET-MR, ST-segment elevation myocardial infarction
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REFRESHER CORNER
Metabolic changes in the acutely ischemic heart
Gary D. Lopaschuk, PhD
Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Keywords: glycolysis; ischemia, reperfusion
glycolysis; ischemia, reperfusion
HOT TOPICS
Reducing myocardial infarct size by remote ischemic conditioning
Luciano Candilio, MD(Res)
The Hatter Cardiovascular Institute, University College London, London, UK
Keywords: cardioprotection, myocardial infarction, remote ischemic conditioning
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Burning fat to increase metabolic rates
G. D. Lopaschuk
Read the editorial -
ORIGINAL ARTICLES
Brown adipose tissue and the genetics of obesity
Ande Satyanarayana, PhD
Department of Biochemistry and Molecular Biology, Molecular Oncology & Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia, USA
Keywords: beige cells, brown fat, genetic mouse models, oxidative metabolism, PGC1α, thermogenesis; UCP1
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ORIGINAL ARTICLES
Integrated control of brown adipose tissue
Emanuele Marzetti, MD, PhD1; Emanuela D’Angelo, MD1; Giulia Savera, BS1; Christiaan Leeuwenburgh, PhD2; Riccardo Calvani, PhD1
1Department of Geriatrics, Neurosciences and Orthopedics, Teaching Hospital “Agostino Gemelli,” Rome, Italy 2Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, USA
Keywords: adiposity, beige cells, diabetes mellitus, energy metabolism, inflammation, mitochondrial respiration, positron emission tomography (PET), sympathomimetics, weight loss
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ORIGINAL ARTICLES
Assessing brown adipose tissue in humans
Yu-Shin Ding, PhD New York University School of Medicine, Departments of Radiology and Psychiatry, New York, NY, USA
Keywords: brown adipose tissue, [11C]MRB, obesity, norepinephrine transporter, positron emission tomography (PET), sympathetic nervous system
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ORIGINAL ARTICLES
Brown adipose tissue as a potential therapeutic target in obesity therapy
Niels Jessen, MD, PhD Research Laboratory for Biochemical Pathology, Department for Clinical Medicine, Aarhus University, Denmark
Keywords: activators of thermogenesis, brown adipose tissue, obesity
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ORIGINAL ARTICLES
Benefits of trimetazidine (TMZ) in obese patients
Fausto J. Pinto, FESC, FACC Lisbon University Medical School, University of Lisbon, Lisbon, Portugal
Keywords: ischemic heart disease, obesity; trimetazidine
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CASE REPORT
Obesity and cardiovascular disease
Giacinta Guarini, MD, PhD Cardiovascular Medicine Division, Cardio Thoracic and Vascular Department, University of Pisa, Italy
Keywords: heart failure, obesity cardiomyopathy, obesity paradox
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REFRESHER CORNER
Uncoupling proteins as mediators of mitochondrial metabolic rates
Gary D. Lopaschuk, PhD Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
Keywords: mitochondria, mitochondrial membrane potential, thermogenesis, uncoupling protein 1, uncoupling protein 3
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HOT TOPICS
Will PCSK9 inhibitors stand up to statins till the end?
Alda Huqi, MD, PhD -
GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Cardiovascular events in diabetics: a great challenge and an unsolved problem
M. Marzilli
Read the editorial -
ORIGINAL ARTICLES
Diabetes and ischemia: similarities in cardiac energy metabolism
Tariq R. Altamimi, BSc and Gary D. Lopaschuk, PhD Cardiovascular Translational Science Institute and Department of Pediatrics, University of Alberta, Edmonton, Canada
Keywords: cardiac efficiency; diabetes; energy metabolism; heart; ischemia
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ORIGINAL ARTICLES
Stents, surgery, and optimal medical therapy in diabetes
Sonya N. Burgess, BSc, MBChB, FRACP; John K. French, BMedSc, MBChB, MSc, PhD Department of Cardiology, Liverpool Hospital and SWS Clinical School, The University of New South Wales, Sydney, NSW, Australia
Keywords: coronary artery bypass graft surgery, coronary heart disease, diabetes mellitus, optimal medical therapy, percutaneous coronary intervention
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ORIGINAL ARTICLES
Strain, perfusion, and fat in the diabetic heart
Grigorios Korosoglou1, Prof. Dr. med. and Hugo A. Katus2, Prof. Dr. med. 1GRN Hospital Weinheim, Weinheim, Germany 2Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Keywords: cardiac magnetic resonance, diabetes mellitus, diastolic dysfunction, echocardiography, late gadolinium enhancement, metabolism, myocardial perfusion, spectroscopy
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ORIGINAL ARTICLES
Is glycemic control relevant to cardiovascular clinical outcomes?
Angelo Avogaro, MD, PhD Department of Medicine, University of Padova, Padova, Italy
Keywords: cardiovascular disease, diabetes mellitus, microvascular complications, risk factors
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ORIGINAL ARTICLES
Trimetazidine effects on preventing cardiovascular events in diabetic patients
Luis Henrique Wolff Gowdak, MD, PhD, FESC Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
Keywords: diabetes; metabolism; myocardial ischemia; prognosis; trimetazidine
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CASE REPORT
Preventing cardiovascular events in diabetic patients: the case of the patient with poor distal coronary targets
Elisabetta Salutini, MD; Cristina Bianchi, MD; Roberto Miccoli, MD; Stefano Del Prato, MD, PhD Department of Clinical and Experimental Medicine, Section of Diabetes and Metabolic Diseases, University of Pisa, Italy
Keywords: coronary artery disease, diabetes, glucagon-like peptide-1 agonists, hypoglycemia, incretin, microvascular coronary dysfunction
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REFRESHER CORNER
Diabetic cardiomyopathy, does it exist?
Heiko Bugger, MD, PhD Heart Center Freiburg University, Freiburg, Germany
Keywords: diabetic cardiomyopathy, diabetes mellitus, heart
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HOT TOPICS
Antidiabetic treatment and cardiovascular events: all a matter of perspective!
Alda Huqi, MD
GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
The sensitivity versus specificity trade-off
Michael Marber, PhD, FRCP
Read the editorial
ORIGINAL ARTICLES
Using biomarkers to obtain mechanistic insight and guide management in acute coronary syndrome
Kai C. Wollert, MD
Keywords: acute coronary syndrome, acute myocardial infarction, biomarker, cardiac troponin, diagnosis, patient management, prognosis
ORIGINAL ARTICLES
Incorporating high-sensitivity cardiac troponin assays into clinical practice: these assays are your friend
Sara Love, PhD, Yader Sandoval, MD, Fred S. Apple, PhD
Keywords: biomarkers, cardiac troponin, diagnostic accuracy, high-sensitivity assays, myocardial infarction, outcomes
ORIGINAL ARTICLES
High biomarkers, but normal angiogram: what next?
Sebastiaan C. A. M. Bekkers, MD, PhD, Martijn W. Smulders, MD
Keywords: acute myocardial infarction, angiography, cardiovascular magnetic resonance imaging, computed tomography, nonobstructed coronary arteries, normal coronary arteries
ORIGINAL ARTICLES
What can we learn from metabolomics?
Ferheen Baig, MSc, BSc, Manuel Mayr, MD, PhD
Keywords: biomarker, cardiovascular, diabetes, lipidomics, metabolomics
ORIGINAL ARTICLES
Trimetazidine effects on cardiac biomarkers in acute coronary syndrome
Dr Jamshed Jal Dalal, MD, PhD
Keywords: acute coronary syndrome, cardiac biomarker, metabolic management, trimetazidine
CASE REPORT
Elevated cardiac troponin in a patient with coronary artery disease: why look harder?
Annette Maznyczka, BSc, MBChB, MRCP, Niharika Varma, BSc, MBBS, Lucy Foote, MBBS, Rupert Williams,
BSc, MBChB, MRCP, David D’Cruz, MD, FRCP, Valentina O. Puntmann, MD, PhD, MRCP
Keywords: chest pain, magnetic resonance imaging, systemic lupus erythematosus, troponin
REFRESHER CORNER
Defining acute myocardial infarction
Kai M. Eggers, MD, PhD
Keywords: definition criteria, diagnosis, myocardial infarction, troponin
HOT TOPICS
Metabolic markers in predicting acute cardiovascular events
Alda Huqi, MD
GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Hormones and the heart
G. Jackson
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ORIGINAL ARTICLES
Thyroid, aldosterone, and cardiovascular disease
C. Vlachopoulos, D. Terentes-Printzios
Keywords: aldosterone, cardiovascular disease, heart failure, hormone, thyroid
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ORIGINAL ARTICLES
Testosterone and cardiovascular disease
T. Hugh Jones
Keywords: cardiovascular, diabetes, heart, testosterone
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ORIGINAL ARTICLES
Measuring myocardial salvage: hormone cardioprotection
D. J. Hausenloy
Keywords: acute myocardial infarction, cardiac MRI, cardioprotection, myocardial reperfusion injury, myocardial salvage, PET/MRI
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ORIGINAL ARTICLES
Testosterone and the heart
C. C. K. Ho, H. M. Tan
Keywords: cardiovascular, metabolic syndrome, testosterone
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ORIGINAL ARTICLES
Effects of trimetazidine on hormones and the heart
V. Sansoy, K. Kılıçkesmez
Keywords: angina pectoris, cardiac metabolism, coronary artery disease, heart failure, natriuretic peptides
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CASE REPORT
Erectile dysfunction and lower urinary tract symptoms should trigger a metabolic
screen and cardiovascular risk estimation
M. Kirby
Keywords: cardiovascular disease, erectile dysfunction, lower urinary tract symptoms, metabolic syndrome, lifestyle
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REFRESHER CORNER
Evaluation of metabolic syndrome and male sexual dysfunction
J. J. Heidelbaugh, M. M. Miner
Keywords: cardiometabolic risk, erectile dysfunction, male sexual dysfunction, metabolic syndrome
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HOT TOPICS
Testosterone replacement therapy: cardiovascular benefits and possible risks
G. Hackett
Keywords: cardiovascular disease, elderly, European Male Ageing Study, hypogonadism, men, testosterone, testosterone deficiency syndrome
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
The rapid emergence of microRNAs as a therapeutic target to treat cardiovascular disease
G. D. Lopaschuk
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ORIGINAL ARTICLES
MicroRNA therapeutics for cardiovascular disease
E. van Rooij
Keywords: anti-miR, cardiovascular disease, microRNA; miRNA mimic, therapeutics
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ORIGINAL ARTICLES
Targeting microRNAs to promote cardiac repair and cardiomyocyte proliferation as a potential regenerative therapeutic approach
P. Jakob, U. Landmesser
Keywords: dyspnea; exercise, heart failure, skeletal musculature
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ORIGINAL ARTICLES
Evaluation of microRNAs by molecular imaging for novel diagnostics and therapeutics
W. Kloos, A. Keller, H. A. Katus, B. Meder
Keywords: biomarker, cardiovascular disease, microRNA, molecular imaging, therapeutic target
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ORIGINAL ARTICLES
The therapeutic potential of microRNAs in heart and vascular diseases
A. Zampetaki, B. Fanshawe, M. Mayr
Keywords: cardiovascular disease, microRNA, therapeutic application
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ORIGINAL ARTICLES
Nonmetabolic effects of trimetazidine and ventricular remodeling: role in regulatory gene expression
P. Di Napoli
Keywords: heart failure, mRNA, remodeling, trimetazidine
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CLINICAL APPLICATION
MicroRNA therapy of heart failure
L. R. Rodino-Klapac
Keywords: antagomiRs, biomarkers, heart failure, microRNAs, miR mimics
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REFRESHER CORNER
What are microRNAs?
T. Thum
Keywords: cardiac remodeling, cardiovascular disease, heart failure, microRNA
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HOT TOPICS
MicroRNAs as therapeutics for heart disease
J. R. Ussher
Keywords: cardiovascular disease, heart, heart failure, ischemic heart disease, microRNA, pulmonary arterial hypertension
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GLOSSARY
G. D. Lopaschuk
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- EDITORIAL
Heart failure: a cardiac or a systemic disease?
M. Marzilli
Read the editorial -
ORIGINAL ARTICLES
Heart and muscle, cut from the same striated cloth
S. von Haehling
Keywords: Heart failure, skeletal muscle, wasting, cachexia
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ORIGINAL ARTICLES
The symptoms of heart failure
M. Marzilli
Keywords: Dyspnea, exercise, heart failure, skeletal musculature
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ORIGINAL ARTICLES
Imaging of skeletal muscle metabolism in heart failure
P. Iozzo
Keywords: Exercise, oxidative metabolism, insulin resistance, positron emission tomography, magnetic resonance imaging, muscle composition
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ORIGINAL ARTICLES
Benefits of exercise training for the failing heart
R. Belardinelli
Keywords: Exercise training, chronic heart failure, outcome
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ORIGINAL ARTICLES
Effects on global metabolism by regulation of substrate utilization in heart failure
F. Loiacono, C. Silipigni, M. Pagnesi, G. Fragasso
Keywords: heart failure, trimetazidine, left ventricular function, global metabolism, diabetes
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CASE REPORT
Skeletal muscle myopathy in advanced heart failure: a case report
F. L. Dini, M. C. Scali, A. Simioniuc
Keywords: Heart Failure, Echocardiography, Cardiopulmonary Exercise Test, Skeletal Muscle myopathy, Cardiac Output
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REFRESHER CORNER
How to interpret cardiopulmonary exercise tests
M. Guazzi
Keywords: cardiopulmonary exercise, oxygen consumption, ventilation inefficiency
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HOT TOPICS
The “skeletal muscle—fat” interplay in heart failure
A. Huqi
Keywords: heart failure, obesity, skeletal muscle, obesity paradox
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GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
EAT your heart out!
Michael Marber
Read the editorial -
ORIGINAL ARTICLES
Nutrient signaling and cardiovascular aging
Anna Planavila, Francesc Villarroya, Manlio Vinciguerra
Keywords: Aging, cardiac hypertrophy, cardiomyocytes, cardiomyopathy, cell signaling, growth factors, heart, laminin, mice models, nutrients
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ORIGINAL ARTICLES
Does diet alter cardiovascular risk?
Ramon Estruch, Gemma Chiva-Blanch
Keywords: Atherosclerosis, cardiovascular disease, cardiovascular risk, diet, infl ammation, Mediterranean diet, olive oil, polyphenols, salt, vegetables, wine
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ORIGINAL ARTICLES
Epicardial adipose tissue: a simple marker of obesity or a complex mediator of cardiovascular disease?
Ronak Rajani
Keywords: Atherosclerosis, cardiovascular disease, epicardial adipose tissue, pathophysiology
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ORIGINAL ARTICLES
Gut microbes and cardiometabolic risk
Max Nieuwdorp
Keywords: Cardiovascular disease, gut microbiota, insulin resistance, obesity
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ORIGINAL ARTICLES
Focus on trimetazidine: effects on diet and the heart
Roberto Ferrari
Keywords: Adenosine triphosphate, angina, ATP, ATP/O2, β-oxidation, cardiac metabolism, fatty acid oxidation, ischemia, trimetazidine
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CASE REPORT
Resolution of metabolic syndrome after bariatric surgery: a case report
Rahul K. Mukherjee
Keywords: Angina, breathlessness, diet, gastric bypass, metabolic syndrome, obesity
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REFRESHER CORNER
Basic food composition: is it just sugar and fat?
Thomas A. B. Sanders
Keywords: Blood pressure, cardiovascular risk, fat, salt, sugar
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HOT TOPICS
The effects of bariatric surgery on the heart
Oliver J. Rider -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Myocarditis
Graham Jackson
Read the editorial -
BASIC ARTICLE
Myocarditis: the causes
Uwe Külh
Keywords: Autoimmunity, heart failure, inflammatory cardiomyopathy, myocarditis virus
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MAIN CLINICAL ARTICLE
Management of myocarditis
Chantal El Amm, Leslie T. Cooper
Keywords: Endomiocardial biopsy, heart failure, myocarditis
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METABOLIC IMAGING
Differentiating infarction from myocarditis
Eduardo Pozo, Javier Sanz
Keywords: Cardiac imaging techniques, cardiac magnetic resonance, differential diagnosis, myocardial infarction, myocarditis
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NEW THERAPEUTIC APPROACHES
Immunosuppresive therapy in virus-netagive inflammatory cardiomyopathy
Andrea Frustaci, Cristina Chimenti
Keywords: Heart failure, immunosuppressive therapy, myocarditis, recovery and function, viruses
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FOCUS ON
Metabolic remodeling as a target preventing myocardial dysfunction: focus on trimetazidine
Alexander N. Parkhomenko, Olga Gurjeva
Keywords: Cardiomyopathy, ischemia, metabolic remodeling, reperfusion, trimetazidine
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CASE REPORT
Multimodality imaging of Churg-Strauss myocarditis
Amit Sud, Roberta L. Brum, Kelly Victor, Panagiotis Koudounis, Gerald S. Carr-Vhite, Ronak Rajani
Keywords: Cardiac magnetic resonance, Churg-Strauss syndrome, echocardiography, eosinophilic granulomatosis polyangiitis, myocarditis
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REFRESHER CORNER
Myocarditis: inflammatory and endocrine causes
Alida L.P. Caforio
Keywords: Autoimmunity, diagnosis, dilated cardiomyopathy, endomyocardial biopsy, myocarditis
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HOT TOPICS
Takotsubo cardiomyopathy: a possible metabolic disorder
Mehmood Zeb, Bushra Naheed, Fahd Irshad, Tim Edwards, Ibrahim M. Ali, Fraser Witherow
Keywords: Takotsubo cardiomyopathy, transient LV apical ballooning, neurogenic stunned myocardium, ampulla cardiomyopathy, stress induced cardiomyopathy, broken heart syndrome, acute catecholamine cardiomyopathy
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GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
The metabolic contribution to heart failure
Gary D. Lopaschuk
Read the editorial -
ORIGINAL ARTICLES
The metabolic basis for the obesity paradox in heart failure
Stephan von Haehling
Keywords: Heart failure, muscle, obesity, obesity paradox
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ORIGINAL ARTICLES
Is chronic heart failure a reversible metabolic syndrome?
J. Eduardo Rame
Keywords: Cachexia, cardiac metabolism, chronic heart failure, insulin resistance
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ORIGINAL ARTICLES
Imaging metabolism and perfusion in patients with diabetes and heart failure
Patricia Iozzo, Maria Angela Guzzardi
Keywords: Cardiac fat, intervention, fatty acid oxidation, magnetic resonance spectroscopy, myocardial insulin resistance, positron emission tomography
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ORIGINAL ARTICLES
Inhibition of fatty acid oxidation as an approach to treat diastolic heart failure
John R. Ussher, Jagdip S. Jaswal
Keywords: Cardiac energetics, diastolic heart failure, diastolic dysfunction, fatty acid oxidation
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ORIGINAL ARTICLES
Use of trimetazidine to treat diabetes patients with heart failure
Rui Yan, Dengfeng Gao
Keywords: Energy metabolism, heart failure, trimetazidine
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CASE REPORT
Dramatic loss of weight in an obese patient with heart failure:
a mighty heart in a big man
Vitantonio Di Bello, Lorenzo Conte, Iacopo Fabiani, Valentina Barletta, Letizia Pieruzzi,
Giovanna Scartabelli, Ferruccio Santini
Keywords: Echocardiography, heart failure, natriuretic peptides, obesity
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REFRESHER CORNER
Energy metabolic changes in the diabetic heart
Lionel H. Opie
Keywords: Fatty acid oxidation, hyperglycemia, insulin resistance, metabolic syndrome
-
HOT TOPICS
Irisin, a novel myokine: potential role in obesity and diabetes
Andrew G. Swick
Keywords: Brown adipose tissue,energy expenditure,irisin,myokine
-
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Inflammation in atherosclerosis: casualty or causality?
M. Marber
Read the editorial -
ORIGINAL ARTICLES
Macrophages: cause or cure in atherosclerosis?
M. Bennett
Keywords: Apoptosis, atherosclerosis, inflammation, macrophages
-
ORIGINAL ARTICLES
The role of inflammation in atherosclerosis:
what we have learned from clinical trials?
M. Al-Hawwas, J.-F. Tanguay
Keywords: Atherosclerosis, coronary artery disease, inflammation
-
ORIGINAL ARTICLES
Metabolic imaging: imaging plaques
F. R. Joshi, M. Chowdhury, J. H. F. Rudd
Keywords: Atherosclerosis, fluorodeoxyglucose, inflammation, non invasive imaging
-
ORIGINAL ARTICLES
Secretory phospholipase: a potential target for cardiovascular therapies
S. J. Nicholls, M. Duong
Keywords: Cardiovascular disease, inflammation, risk factor, sPLA2
-
ORIGINAL ARTICLES
Trimetazidine effects on oxidative damage
S. J. Hong
Keywords: Myocardial infarction, oxidative damage, trimetazidine
-
CASE REPORT
Psoriasis and risk of cardiovascular disease: case report and discussion
C. Maybury, C. H. Smith
Keywords: Psoriasis, inflammation, skin disease, cardiovascular disease, anti-TNF therapy
-
REFRESHER CORNER
Innate immunity: an integrated overview
S. G. Shaw
Keywords: C-type lectin receptors, innate immunity, NOD-like receptors, RIG-1-like receptors, Toll-like receptors
-
HOT TOPICS
Can infective agents be respectable etiopathogenetic factors for acute coronary syndromes?
A. Huqi
-
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Where is the resistance?
M. Marzilli
Read the editorial -
BASIC ARTICLE
Pressure drops along coronary vasculature
G. Guarini and M. Marzilli
Keywords: Coronary microvasculature, coronary resistance, coronary stenosis, perfusion pressure
-
MAIN CLINICAL ARTICLE
Integrated control of coronary microvascular tone: in series mechanisms for a differential regulation of flow and capillary pressure
G. Sambuceti, S. Capitanio and C. Marini
Keywords: Atherosclerosis, coronary blood flow, coronary microcirculation, endothelium, 1-25-dihydroxyvitamin D, parathyroid hormone
-
METABOLIC IMAGING
Magnetic resonance imaging perfusion to assess transmural flow distribution
A. Chiribiri and E. Nagel
Keywords: Adenosine, coronary disease, fractional flow reserve, high-resolution quantification, magnetic resonance imaging, perfusion
-
NEW THERAPEUTIC APPROACHES
Do we need to lower coronary resistances?
B. I. Lévy
Keywords: Coronary reserve, coronary flow, capillary density, hemorheology, myocardial perfusion, pharmacology, vasodilatation
-
FOCUS ON TRIMETAZIDINE (VASTAREL® MR)
Trimetazidine effects on restoring endothelial function
K.-H. Park
Keywords: Endothelium, nitric oxide, oxidative stress, trimetazidine
-
CASE REPORT
“Resistance in the cath lab”: the utility of hyperemic stenosis resistance in the functional assessment of coronary artery disease
K. De Silva and D. Perera
Keywords: Fractional flow reserve, functional assessment, hyperemic stenosis resistance, microvascular resistance
-
REFRESHER CORNER
Impact of myocardial function on perfusion
G. Guarini
Keywords: Coronary autoregulation, coronary metabolic dilation, coronary microcirculation, myocardial function, myocardial perfusion
-
HOT TOPICS
Coronary arterial system: pathophysiological hints from large clinical trials
A. Huqi
-
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Re-evaluating revascularization
M. Marber
Read the editorial -
BASIC ARTICLE
Coronary flow and physiology beyond the stenosis
M. Siebes
Keywords: Control of coronary blood flow, coronary artery stenosis, coronary microcirculation, myocardial perfusion
-
MAIN CLINICAL ARTICLE
Does revascularization work?
M. S. Sidhu and W. E. Boden
Keywords: Coronary artery disease, myocardial revascularization, optimal medical therapy, stable ischemic heart disease
-
METABOLIC IMAGING
Imaging myocardial edema
D. P. O’Regan and S. A. Cook
Keywords: Acute myocardial infarction, cardiovascular magnetic resonance, myocardial salvage
-
NEW THERAPEUTIC APPROACHES
Angiogenic therapy: is it still viable?
C. Seiler
Keywords: Angiogenesis, arteriogenesis, collateral circulation, coronary circulation
-
FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
Metabolic cardiac protection is beneficial in patients undergoing coronary revascularization: is it necessary afterwards?
Y. Lopatin
Keywords: coronary artery bypass grafting (CABG), metabolic cardioprotection, percutaneous coronary intervention (PCI), trimetazidine
-
CASE REPORT
Coronary artery disease: two sides of the same coin
P. Capozza and G. Todiere
Keywords: Acute coronary syndrome, coronary angiography, fractional flow reserve
-
REFRESHER CORNER
History of coronary revascularization
S. B. King
Keywords: Coronary angioplasty, coronary artery bypass graft surgery, percutaneous coronary intervention, revascularization stenting
-
HOT TOPICS
Revascularization and optimal medical therapy: shattering new evidence
A. Huqi
-
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
The challenge of treating diastolic heart failure
G. D. Lopaschuk -
BASIC ARTICLE
Differentiating diastolic dysfunction from classic heart failure
J. S. Jaswal and J. R. Ussher
Keywords: Cardiac energetics, diabetic cardiomyopathy, diastolic dysfunction, heart failure, obesity
-
MAIN CLINICAL ARTICLE
Advances in the treatment of heart failure with preserved systolic function
K. J. Lyons and J. A. Ezekowitz
Keywords: Diastolic, drug therapy, heart failure, randomized controlled trials as topic
-
METABOLIC IMAGING
Diastolic dysfunction: improved understanding using emerging imaging techniques
F. L. Dini
Keywords: Diastolic function, left ventricular filling pressure, tissue Doppler imaging, strain analysis
-
NEW THERAPEUTIC APPROACHES
Metabolic therapy for heart failure including diastolic heart failure
N. Siddiqi, D. Dawson, A. Rudd and M. Frenneaux
Keywords: Cardiac energetics, cardiac metabolism, cardiomyopathy, heart failure, metabolic therapy
-
FOCUS ON TRIMETAZIDINE (Vastarel ® MR)
New pharmacological targets in the treatment of heart failure:
inhibition of free fatty oxidation by trimetazidine
N. Signoretta, L. Alberti, L. Lauretta, B. Demarchi, F. Loiacono, A. Margonato and G. Fragasso
Keywords: Carnitine palmitoyl transferase I, free fatty acid inhibitors, heart failure, left ventricular function, metabolic therapy, myocardial metabolism, trimetazidine
-
CASE REPORT
Acute shortness of breath and chest tightness in an elderly patient:
clinical history tells it best!
A. Huqi
Keywords: Comorbidities, comprehensive evaluation, diastolic dysfunction, diastolic heart failure, non invasive assessment
-
REFRESHER CORNER
How the heart relaxes
N. Fillmore and G. D. Lopaschuk
Keywords: Calcium; diastole, sarcomere, sarcoplasmic reticulum
-
HOT TOPICS
The undisputed principles of myocardial ischemia!
A. Huqi -
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
The heart of an athlete
G. Jackson -
BASIC ARTICE
Physiological versus pathological left ventricular hypertrophy
T. Kotecha, K. Fox
Keywords: left ventricular hypertrophy, hypertrophic cardiomyopathy, athlete’s heart, echocardiography
-
MAIN CLINICAL ARTICLE
Clinical evaluation of the athlete
A. Cox, S. Sharma
Keywords: arrhythmias, athlete’s heart, clinical evaluation, physiological adaptations, sudden cardiac death
-
METABOLIC IMAGING
Athlete’s heart or hypertrophic cardiomyopathy
R.H. Fagard
Keywords: athlete’s heart, hypertrophic cardiomyopathy, echocardiography, endurance training, static training
-
NEW THERAPEUTIC APPROACHES
To train or not to train? That is the question
A.L. Baggish
Keywords: athlete’s heart, cardiomyopathy, exercise physiology, overuse injury
-
FOCUS ON TRIMETAZIDINE (Vastarel® MR)
The improvement of trimetazidine on exercise performance in ischemic
heart disease
Y. Chen
Keywords: trimetazidine (TMZ), ischemic heart disease (IHD), exercise capacity, exercise performance;quality of life (QOL), left ventricular ejection fraction (LVEF)
-
CASE REPORT
Life saving pre-participation athletic screening
M. Elmaghawry, A. Zorzi, M. Perazzolo Marra, D. Corrado
Keywords: arrhythmogenic right ventricular cardiomyopathy, electrocardiogram, pre-participation screening, implantable cardioverter defibrillator, sports cardiology
-
REFRESHER CORNER
Effects of performance-enhancing drugs on cardiac structure
and energy metabolism
J.R. Ussher, J.S. Jaswal
Keywords: performance-enhancing drugs, anabolic androgenic steroids, human growth hormone, left ventricular hypertrophy, cardiac energy metabolism
-
HOT TOPICS
Clinical assessment of revascularized patients
A. Huqi -
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Talking ‘omics
M. Marber -
BASIC ARTICLE
Proteomics and microRNA profiling in cardiac fibrosis
J. Barallobre-Barreiro, A. Didangelos, M. Mayr
Keywords: cardiac fibrosis, fibroblasts, proteomics, miRNAs
-
MAIN CLINICAL ARTICLE
Metabolomics in coronary heart disease
D. J. Grainger, D. E. Mosedale
Keywords: diagnostics, atherosclerosis, profiling, multivariate statistics
-
METABOLIC IMAGING
Dynamic nuclear polarization and MRI for the study of cardiac metabolism
T. R. Eykyn, R. Southworth, S. Kozerke
Keywords: dynamic nuclear polarization, MRI, cardiac metabolism, 13C
-
NEW THERAPEUTIC APPROACHES
Genomic prediction of individual drug response
L. Mestroni
Keywords: pharmacogenomics, genetic variation, cardiovascular genetics, drug response, heart failure
-
FOCUS ON TRIMETAZIDINE (Vastarel® MR)
Efficacy of trimetazidine: lessons from meta-analyses
J. P. Ribeiro
Keywords: coronary artery disease, angina, heart failure, left ventricular function, functional capacity
-
CASE REPORT
Assay what? The troponin masqueraders—a case report
J. O. Baker, K. De Silva
Keywords: acute myocardial infarction, cardiac troponin, assay interference, heterophile antibodies, delta change
-
REFRESHER CORNER
Fundamentals of genome-wide association studies
M. Mangino
Keywords: genome-wide association, complex disease, single nucleotide polymorphisms (SNP), linkage disequilibrium
-
HOT TOPICS
The struggles of translational medicine in ischemia-reperfusion injury
A. Huqi -
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Cardiac protection in acute cardiac syndrome
M. Marzilli -
BASIC ARTICLE
Magnitude and relevance of reperfusion injury
D. J. Hausenloy
Keywords: myocardial reperfusion injury, primary percutaneous coronary intervention (PPCI), ST-segment elevation myocardial infarction (STEMI)
-
MAIN CLINICAL ARTICLE
Pharmacological cardiac protection
E. Orsini, M. Marzilli, D. Morrone, P. Capozza, A. Huqi, F. L. Dini, and G. Guarini
Keywords: ischemia-reperfusion injury, cardioprotection, preconditioning, postconditioning, mitochondrial permeability transition pore, adenosine
-
METABOLIC IMAGING
Magnetic resonance imaging of the microcirculation in acute coronary syndromes
K. De Silva, J. Baker, A. Kidambi, D. Perera and S. Plein
Keywords: microvascular dysfunction, magnetic resonance imaging (MRI), acute coronary syndrome, myocardial infarction
-
NEW THERAPEUTIC APPROACHES
Postconditioning
M. Marzilli, D. Morrone and G. Guarini
Keywords: ischemia reperfusion injury, cardioprotection, post-conditioning, remote conditioning
-
FOCUS ON Vastarel® MR
Metabolic cardiac protection
G. Guarini
Keywords: cardiac ischemia, ischemia/reperfusion injury, cardioprotection, trimetazidine
-
CASE REPORT
Myocardial infarction with contemporary bivasal occlusion: one case, two fates
P. Capozza and M. Marzilli
Keywords: myocardial infarction, adenosine, cardioprotection, microcirculation
-
REFRESHER CORNER
Myocytes versus endothelial damage
F. L. Dini, E. Orsini, M. Marzilli and G. Guarini
Keywords: ischemic injury, reperfusion injury, endothelial damage, cardioprotection
-
HOT TOPICS
The heart failure and obesity paradox: would you suggest your patients gain weight?
A. Huqi -
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Energetics in heart disease
D. Feuvray -
BASIC ARTICLE
Myocardial energetics and efficiency
E. Aasum
Keywords: cardiac energy metabolism, oxygen consumption, mechano energetics, heart failure
-
MAIN CLINICAL ARTICLE
Modulation of cardiac energetics as a target in ischemic heart disease
H. Ashrafian
Keywords: cardiac energetics, ischemic heart disease, metabolic therapies, cardiac metabolism
-
METABOLIC IMAGING
Glucose metabolism as a marker of myocardial ischemia
P. G. Camici
Keywords: coronary artery disease, myocardial metabolism, myocardial ischemia, positron emission tomography.
-
NEW THERAPEUTIC APPROACHES
An expanded role for AMP kinase: self-renewal of the cardiomyocyte
K. Baskin and H. Taegtmeyer
Keywords: AMPK, protein degradation, cardiac metabolism
-
FOCUS ON TRIMETAZIDINE (Vastarel® MR)
Beneficial effects of trimetazidine (Vastarel® MR) in patients with chronic heart failure
G. Fragasso, L. Alberti and L. Lauretta
Keywords: systolic-dysfunction, heart failure, left ventricular function, metabolic therapy, energy expenditure
-
CASE REPORT
Myocardial power delivery is impaired in progressive left ventricular pump failure: a case report
F. L. Dini
Keywords: heart failure, dilated cardiomyopathy, echo stress
-
REFRESHER CORNER
Impact of fatty acid oxidation on cardiac efficiency
N. Fillmore and G. D. Lopaschuk
Keywords: fatty acid ß-oxidation, uncoupling proteins, mitochondrial thioesterase, glucose oxidation, glycolysis
-
HOT TOPICS
Statin therapy: reduction in cardiovascular events still pays in new-onset diabetes
A. Huqi -
GLOSSARY
G. D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Equality of care for the elderly
Graham Jackson -
BASIC ARTICLE
Energy metabolism in the aging heart
Jason R.B. Dyck, Miranda M.Y. Sung
Keywords: aging, myocardial metabolism, contractile dysfunction, mitochondria
-
MAIN CLINICAL ARTICLE
Managing angina in the elderly: the impact of comorbidities
Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Christodoulos Stefanadis
Keywords: elderly, coronary artery disease, angina; comorbidities
-
METABOLIC IMAGING
Cardiac computed tomography in the elderly: windows into a lifetime of exposure to cardiac risk
Gary R. Small, Benjamin J.W. Chow, Terrence D. Ruddy
Keywords: cardiac CT, coronary calcification, risk stratification, elderly
-
NEW THERAPEUTIC APPROACHES
Transcatheter aortic valve implantation in the elderly: current state of play
Aung Myat, Muhammed Zeeshan Khawaja, Hari Haran, Kaleab Asrress, Simon Redwood
Keywords: TAVI, aortic stenosis, transfemoral, transapical, stroke, surgical AVR
-
FOCUS ON VASTAREL® MR
Quality of life with trimetazidine
Giuseppe Marazzi
Keywords: ischemic cardiomyopathy, trimetazidine, quality of life
-
CASE REPORT
Metabolic approach to ischemic heart disease in the elderly
Cristiana Vitale
Keywords: elderly, ischemic heart disease, arterial peripheral disease, trimetazidine
-
REFRESHER CORNER
Improving the quality of sex life in the elderly
J.M. Tomlinson
Keywords: ageing, sex life, elderly, PDE5 inhibitors, hormone replacement therapy, retirement homes
-
HOT TOPICS
Medical therapy versus revascularization rounds: ischemic heart failure on focus
Alda Huqi -
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
The rising tide of cardiotoxicity associated with cancer chemotherapy
Gary D. Lopaschuk -
BASIC ARTICLE
Cardiotoxicity in cancer therapeutics
Christian Zuppinger
Keywords: cancer therapy, cardiotoxicity, anthracyclines, cell death, mitochondria
-
MAIN CLINICAL ARTICLE
Assessing and monitoring cardiac function in cancer patients
K. von Klemperer, K. Fox
Keywords: cancer, chemotherapy, heart failure, cardiotoxicity
-
METABOLIC IMAGING
Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer
Mukesh K. Pandey, Aditya Bansal, Timothy R. DeGrado
Keywords: PET, fatty acid oxidation, thia fatty acid, FTHA, FTP, FTO
-
NEW THERAPEUTIC APPROACHES
Metabolic modulation as a novel cancer treatment
Peter Dromparis, Gopinath Sutendra, Evangelos D. Michelakis
Keywords: cancer, metabolic, apoptosis, dichloroacetate, glycolysis
-
FOCUS ON VASTAREL® MR
Cancer and inhibition of fatty acid oxidation
Alda Huqi
Keywords: cancer, Warburg effect, metabolic modulation therapy, fatty acid oxidation
-
CASE REPORT
A case of multifactorial late left ventricular dysfunction after cancer treatment
Chiara Lestuzzi
Keywords: cardiotoxicity, radiotherapy, left ventricular dysfunction, Hodgkin’s disease, coronary artery disease, dyslipidemia
-
REFRESHER CORNER
The Warburg effect – aerobic glycolysis in proliferating cells
Jagdip S. Jaswal
Keywords: cellular proliferation, glycolysis, glucose oxidation, cellular biosynthesis
-
HOT TOPICS
Warfarin and dabigatran: an historical handover?
Alda Huqi
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- EDITORIAL
Changing epidemiology of ischemic heart disease
Mario Marzilli -
BASIC ARTICLE
Emerging patterns in IHD in developing countries
Raffaele Bugiardini
Keywords: Epidemiology, Europe, ISACS-CT, ischemic heart disease, MONICA
-
MAIN CLINICAL ARTICLE
The changing face of acute coronary syndromes
Steven E. Williams, Christopher N. Floyd, Michael Marber
Keywords: Acute coronary syndrome, angiography, angioplasty, myocardial infarction, non-ST-segment elevation, NSTEMI, percutaneous intervention, revascularization, STEMI, ST-segment elevation
-
METABOLIC IMAGING
Detecting acute coronary syndromes by magnetic resonance imaging
Afshin Farzaneh-Farab, Raymond Y. Kwongc
Keywords: Acute coronary syndrome, chest pain, magnetic resonance imaging, myocardial infarction, unstable angina
-
NEW THERAPEUTIC APPROACHES
Stable angina and female gender
Alda Huqi, Paola Capozza, Mario Marzilli
Keywords: Coronary artery disease, gender differences, ischemic heart disease
-
FOCUS ON VASTAREL® MR
Clinical benefits of trimetazidine (Vastarel® MR) in the changing scenario of ischemic heart disease
Elena Louette
Keywords: Cardiac energy metabolism, cardioprotection, diabetes, IHD, LV dysfunction, trimetazidine MR
-
CASE REPORT
Coronary microcirculation in effort ischemia: the roar of the rabbit
Paola Capozza, Enrico Orsini
Keywords: Coronary angiography, coronary slow flow, myocardial ischemia
-
REFRESHER CORNER
Lessons from EUROASPIRE I, II, and III surveys
Kornelia Kotseva
Keywords: Cardiovascular disease (CVD), coronary heart disease (CHD), EUROASPIRE, lifestyle and risk-factor management
-
HOT TOPICS
Interventional therapy for resistant hypertension: new hopes and old concerns!
Alda Huqi -
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Dilated cardiomyopathy
G. Jackson -
BASIC ARTICLE
Myocardial energy metabolism in dilated cardiomyopathy
W. C. Stanley
Keywords: fatty acids, glucose, heart failure, mitochondria
-
MAIN CLINICAL ARTICLE
Drugs and/or devices in dilated cardiomyopathy
H. P. Schultheiss, U. Kühl
Keywords: Anti-viral or immunomodulatory treatment, autoimmunity, dilated cardiomyopathy,heart failure therapy, ICD, immunosuppression, myocarditis
-
METABOLIC IMAGING
Metabolic imaging in dilated cardiomyopathy
S. Neubauer
Keywords: Dilated cardiomyopathy, energetics, magnetic resonance spectroscopy, metabolism, steatosis
-
NEW THERAPEUTIC APPROACHES
Metabolic modulation in dilated cardiomyopathy
H. Tuunanen, J. Knuuti
Keywords: etomoxir, Heart failure, metabolism, perhexiline, trimetazidine
-
FOCUS ON VASTAREL MR
The clinical benefits provided by trimetazidine in left ventricular dysfunction patients
G Marazzi, G. Caminiti, M. Voterrani
Keywords: Chronic heart failure, left ventricular function, metabolic therapy, trimetazidine
-
CASE REPORT
Response to cardiac resynchronization therapy resulting from an upgrade to dual-site left ventricular pacing
M. R. Ginks, S. G. Duckett, G. S. Carr-White, C. A. Rinaldi
Keywords: Cardiac resynchronization therapy, multi-site pacing, non-responder
-
REFRESHER CORNER
Cardiac amyloidosis
P. Schmidheiny, O. M. Hess
Keywords: Autologous stem cell transplantation, cardiac amyloidosis, cardiac arrhythmias, endomyocardial biopsy, restrictive cardiomyopathy
-
HOT TOPICS
Low diagnostic yield of coronary angiography or not catching up with heart disease pathophysiology?
A Huqi -
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Obesity and heart disease
Gary D. Lopaschuk -
BASIC ARTICLE
Free fatty acid oxidation in insulin resistance and obesity
E. Dale Abel -
MAIN CLINICAL ARTICLE
Obesity and mortality: summary of best evidence with explanations for the obesity paradox
Jennifer Logue, Naveed Sattar -
METABOLIC IMAGING
Functional imaging of brown adipose tissue
Kirsi A. Virtanena, Pirjo Nuutilaab -
NEW THERAPEUTIC APPROACHES
Stimulating brown fat: a potential future therapeutic approach for obesity and insulin resistance? -
FOCUS ON VASTAREL MR
Clinical benefits of trimetazidine in diabetic patients with coronary artery disease
Samir S. Wafa -
CASE REPORT
Comorbidity in the obese patient: the paroxysmal Pickwickian with pulmonary peculiarities and poor pump performance
Ian G. Webb, Michael Marber -
REFRESHER CORNER
Mitochondrial uncoupling proteins
Frédéric Bouillaud -
Hot topics
Risk factor modification and cardiovascular events: the gap is not yet bridged
Alda Huqi -
Hot topics
Abstracts and Commentaries: A new link between obesity and heart disease
Danielle Feuvray -
Glossary
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
What becomes of the brokenhearted?
Michael Marber -
BASIC ARTICLE
Basic mechanisms in apoptosis and heart failure
Roger Foo -
MAIN CLINICAL ARTICLE
Role of RAAS inhibition in preventing left ventricular remodeling in patients post myocardial infarction
Doralisa Morrone, Mario Marzilli -
METABOLIC IMAGING
Magnetic resonance imaging to assess ventricular remodeling
Otavio R. Coelho-Filhoa, Raymond Y. Kwonga, Michael Jerosch-Heroldb -
NEW THERAPEUTIC APPROACHES
Toll-like receptors: emerging therapeutic targets for heart failure
Stefan Frantz, Johann Bauersachs -
FOCUS ON VASTAREL MR
Clinical overview of trimetazidine (Vastarel MR) in patients with heart failure
Tiina Uuetoa -
CASE REPORT
Left ventricular remodeling after acute myocardial infarction with microvascular obstruction
Robin Nijveldt, Albert C. van Rossum -
REFRESHER CORNER
Ivabradine (Procoralan) alone or with ß-blockers in myocardial ischemia
Alain Berdeaux -
HOT TOPICS
Strategies to prevent left ventricular remodeling
Alda Huqi -
HOT TOPICS
Early diagnosis of myocardial infarction
Michael Marber -
GLOSSARY
Gary D. Lopaschuk
Download this article as a pdf file
Download all articles as pdf file
- EDITORIAL
Diabetes and cardiovascular disease
Gary D. Lopaschuk -
BASIC ARTICLE
Non ischemic heart failure in diabetes mellitus: still incompletely understood
Romain Harmancey, Heinrich Taegtmeyer -
MAIN CLINICAL ARTICLE
Clinical manifestations of diabetic cardiomyopathy
Sihem Boudina -
METABOLIC IMAGING
Nuclear magnetic resonance for the study of cardiac metabolism in diabetes
Giancarlo Todiere, Mario Marzilli -
NEW THERAPEUTIC APPROACHES
Cardiac considerations in the treatment of the metabolic syndrome
David S.H. Bell -
FOCUS ON VASTAREL MR
Clinical benefits of trimetazidine in patients with coronary artery disease and diabetes mellitus
Luis Rodríguez Padial -
CASE REPORT
Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis
Maurizio Galderisi, Rosa Raia -
EDITORIAL COMMENT
Editorial comment to the article “Reduction of coronary flow reserve in a patient with type 2 diabetes mellitus without epicardial coronary stenosis” by Maurizio Galderisi and Rosa Raia
Mario Marzilli -
REFRESHER CORNER
Energy metabolism in the heart of the diabetic patient
Danielle Feuvray -
FEATURED RESEARCH
Abstracts and Commentaries
Jagdip S. Jaswal, Gary D. Lopaschuk -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Circadian rhythms and cardiovascular disease
Danielle Feuvray -
BASIC ARTICLE
Diurnal variations in myocardial metabolism
Ju-Yun Tsai, Martin E. Young -
MAIN CLINICAL ARTICLE
Disruption of normal circadian rhythms and cardiovascular events
Alberto Dominguez-Rodrigueza, Pedro Abreu-Gonzalezb, Juan Carlos Kaskic -
METABOLIC IMAGING
Metabolic imaging with cardiac magnetic resonance spectroscopy
Stefan Neubauer -
NEW THERAPEUTIC APPROACHES
Rev-erba: a potential target for the treatment of circadian disorders
Hélène Duezabcd, Bart Staelsabcd -
FOCUS ON VASTAREL MR
Beneficial effects of Vastarel MR in protecting patients with stable coronary artery disease against early morning ischemic burden
Stephane Coquempot -
CASE REPORT
Jet lag
Graham Jackson -
REFRESHER CORNER
Melatonin and cardiac pathophysiology
Russel J. Reiter, Dun X. Tan -
FEATURED RESEARCH
Abstracts and Commentaries
Mario Marzilli -
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- TO OUR READERS
Change of Editor-in-Chief of Heart and Metabolism -
EDITORIAL
Biomarkers: past, present and future
Graham Jackson -
BASIC ARTICLE
The biological basis of troponin in heart disease: possible uses for troponin fragmentology
Vlad C. Vasile, Allan S. Jaffe -
MAIN CLINICAL ARTICLE
The role of biomarkers in clinical practice
Anthony S. Wierzbickia, Adie Viljoenb -
METABOLIC IMAGING
Troponin compared with late enhancement in the assessment of myocardial injury
Evangelos Giannitsis, Hugo A. Katus -
NEW THERAPEUTIC APPROACHES
Trends in genomic biomarkers
Bruce McManus -
FOCUS ON VASTAREL MR
Effects of Vastarel MR on brain natriuretic peptide and cardiac troponin concentrations
Pericle Di Napoli -
CASE REPORT
Serial determination of troponin concentrations in the diagnosis of acute myocardial infarction
Vlad C. Vasile, Lori A. Blauwet, Allan S. Jaffe -
REFRESHER CORNER
Temporal profile of protein release in myocardial infarction
Piero Montorsi, Marco Villa, Maria Antonietta Dessanai -
FEATURED RESEARCH
Abstracts and Commentaries
Mario Marzilli -
GLOSSARY
Gary D. Lopaschuk
Download all articles as pdf file
- EDITORIAL
Chronic ischemic heart disease
Mario Marzilli -
BASIC ARTICLE
Genomics, transcriptomics, and proteomics of the ischemic heart
Marcus C. Schauba, Eliana Lucchinettib, Michael Zauggb -
MAIN CLINICAL ARTICLE
Identifying patients at risk of progressive left ventricular dysfunction
Florence Pinet -
METABOLIC IMAGING
Magnetic resonance imaging and positron emission tomography as predictors of heart failure
Christoph Klein -
NEW THERAPEUTIC APPROACHES
Targeting oxidative stress in heart failure
Leong L. Ng -
FOCUS ON VASTAREL MR
Beneficial long-term effects of Vastarel MR in patients with stable coronary artery disease developing left ventricular dysfunction
Hamayak S. Sisakian -
CASE REPORT
Changing ischemic symptoms despite stable coronary anatomy
Mario Marzilli, Alda Huqi -
REFRESHER CORNER
Hibernation or repetitive stunning – does it matter?
Gerd Heuscha, Rainer Schulzb -
The clinical perspective
I. Rahman, R.S. Bonser -
FEATURED RESEARCH
Abstracts and Commentaries
Danielle Feuvray -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Taking genes to heart
Michael S. Marber -
BASIC ARTICLE
Genetics of cardiomyopathy and channelopathy
Connie R. Bezzina -
MAIN CLINICAL ARTICLE
What the practicing cardiologist needs to know about genetics and heart disease
Rahul C. Deo, Calum A. MacRae -
METABOLIC IMAGING
Imaging of myocardial receptors: applications in the evaluation of cardiac disease
Ornella Rimoldiabc, Paolo G. Camiciab -
NEW THERAPEUTIC APPROACHES
Gene therapy for cardiovascular manifestations of lysosomal storage diseases
Meg M. Sleepera, Mark E. Haskinsb, Katherine P. Ponderc -
FOCUS ON VASTAREL MR
Anti-ischemic cardioprotection with trimetazidine
Pericle Di Napoli -
CASE REPORT
Long-QT syndrome in a family with a KCNH2 mutation
Cliona Murphy, Jas Gill -
REFRESHER CORNER
How do mutations cause disease?
Jean-Jacques Mercadier -
FEATURED RESEARCH
Abstracts and commentaries
Mario Marzilli -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Coronary microvascular disease
Mario Marzilli -
BASIC ARTICLE
Microvascular control of myocardial perfusion
Helmut Habazettl, Axel R. Pries -
MAIN CLINICAL ARTICLE
Prognostic significance of microvascular dysfunction
Michael Weis -
METABOLIC IMAGING
Non invasive assessment of coronary microvascular dysfunction
Frans Visser -
NEW THERAPEUTIC APPROACHES
Improving perfusion at reperfusion
Mario Marzilli -
FOCUS ON VASTAREL MR
Reperfusion injury: reduction by Vastarel MR
Laurent Bonello, Franck Paganelli -
CASE REPORT
Microvascular obstruction after primary angioplasty: beyond the epicardial artery
Tim Lockie, Sven Plein, Simon Redwood -
REFRESHER CORNER
Cardiac syndrome X: pathogenesis and management
Juan Carlos Kaski, Kamran Iqbal -
FEATURED RESEARCH
Abstracts and commentaries
Mario Marzilli -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Measuring cardiac efficiency: is it clinically useful?
Frans Visser -
BASIC ARTICLE
Molecular basis of cardiac efficiency
Heiko Bugger, E. Dale Abel -
MAIN CLINICAL ARTICLE
Assessment and clinical applications of myocardial efficiency
Olakunle Akinboboye -
METABOLIC IMAGING
Myocardial efficiency in heart failure: non invasive imaging
Paul Knaapen, Tjeerd Germans -
NEW THERAPEUTIC APPROACHES
Improvement of cardiac efficiency in heart failure by cardiac resynchronization therapy
Matthew Ginks, C. Aldo Rinaldi -
FOCUS ON VASTAREL MR
Benefits of the metabolic approach in cardiac rehabilitation
Romualdo Belardinelli -
CASE REPORT
Improvement of myocardial efficiency in a patient with hypertrophic obstructive cardiomyopathy after alcohol septal ablation
Tjeerd Germans12*, Paul Knaapen1, Albert C. van Rossum12 -
REFRESHER CORNER
Invasive assessment of cardiac efficiency
Paul Steendijk, Ellen A. ten Brinke -
FEATURED RESEARCH
Abstracts and commentaries
Danielle Feuvray -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Stable angina – taking time
Graham Jackson -
BASIC ARTICLE
Optimizing cardiac energy substrate metabolism: a novel therapeutic intervention for ischemic heart disease
Jagdip S. Jaswal, Virgilio J.J. Cadete, Gary D. Lopaschuk -
MAIN CLINICAL ARTICLE
Stable angina: a balanced approach
Jon-David Schwalm, Koon K. Teo -
METABOLIC IMAGING
Magnetic resonance perfusion imaging for detection of ischemic heart disease
Eike Nagel -
NEW THERAPEUTIC APPROACHES
Coronary microcirculation: the new frontier in coronary artery disease
Mario Marzilli -
FOCUS ON VASTAREL MR
Efficacy of Vastarel MR on silent and symptomatic myocardial ischemia
Giuseppe Caminiti, Giuseppe Marazzi, Giuseppe Rosano -
CASE REPORT
Trimetazidine in the management of ischemic heart disease in a patient with diabetes mellitus and recurrent angina
Mario Marzilli -
REFRESHER CORNER
The place of exercise in the patient with chronic stable angina
Anil Nigam, Jean-Claude Tardif -
FEATURED RESEARCH
Abstracts and commentaries
Danielle Feuvray -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Go with the flow
Michael Marber -
BASIC ARTICLE
Consequences of reperfusion
Thorsten Reffelmann and Robert A. Kloner
Keywords: Ischemic preconditioning, myocardial salvage, no reflow, reperfusion, stunning
-
MAIN CLINICAL ARTICLE
Measuring reperfusion in the catheter laboratory
Ian Webb and Simon Redwood
Keywords: Microvascular dysfunction, primary angioplasty, reperfusion
-
METABOLIC IMAGING
Scoring reperfusion by contrast-enhanced magnetic resonance imaging
Giuseppe Tarantini and Sabino Iliceto
Keywords: Acute myocardial infarction, magnetic resonance imaging, primary angioplasty
-
NEW THERAPEUTIC APPROACHES
Postconditioning the human heart
Hélène Thibault, Denis Angoulvant, Cyrille Bergerot and Michel Ovize
Keywords: Ischemia, myocardial infarction, postconditioning, reperfusion
-
FOCUS ON TRIMETAZIDINE (VASTAREL MR)
Clinical benefi ts of a metabolic approach in the treatment of ischemic heart disease: focus on Vastarel MR
Mario Marzilli
Keywords: Angina, cardiac energy metabolism, ischemic heart disease, trimetazidine
-
CASE REPORT
Primary angioplasty: worth the trouble?
Mrinal Saha
Keywords: Acute myocardial infarction, bifurcation disease, clopidrogrel, kissing balloons, primary angioplasty
-
REFRESHER CORNER
The paradoxes of reperfusion in the ischemic heart
Naranjan S. Dhalla and Todd A. Duhamel
Keywords: Calcium-overload, cardiac dysfunction, ischemic myocardium, oxidative stress, reperfusion injury, subcellular remodeling
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Improving prognosis in ischemic heart disease: time to maximize benefit
Graham Jackson -
BASIC ARTICLE
The atherosclerotic plaque was not built in a day: the dynamic nature of plaque progression and instability
Martin R. Bennett
Keywords: Vascular smooth muscle cells, apoptosis, atherosclerosis, vascular, inflammation
-
MAIN CLINICAL ARTICLE
Pharmacologic prevention of coronary plaque rupture – the major cause of acute coronary syndromes
Petri T. Kovanen and Markku O. Pentikäinen
Keywords: Coronary artery disease, plaque rupture, pharmacotherapy
-
METABOLIC IMAGING
Metabolic imaging: the role of imaging in risk evaluation of ischemic heart disease
Mark T. Harbinson
Keywords: Ischemic heart disease, metabolic tracers, myocardial perfusion imaging, nuclear cardiology, prognosis
-
NEW THERAPEUTIC APPROACHES
Beyond pharmacology in heart attacks: coronary stents and stem cells
Cheuk-Kit Wong, Neal S. Kleiman and Harvey D. White
Keywords: Myocardial infarction, stem cells, stents
-
The Emperor has no clothes: reading between the lines of the COURAGE report
Mario Marzilli
Keywords: Angina, coronary artery disease, ischemic syndromes, percutaneous coronary intervention, percutaneous transluminal coronary angioplasty
-
FOCUS ON VASTAREL MR
The metabolic approach to improving prognosis in ischemic heart disease
Pericle Di Napoli
Keywords: Trimetazidine, heart failure, ischemic heart disease, prognosis
-
CASE REPORT
You are never too old
Cristiana Vitale
Keywords: Compliance, elderly, prognosis, trimetazidine
-
REFRESHER CORNER
Reducing the risks in diabetes
Giuseppe Rosano and Maria Cristina Ribaudo
Keywords: Cardiovascular events, diabetes mellitus, risk, cholesterol, hypertension, exercise
-
FEATURED RESEARCH
Abstracts and Commentaries
Gary Lopaschuk -
GLOSSARY
Gary D. Lopaschuk
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- EDITORIAL
Cardiac toxicity
Danielle Feuvray -
BASIC ARTICLE
Molecular basis of anthracycline-induced cardiotoxicity
Richard S. Vander Heide and Thomas J. L’Ecuyer
Keywords: Anthracycline, cardiotoxicity, cardiac muscle, oxidative stress, apoptosis, mechanism
-
MAIN CLINICAL ARTICLE
Mechanisms, manifestations, and management of digoxin toxicity
Lionel G. Lelièvre and Philippe Lechat
Keywords: Arrhythmias, digoxin, cardiotoxicity, human Naþ/Kþ-ATPase isoforms, ventricular tachycardia
-
METABOLIC IMAGING
Myocardial perfusion imaging and cardiac events in asymptomatic patients with diabetes
Denis Mariano-Goulart
Keywords: Diabetes mellitus, occult coronary artery disease, myocardial perfusion imaging, scintigraphy, screening
-
NEW THERAPEUTIC APPROACHES
Role of ATP-binding cassette transporters in drug distribution to the heart and protection from toxic compounds
Lucie Couture, John. A. Nash and Jacques Turgeon
Keywords: ABC transporters, cardiac drug distribution, cardiotoxicity, drug efflux, heart protection
-
FOCUS ON TRIMETAZIDINE (VASTAREL MR)
The importance of a metabolic approach to anti-ischemic protection
Graham Jackson
Keywords: Ischemia, ischemic burden, metabolic agents, trimetazidine
-
CASE REPORT
Trimetazidine and left ventricular dysfunction: patients must play their part also
Graham Jackson
Keywords: Alcohol excess, pre-diabetes, left ventricular dysfunction, lifestyle, trimetazidine
-
REFRESHER CORNER
Preventing the cardiotoxic effects of anthracyclines: from basic concepts to clinical data
Catherine Vergely, Stéphanie Delemasure, Yves Cottin and Luc Rochette
Keywords: Anthracyclines, cardiotoxicity, congestive heart failure, reactive oxygen species, ACE inhibitors
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Picture my heart!
Michael Marber -
BASIC ARTICLE
Coronary computed tomographic angiography: current and future uses
Birgit Kantor, Ronald S. Kuzo and Thomas C. Gerber
Keywords: Angiography, computed tomography, coronary artery disease, diagnosis
-
MAIN CLINICAL ARTICLE
Perspectives of new imaging techniques for patients with known or suspected coronary artery disease
Joanne D. Schuijf and Jeroen J. Bax
Keywords: Non invasive imaging, coronary artery disease
-
METABOLIC IMAGING
The future of positron emission tomography/computed tomography imaging of the heart
Philipp A. Kaufmann -
NEW THERAPEUTIC APPROACHES
Cardiac interventions guided by magnetic resonance imaging
Titus Kuehne
Keywords: Magnetic resonance imaging, intervention, congenital heart disease
-
FOCUS ON VASTAREL MR
Effi cacy of the metabolic approach in ischemic heart diseases. Non invasive assessment of myocardial perfusion, metabolism, and left ventricular function
Romualdo Belardinelli
Keywords: Metabolic modulation, chronic myocardial ischemia, trimetazidine, dobutamine stress echocardiography, SPECT imaging
-
CASE REPORT
Multislice computed tomography coronary angiography before percutaneous recanalization of chronic total occlusions
N. R. Mollet, N. Van Pelt, G. Sianos, W.B. Meijboom, F. Cademartiri and P.J. de Feyter
Keywords: Chronic total occlusion, coronary artery, multislice computed tomography, percutaneous revascularization
-
REFRESHER CORNER
Obtaining cardiac images from positron emission tomography, computed tomography, and magnetic resonance imaging: physical principles
Ronald Boellaard
Keywords: Physical principles, positron emission tomography, computed tomography, magnetic resonance imaging, cardiology, structural, functional, molecular, imaging
-
FEATURED RESEARCH
Abstracts and commentaries
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- EDITORIAL
Arrhythmia and metabolism
Danielle Feuvray -
BASIC ARTICLE
Metabolic signals of arrhythmia
Jason R.B.Dyck and Peter E. Light
Keywords: Arrhythmia, cardiac energy metabolism, ion channels, AMPK, PRKAG2
-
MAIN CLINICAL ARTICLE
Metabolic gene defects and risk of arrhythmia
Patrick T. Ellinor, David J. Milan and Calum A. MacRae
Keywords: Glycogen, fatty acid, mitochondrial, atrial fibrillation, ventricular tachycardia
-
METABOLIC IMAGING
Imaging and arrhythmia
Reza Razavi
Keywords: Arrhythmia, echocardiography, computed tomography, magnetic resonance imaging
-
NEW THERAPEUTIC APPROACHES
New therapeutic approaches in atrial fi brillation
Bas A. Schoonderwoerd and Isabelle C. Van Gelder
Keywords: Atrial fibrillation, antiarrhythmic drugs, anticoagulation, radiofrequency ablation, treatment
-
FOCUS ON VASTAREL MR
Modulation of metabolic changes in patients with heart failure by selective inhibition of 3-ketoacyl coenzyme A thiolase
Gabriele Fragasso, Altin Palloshi, Amarild Cuko and Roberto Spoladore
Keywords: Trimetazidine, heart failure, left ventricular function, glucose metabolism, free fatty acids
-
CASE REPORT
Anderson-Fabry disease: an important differential diagnosis in patients with unexplained left ventricular hypertrophy
Perry Elliott
Keywords: Anderson–Fabry disease, left ventricular hypertrophy, women
-
REFRESHER CORNER
Cellular changes in atrial fi brillation
Jolanda van der Velden, Nadiya A. Narolska and Ger J.M. Stienen
Keywords: Atrial fibrillation, contractility, cardiomyocyte function, contractile proteins
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Metabolic profi le in heart disease
Mario Marzilli -
BASIC ARTICLE
Understanding the metabolic phenotype of heart disease
Rong Tian
Keywords: energetics, heart failure, transgenic mice, fatty acid oxidation, glucose metabolism, metabolic therapy
-
MAIN CLINICAL ARTICLE
Clinical implications of energetic problems in cardiovascular disease
John R. Ussher and Gary D. Lopaschuk
Keywords: Fatty acid oxidation, trimetazidine, glucose oxidation, energy metabolism
-
METABOLIC IMAGING
Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy
Michiel ten Hove and Stefan Neubauer
Keywords: 31P-Magnetic resonance spectroscopy, 1H-magnetic resonance spectroscopy, 13C-magnetic resonance spectroscopy, cardiac metabolism
-
NEW THERAPEUTIC APPROACHES
Metabolic profiling in heart disease
David J. Grainger
Keywords: Metabonomics, atherosclerosis, myocardial infarction, pronostics
-
FOCUS ON VASTAREL MR
Trimetazidine and the metabolic profi le of ischemia
Graham Jackson
Keywords: Heart disease, left ventricular function, myocardial metabolism, prognosis, trimetazidine
-
CASE REPORT
Altered AMP-activated protein kinase activity and pathologic cardiac disease
Michael H. Gollob, Martin S. Green and John P. Veinot
Keywords: AMP-activated protein kinase (or AMPK), Wolff–Parkinson–White, arrhythmia, glycogen storage disease, hypertrophy, genetics
-
REFRESHER CORNER
Regulation of gene expression by polyunsaturated fatty acids
Harini Sampath and James M. Ntambi
Keywords: Polyunsaturated fatty acids, SREBP1c, PPAR, LXR
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Persistent angina: the good, the bad, and the ugly
Frans C. Visser -
BASIC ARTICLE
Oxidative stress and ischemia
Joël de Leiris, Andry Rakotovao and François Boucher
Keywords: Oxidative stress, free radicals, myocardial ischemia, reperfusion, cellular injury
-
MAIN CLINICAL ARTICLE
Persistent angina
Mario Marzilli, Marta Focardi, Silvia Affi nito, Eugenia Capati and Rossella Urselli
Keywords: Persistent angina, percutaneous transluminal coronary angioplasty, coronary stenosis, randomised intervention treatment of angina trial, arterial revascularization therapy study
-
IMAGING
Cardiac imaging for the detection of ischemia after percutaneous coronary intervention
Kenneth N. Giedd
Keywords: Computed tomography angiography, myocardial perfusion imaging, percutaneous coronary intervention
-
NEW THERAPEUTIC APPROACHES
Exciting developments in stable angina – the rise of the f-channels
Adrian J. B. Brady
Keywords: Angina, b-blockers, heart rate, cardiac ion channels, f-channels, If current, ivabradine
-
FOCUS ON VASTAREL MR
From recurrent ischemia to ischemic heart failure: new data on trimetazidine
Jaroslaw D. Kasprzak
Keywords: Ischemic cardiomyopathy, heart failure, recurrent ischemia, trimetazidine
-
CASE REPORT
Persistent angina after myocardial revascularization: a case report
Marta Focardi, Eugenia Capati, Silvia Affi nito, Rossella Urselli and Mario Marzilli
Keywords: Persistent angina, complete myocardial revascularization, microvascular angina, stable angina, stress test ischemia
-
REFRESHER CORNER
Warm up angina
Rainer Zbinden and Michael S. Marber
Keywords: Angina, ischemic preconditioning, myocardial collaterals
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Metabolic syndrome and its management
Gary Lopaschuk -
BASIC ARTICLE
Lipotoxicity in cardiac and skeletal muscle
Jennifer L. Peura and Jean E. Schaffer
Keywords: Lipotoxicity, cardiomyopathy, myopathy, fatty acids, triglycerides
-
MAIN CLINICAL ARTICLE
The metabolic syndrome
Bernhard O. Boehm and Stephan Schiekofer
Keywords: Diabetes, hyperglycemia, dyslipidemia, pleiotropic effects, lifestyle modification, metabolic syndrome
-
METABOLIC IMAGING
Metabolic imaging in the metabolic syndrome
Linda Peterson
Keywords: Metabolic syndrome, metabolism, positron emission tomography, heart, magnetic resonance spectroscopy
-
NEW THERAPEUTIC APPROACHES
Metabolic syndrome: pharmacological treatment
Pieter A. van Zwieten and Frans Visser
Keywords: Metabolic syndrome, insulin resistance, antihypertensive drugs, diabetes mellitus (type 2), obesity, hyperlipidemia
-
FOCUS ON VASTAREL MR
Effect of selective 3-ketoacyl coenzyme A thiolase inhibition on glucose metabolism in cardiac patients
Gabriele Fragasso et al.
Keywords: Trimetazidine, diabetes, glucose metabolism, left ventricular function, endothelial function, 3-ketoacyl coenzyme A thiolase inhibition
-
CASE REPORT
Hypercalcemia and the cardiovascular system
V.J. Karthikeyan et al.
Keywords: Hypercalcemia, hyperparathyroidism, hypertension, heart failure, complete heart block, renal failure
-
REFRESHER CORNER
What is insulin resistance?
Gurushankar Govindarajan et al.
Keywords: Hypertension, polycystic ovary disease, cardiometabolic syndrome, diabetes mellitus, cardiovascular disease, renal disease
-
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Bypass surgery for coronary artery disease: a vanishing treatment?
Frans Visser -
BASIC ARTICLE
Mechanism of cardiac damage associated with cardiac surgery
David J. Chambers -
MAIN CLINICAL ARTICLE
Managing contractile dysfunction after cardiac surgery
Armand R. Girbes and A. B. Johan Groeneveld -
METABOLIC IMAGING
Value of perioperative transesophageal echocardiography
Otto Kamp -
NEW THERAPEUTIC APPROACHES
Metabolic interventions during cardiac surgery: focus on glucose–insulin–potassium
Harry B. van Wezel -
FOCUS ON VASTAREL MR
Protective effects of trimetazidine before and after coronary artery bypass surgery
Álvaro D.B. Bordalo -
CASE REPORT
Hibernating myocardium and coronary artery bypass surgery
Ian Hunt and Tunde Ogunyiluka -
REFRESHER CORNER
Risk associated with cardiac surgery
Christopher Blauth -
FEATURED RESEARCH
Abstracts and commentaries
Download all articles as pdf file
- EDITORIAL
Graham Jackson -
BASIC ARTICLE
Erectile dysfunction as an early indicator of cardiovascular and metabolic disease
Kevin L. Billups -
MAIN CLINICAL ARTICLE
Managing sexual dysfunction in the cardiac patient
Adolph M. Hutter Jr -
NEW THERAPEUTIC APPROACHES
Safety and efficacy of the medical treatment of erectile dysfunction
Graham Jackson -
FOCUS ON VASTAREL MR
Efficacy and safety of trimetazidine and phosphodiesterase type-5 inhibitors
Graham Jackson -
CASE REPORT
Erectile dysfunction as a marker of silent ischemia
Michael Kirby -
REFRESHER CORNER
The hemodynamics of sex
Ian Eardley -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Metabolic approach in heart failure
Graham Jackson -
BASIC ARTICLE
Metabolic approach in heart failure: the rationale for metabolic interventions
Gary D. Lopaschuk, William A. Stanley, Catharine C. Lopaschuk -
MAIN CLINICAL ARTICLE
The place of metabolic treatment
Hanna Szwed -
METABOLIC IMAGING
Glucose–insulin–potassium infusion enhances myocardial wall motion in patients with chronic ischemic heart failure
Lucas J. Klein, Linda (C.) M.C. van Campen, Thomas H. Marwick -
NEW THERAPEUTIC APPROACHES
Evidence of efficacy of metabolic agents
Mario Marzilli, Silvia Affinito -
FOCUS ON VASTAREL MR
Vastarel MR: an innovative metabolic approach to ischemic heart failure
Elena Louette -
CASE REPORT
An elderly lady with angina and heart failure—successful response to trimetazidine
Graham Jackson -
REFRESHER CORNER
Metabolic link between ischemia and cardiac dysfunction
William C. Stanley -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
Gary Lopaschuk
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- EDITORIAL
Cardiovascular effects of exercise
M. Marzilli -
BASIC ARTICLE
Adaptive and maladaptive cardiac hypertrophy
M. F. Allard -
MAIN CLINICAL ARTICLE
Risks and benefits of exercise in cardiac disease
N. Smart, T. H. Marwick -
METABOLIC IMAGING
Imaging: hypertrophic cardiomyopathy and athlete’s heart
I. Paetsch, E. Nagel -
NEW THERAPEUTIC APPROACHES
Constructing an exercise program
A. A. McLeod -
FOCUS ON VASTAREL MR
New therapeutic approach in chronic heart failure: metabolic intervention with trimetazidine
H. S. Sisakyan -
CASE REPORT
Sustained benefit of trimetazidine adjunct to standard treatment in severe heart failure
M. Marzilli -
REFRESHER CORNER
Cardiac adaptation to exercise
H. Kuipers -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
G. Lopaschuk
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- EDITORIAL
Heart failure in diabetes
M. Marber -
BASIC ARTICLE
Metabolic derangements in insulin resistance
D. Feuvray -
MAIN CLINICAL ARTICLE
Management of chronic heart failure in patients with type 2 diabetes: the importance of an integrated approach
V. A. Ezzat, M. T. Kearney -
METABOLIC IMAGING
Metabolic imaging and diabetes
J. Knuuti -
NEW THERAPEUTIC APPROACHES
Novel approaches in the treatment of diabetes mellitus diabetic cardiomyopathy
R. Belardinelli -
FOCUS ON VASTAREL MR
Ischemic heart disease and diabetes: rationale for a metabolic approach, and clinical evidence
P. Meurin, T. He´nane -
CASE REPORT
Diabetes and heart failure
S. Wheatcroft -
REFRESHER CORNER
Peroxisome proliferator-activated receptors and the cardiovascular system
L. A. Nikolaidis, T. B. Levine -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
G. Lopaschuk
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- EDITORIAL
What’s new in angina pectoris?
F. C. Visser -
BASIC ARTICLE
Molecular mechanisms of cardiac ischemic pain
F. Crea -
MAIN CLINICAL ARTICLE
Risk stratification in chronic stable angina
M. Marzilli -
METABOLIC IMAGING
Imaging the coronary vasculature using multislice computed tomography
N. R. Mollet et al -
NEW THERAPEUTIC APPROACHES
New developments in the drug treatment of stable angina pectoris
P. A. van Zwieten, F. C. Visser -
FOCUS ON VASTAREL MR
Vastarel MR: effective and safe for coronary patients treated with a phosphodiesterase type 5 inhibitor
G. Rosano -
CASE REPORT
Neurogenic induced myocardial dysfunction
I. A. C. van der Bilt, F. C. Visser -
REFRESHER CORNER
Assessment of collateral circulation
Gerald S. Werner -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
G. Lopaschuk
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- EDITORIAL
Metabolic interventions for acute coronary syndromes?
F. C. Visser -
BASIC ARTICLE
Alterations in energy metabolism in acute coronary syndromes
A. Noga, J. R. B Dyck, G. Lopaschuk -
MAIN CLINICAL ARTICLE
Risk stratification and outcome in non-ST-segment elevation in acute coronary syndromes R. Malhotra and M. S. Sabatine -
METABOLIC IMAGING
Glucose and fatty acid changes in acute coronary syndromes
A-S. E. Hamby¨e, P. R. Franken -
NEW THERAPEUTIC APPROACHES
Guidelines and metabolic approach to acute coronary syndrome
F. R. Eberli -
FOCUS ON VASTAREL MR
Metabolic cardioprotection in patients undergoing revascularization
P. Meurin and T. He´nane -
CASE REPORT
Beneficial role of metabolic treatment in a patient with refractory angina after an
acute coronary syndrome
H. Szwed -
REFRESHER CORNER
Metabolic changes in ischemia and myocardial infarction
W. C. Stanley -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
G. Lopaschuk
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- EDITORIAL
Endothelial dysfunction
G. Jackson -
BASIC ARTICLE
Endothelial function and dysfunction
P. Vanhoutte -
MAIN CLINICAL ARTICLE
Clinical expression of endothelial dysfunction
W. Dunn, A. Lerman, V. Shah -
METABOLIC IMAGING
Imaging of coronary endothelial dysfunction by use of positron emission tomography
F. M. Bengel -
NEW THERAPEUTIC APPROACHES
Treatment options for endothelial dysfunction
S. von Haehling -
FOCUS ON VASTAREL MR
Evidence-based efficacy of Vastarel in patients with ischemic cardiomyopathy
H. C. Tan -
CASE REPORT
Imaging of endothelial dysfunction
P. Knaapen, W. G. van Dockum -
REFRESHER CORNER
Regulation of coronary perfusion
S. J. Fraser, D. E. Newby, N. G. Uren -
FEATURED RESEARCH
Abstracts and commentaries -
GLOSSARY
